FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107652148> ?p ?o ?g. }

• W2107652148 endingPage "2714" @default.
• W2107652148 startingPage "2707" @default.
• W2107652148 abstract "Objective— The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of macrophage cholesterol efflux and protects cells from excess intracellular cholesterol accumulation; however, the mechanism involved in posttranscriptional regulation of ABCA1 is poorly understood. We previously showed that microRNA-33 (miR-33) is 1 regulator. Here, we investigated the potential contribution of other microRNAs (miRNAs) to posttranscriptional regulation of ABCA1 and macrophage cholesterol efflux. Methods and Results— We performed a bioinformatic analysis for identifying miRNA target prediction sites in ABCA1 gene and an unbiased genome-wide screen to identify miRNAs modulated by cholesterol excess in mouse peritoneal macrophages. Quantitative real-time reverse transcription–polymerase chain reaction confirmed that miR-758 is repressed in cholesterol-loaded macrophages. Under physiological conditions, high dietary fat excess in mice repressed miR-758 both in peritoneal macrophages and, to a lesser extent, in the liver. In mouse and human cells in vitro, miR-758 repressed the expression of ABCA1, and conversely, the inhibition of this miRNA by using anti-miR-758 increased ABCA1 expression. In mouse cells, miR-758 reduced cellular cholesterol efflux to apolipoprotein A1 (apoA1), and anti-miR-758 increased it. miR-758 directly targets the 3′-untranslated region of Abca1 as assessed by 3′-untranslated region luciferase reporter assays. Interestingly, miR-758 is highly expressed in the brain, where it also targets several genes involved in neurological functions, including Slc38a1, Ntm, Epha7 , and Mytl1 . Conclusion— We identified miR-758 as a novel miRNA that posttranscriptionally controls ABCA1 levels in different cells and regulates macrophage cellular cholesterol efflux to apoA1, opening new avenues to increase apoA1 and raise high-density lipoprotein levels." @default.
• W2107652148 created "2016-06-24" @default.
• W2107652148 creator A5002528642 @default.
• W2107652148 creator A5027986135 @default.
• W2107652148 creator A5037055398 @default.
• W2107652148 creator A5048379477 @default.
• W2107652148 creator A5049834976 @default.
• W2107652148 creator A5055147698 @default.
• W2107652148 creator A5066158259 @default.
• W2107652148 creator A5087401568 @default.
• W2107652148 date "2011-11-01" @default.
• W2107652148 modified "2023-10-13" @default.
• W2107652148 title "MicroRNA-758 Regulates Cholesterol Efflux Through Posttranscriptional Repression of ATP-Binding Cassette Transporter A1" @default.
• W2107652148 cites W1860908381 @default.
• W2107652148 cites W1970761589 @default.
• W2107652148 cites W1973747307 @default.
• W2107652148 cites W1975141499 @default.
• W2107652148 cites W1981468132 @default.
• W2107652148 cites W1991166529 @default.
• W2107652148 cites W1996168740 @default.
• W2107652148 cites W2001777082 @default.
• W2107652148 cites W2007960303 @default.
• W2107652148 cites W2009616432 @default.
• W2107652148 cites W2013111251 @default.
• W2107652148 cites W2014946489 @default.
• W2107652148 cites W2025165872 @default.
• W2107652148 cites W2027231471 @default.
• W2107652148 cites W2028943130 @default.
• W2107652148 cites W2040641918 @default.
• W2107652148 cites W2042284982 @default.
• W2107652148 cites W2046797281 @default.
• W2107652148 cites W2052117565 @default.
• W2107652148 cites W2059357290 @default.
• W2107652148 cites W2075728036 @default.
• W2107652148 cites W2093296161 @default.
• W2107652148 cites W2093810123 @default.
• W2107652148 cites W2102901373 @default.
• W2107652148 cites W2124927590 @default.
• W2107652148 cites W2128751721 @default.
• W2107652148 cites W2139342290 @default.
• W2107652148 cites W2142310248 @default.
• W2107652148 cites W2154236306 @default.
• W2107652148 cites W2154694480 @default.
• W2107652148 cites W2154843786 @default.
• W2107652148 cites W2161693225 @default.
• W2107652148 cites W2162674813 @default.
• W2107652148 cites W2162877470 @default.
• W2107652148 cites W2163153721 @default.
• W2107652148 cites W4256317085 @default.
• W2107652148 doi "https://doi.org/10.1161/atvbaha.111.232066" @default.
• W2107652148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3298756" @default.
• W2107652148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21885853" @default.
• W2107652148 hasPublicationYear "2011" @default.
• W2107652148 type Work @default.
• W2107652148 sameAs 2107652148 @default.
• W2107652148 citedByCount "216" @default.
• W2107652148 countsByYear W21076521482012 @default.
• W2107652148 countsByYear W21076521482013 @default.
• W2107652148 countsByYear W21076521482014 @default.
• W2107652148 countsByYear W21076521482015 @default.
• W2107652148 countsByYear W21076521482016 @default.
• W2107652148 countsByYear W21076521482017 @default.
• W2107652148 countsByYear W21076521482018 @default.
• W2107652148 countsByYear W21076521482019 @default.
• W2107652148 countsByYear W21076521482020 @default.
• W2107652148 countsByYear W21076521482021 @default.
• W2107652148 countsByYear W21076521482022 @default.
• W2107652148 countsByYear W21076521482023 @default.
• W2107652148 crossrefType "journal-article" @default.
• W2107652148 hasAuthorship W2107652148A5002528642 @default.
• W2107652148 hasAuthorship W2107652148A5027986135 @default.
• W2107652148 hasAuthorship W2107652148A5037055398 @default.
• W2107652148 hasAuthorship W2107652148A5048379477 @default.
• W2107652148 hasAuthorship W2107652148A5049834976 @default.
• W2107652148 hasAuthorship W2107652148A5055147698 @default.
• W2107652148 hasAuthorship W2107652148A5066158259 @default.
• W2107652148 hasAuthorship W2107652148A5087401568 @default.
• W2107652148 hasBestOaLocation W21076521481 @default.
• W2107652148 hasConcept C104317684 @default.
• W2107652148 hasConcept C105580179 @default.
• W2107652148 hasConcept C119056186 @default.
• W2107652148 hasConcept C145059251 @default.
• W2107652148 hasConcept C149011108 @default.
• W2107652148 hasConcept C150194340 @default.
• W2107652148 hasConcept C153911025 @default.
• W2107652148 hasConcept C165864922 @default.
• W2107652148 hasConcept C186310378 @default.
• W2107652148 hasConcept C200082930 @default.
• W2107652148 hasConcept C2777704780 @default.
• W2107652148 hasConcept C2778163477 @default.
• W2107652148 hasConcept C54355233 @default.
• W2107652148 hasConcept C55493867 @default.
• W2107652148 hasConcept C6929976 @default.
• W2107652148 hasConcept C86803240 @default.
• W2107652148 hasConcept C89604277 @default.
• W2107652148 hasConcept C95444343 @default.
• W2107652148 hasConceptScore W2107652148C104317684 @default.
• W2107652148 hasConceptScore W2107652148C105580179 @default.

• next