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- W2107658520 abstract "Transforming growth factor beta 1 (TGF-β1) and its closely related homologue, TGF-β2, rapidly induce growth factor gene expression by freshly isolated human peripheral blood monocytes. Within 3 h of exposure to TGF-β, mRNA species specific for interleukin-1 (IL-1β), tumor necrosis factor-α (TNF-α), platelet-derived growth factor (PDGF), and basic fibroblast growth factor (bFGF) were observed. By 14-18 h, cytokine bioactivity and protein were detected in the culture supernatants. Furthermore, not only TGF-β1, but also TGF-β2 mRNA are expressed constitutively in unstimulated monocytes. However, in response to exogenous TGF-β (βl or β2), only TGF-β1 gene expression is upregulated, and the expression of TGF-β2 mRNA is unchanged. This selective autoinduction of TGF-β1 appears to be controlled at both transcriptional and post-transcriptional levels. These paracrine and autocrine activities of TGF-β suggest potential mechanisms through which an inflammatory response can be initiated and amplified. In addition, the TGF-β enhancement of growth factor generation may promote fibrosis and angiogenesis relevant to physiological tissue repair as well as pathological fibrotic sequelae." @default.
- W2107658520 created "2016-06-24" @default.
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- W2107658520 date "1990-01-01" @default.
- W2107658520 modified "2023-09-27" @default.
- W2107658520 title "TGF-β Regulates Production of Growth Factors and TGF-β by Human Peripheral Blood Monocytes" @default.
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- W2107658520 doi "https://doi.org/10.3109/08977199009011007" @default.
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