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- W2107648105 abstract "Calcium levels in spines play a significant role in determining the sign and magnitude of synaptic plasticity. Recent experiments using calcium sensitive dyes have allowed measurements of calcium transients in whole spines, however experimental resolution does not allow imaging of the spatial distribution of calcium within the spine [1,2,5]. Calcium can activate Calcineurin or bind to CaM and consequently activate CaMKII which is key mediator of synaptic plasticity. A main source of calcium influx into the spine is from the NMDA receptors. There are four different subtypes of obligatory NR2 subunits of NMDA receptors, NR2A/B/C/D. In the mature cortex the majority of the synaptic NMDA receptors are constituted by NR1/NR2A and in the immature cortex by NR1/NR2B. Experiments have shown that the subunit composition of NMDA receptors has an influence on the sign of synaptic plasticity, but different experiments resulted in different and possibly conflicting results [3,4]. NR2B has slower kinetics and higher affinity for Glutamate than that of NR2A. In addition NR2B receptors have a binding site for CaMKII." @default.
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- W2107648105 date "2007-07-01" @default.
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- W2107648105 title "Spatiotemporal dynamics of calcium and calmodulin at the spine" @default.
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- W2107648105 doi "https://doi.org/10.1186/1471-2202-8-s2-p92" @default.
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