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- W2107668840 abstract "Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the alpha7 subtype is highly expressed in the hippocampus and cortex and is thought to play important roles in a variety of cognitive processes. In this review, we describe the properties of a novel biaryl diamine alpha7 nAChR agonist, A-582941. A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS). In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation. A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit. A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function. The studies summarized in this review collectively provide preclinical validation that alpha7 nAChR agonism offers a mechanism with potential to improve cognitive deficits associated with various neurodegenerative and psychiatric disorders." @default.
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- W2107668840 date "2008-03-01" @default.
- W2107668840 modified "2023-10-18" @default.
- W2107668840 title "Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties" @default.
- W2107668840 cites W1234099513 @default.
- W2107668840 cites W1568560565 @default.
- W2107668840 cites W1571127945 @default.
- W2107668840 cites W1603203793 @default.
- W2107668840 cites W1900806927 @default.
- W2107668840 cites W1964016010 @default.
- W2107668840 cites W1964749017 @default.
- W2107668840 cites W1970671532 @default.
- W2107668840 cites W1971009901 @default.
- W2107668840 cites W1971513938 @default.
- W2107668840 cites W1974306203 @default.
- W2107668840 cites W1974560730 @default.
- W2107668840 cites W1975447960 @default.
- W2107668840 cites W1976692785 @default.
- W2107668840 cites W1978530682 @default.
- W2107668840 cites W1979478040 @default.
- W2107668840 cites W1980128229 @default.
- W2107668840 cites W1983379978 @default.
- W2107668840 cites W1984192824 @default.
- W2107668840 cites W1993337719 @default.
- W2107668840 cites W1994244053 @default.
- W2107668840 cites W1994751724 @default.
- W2107668840 cites W1996613015 @default.
- W2107668840 cites W2016729909 @default.
- W2107668840 cites W2017870121 @default.
- W2107668840 cites W2019990977 @default.
- W2107668840 cites W2020927120 @default.
- W2107668840 cites W2022440734 @default.
- W2107668840 cites W2024529818 @default.
- W2107668840 cites W2027238098 @default.
- W2107668840 cites W2029743369 @default.
- W2107668840 cites W2030526585 @default.
- W2107668840 cites W2033585547 @default.
- W2107668840 cites W2034082268 @default.
- W2107668840 cites W2035490871 @default.
- W2107668840 cites W2036740367 @default.
- W2107668840 cites W2037068227 @default.
- W2107668840 cites W2042537322 @default.
- W2107668840 cites W2045855926 @default.
- W2107668840 cites W2050524613 @default.
- W2107668840 cites W2051606745 @default.
- W2107668840 cites W2051669115 @default.
- W2107668840 cites W2052861568 @default.
- W2107668840 cites W2053266420 @default.
- W2107668840 cites W2053457282 @default.
- W2107668840 cites W2062689073 @default.
- W2107668840 cites W2068357891 @default.
- W2107668840 cites W2074617527 @default.
- W2107668840 cites W2074915076 @default.
- W2107668840 cites W2074953815 @default.
- W2107668840 cites W2076338351 @default.
- W2107668840 cites W2076749095 @default.
- W2107668840 cites W2081391428 @default.
- W2107668840 cites W2083540742 @default.