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- W2107657692 abstract "The classic heat shock (stress) response (HSR) was originally attributed to protein denaturation. However, heat shock protein (Hsp) induction occurs in many circumstances where no protein denaturation is observed. Recently considerable evidence has been accumulated to the favor of the “Membrane Sensor Hypothesis” which predicts that the level of Hsps can be changed as a result of alterations to the plasma membrane. This is especially pertinent to mild heat shock, such as occurs in fever. In this condition the sensitivity of many transient receptor potential (TRP) channels is particularly notable. Small temperature stresses can modulate TRP gating significantly and this is influenced by lipids. In addition, stress hormones often modify plasma membrane structure and function and thus initiate a cascade of events, which may affect HSR. The major transactivator heat shock factor-1 integrates the signals originating from the plasma membrane and orchestrates the expression of individual heat shock genes. We describe how these observations can be tested at the molecular level, for example, with the use of membrane perturbers and through computational calculations. An important fact which now starts to be addressed is that membranes are not homogeneous nor do all cells react identically. Lipidomics and cell profiling are beginning to address the above two points. Finally, we observe that a deregulated HSR is found in a large number of important diseases where more detailed knowledge of the molecular mechanisms involved may offer timely opportunities for clinical interventions and new, innovative drug treatments. This article is part of a Special Issue entitled: Membrane Structure and Function: Relevance in the Cell's Physiology, Pathology and Therapy." @default.
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- W2107657692 date "2014-06-01" @default.
- W2107657692 modified "2023-10-07" @default.
- W2107657692 title "Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications" @default.
- W2107657692 cites W115356933 @default.
- W2107657692 cites W1484545872 @default.
- W2107657692 cites W1488329806 @default.
- W2107657692 cites W1508224413 @default.
- W2107657692 cites W1511198581 @default.
- W2107657692 cites W1531362395 @default.
- W2107657692 cites W1554180547 @default.
- W2107657692 cites W1557646389 @default.
- W2107657692 cites W1606095852 @default.
- W2107657692 cites W1614390781 @default.
- W2107657692 cites W1701505530 @default.
- W2107657692 cites W1825533445 @default.
- W2107657692 cites W1841940803 @default.
- W2107657692 cites W1892227647 @default.
- W2107657692 cites W1964117008 @default.
- W2107657692 cites W1964372860 @default.
- W2107657692 cites W1964538022 @default.
- W2107657692 cites W1965527012 @default.
- W2107657692 cites W1965792398 @default.
- W2107657692 cites W1966103529 @default.
- W2107657692 cites W1966236473 @default.
- W2107657692 cites W1966452335 @default.
- W2107657692 cites W1966560260 @default.
- W2107657692 cites W1966740493 @default.
- W2107657692 cites W1966986473 @default.
- W2107657692 cites W1967094356 @default.
- W2107657692 cites W1967230525 @default.
- W2107657692 cites W1967622387 @default.
- W2107657692 cites W1968046099 @default.
- W2107657692 cites W1968721371 @default.
- W2107657692 cites W1968835796 @default.
- W2107657692 cites W1969765070 @default.
- W2107657692 cites W1970762301 @default.
- W2107657692 cites W1971313680 @default.
- W2107657692 cites W1973376371 @default.
- W2107657692 cites W1973518711 @default.
- W2107657692 cites W1973616465 @default.
- W2107657692 cites W1973800195 @default.
- W2107657692 cites W1974899316 @default.
- W2107657692 cites W1975696535 @default.
- W2107657692 cites W1975782613 @default.
- W2107657692 cites W1976437851 @default.
- W2107657692 cites W1977107801 @default.
- W2107657692 cites W1977699070 @default.
- W2107657692 cites W1978182707 @default.
- W2107657692 cites W1978616237 @default.
- W2107657692 cites W1979013757 @default.
- W2107657692 cites W1981328110 @default.
- W2107657692 cites W1981367181 @default.
- W2107657692 cites W1981657572 @default.
- W2107657692 cites W1981678504 @default.
- W2107657692 cites W1981948991 @default.
- W2107657692 cites W1983194893 @default.
- W2107657692 cites W1983496542 @default.
- W2107657692 cites W1985309426 @default.
- W2107657692 cites W1985411684 @default.
- W2107657692 cites W1986015271 @default.
- W2107657692 cites W1986834353 @default.
- W2107657692 cites W1989207373 @default.
- W2107657692 cites W1989966995 @default.
- W2107657692 cites W1990569309 @default.
- W2107657692 cites W1990647376 @default.
- W2107657692 cites W1990769918 @default.
- W2107657692 cites W1991229275 @default.
- W2107657692 cites W1991276103 @default.
- W2107657692 cites W1992460272 @default.
- W2107657692 cites W1992572387 @default.
- W2107657692 cites W1993507619 @default.
- W2107657692 cites W1993643311 @default.
- W2107657692 cites W1993791556 @default.
- W2107657692 cites W1994367464 @default.