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- W2107632694 abstract "Yeast is a widely used recombinant protein expression system. We expanded its utility by engineering the yeast Pichia pastoris to secrete human glycoproteins with fully complex terminally sialylated N-glycans. After the knockout of four genes to eliminate yeast-specific glycosylation, we introduced 14 heterologous genes, allowing us to replicate the sequential steps of human glycosylation. The reported cell lines produce complex glycoproteins with greater than 90% terminal sialylation. Finally, to demonstrate the utility of these yeast strains, functional recombinant erythropoietin was produced." @default.
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- W2107632694 date "2006-09-08" @default.
- W2107632694 modified "2023-10-17" @default.
- W2107632694 title "Humanization of Yeast to Produce Complex Terminally Sialylated Glycoproteins" @default.
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- W2107632694 doi "https://doi.org/10.1126/science.1130256" @default.
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