FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107675168> ?p ?o ?g. }

• W2107675168 endingPage "294" @default.
• W2107675168 startingPage "283" @default.
• W2107675168 abstract "Obliterative bronchiolitis (OB) develops insidiously in nearly half of all lung transplant recipients. Although typically preceded by a CD8(+) T cell-rich lymphocytic bronchitis, it remains unresponsive to conventional immunosuppression. Using an airflow permissive model to study the role of gases flowing over the transplanted airway, it is shown that prolonged inhalation of sublethal doses of carbon monoxide (CO), but not nitric oxide (NO), obliterate the appearance of the obstructive airway lesion. Induction of the enzyme responsible for the synthesis of CO, heme oxygenase (Hmox) 1, increased carboxyhemoglobin levels and suppressed lymphocytic bronchitis and airway luminal occlusion after transplantation. In contrast, zinc protoporphyrin IX, a competitive inhibitor of Hmox, increased airway luminal occlusion. Compared with wild-type allografts, expression of inducible NO synthase (iNOS), which promotes the influx of cytoeffector leukocytes and airway graft rejection, was strikingly reduced by either enhanced expression of Hmox-1 or exogenous CO. Hmox-1/CO decreased nuclear factor (NF)-kappaB binding activity to the iNOS promoter region and iNOS expression. Inhibition of soluble guanylate cyclase did not interfere with the ability of CO to suppress OB, implicating a cyclic guanosine 3',5'-monophosphate-independent mechanism through which CO suppresses NF-kappaB, iNOS transcription, and OB. Prolonged CO inhalation represents a new immunosuppresive strategy to prevent OB." @default.
• W2107675168 created "2016-06-24" @default.
• W2107675168 creator A5001283472 @default.
• W2107675168 creator A5001430907 @default.
• W2107675168 creator A5010942158 @default.
• W2107675168 creator A5038695535 @default.
• W2107675168 creator A5063512974 @default.
• W2107675168 date "2005-07-18" @default.
• W2107675168 modified "2023-10-16" @default.
• W2107675168 title "Reciprocal regulation of airway rejection by the inducible gas-forming enzymes heme oxygenase and nitric oxide synthase" @default.
• W2107675168 cites W1482570752 @default.
• W2107675168 cites W1483732515 @default.
• W2107675168 cites W1500284214 @default.
• W2107675168 cites W1540020157 @default.
• W2107675168 cites W1550443883 @default.
• W2107675168 cites W1591881963 @default.
• W2107675168 cites W1600690434 @default.
• W2107675168 cites W180714979 @default.
• W2107675168 cites W1967207824 @default.
• W2107675168 cites W1973081785 @default.
• W2107675168 cites W1979868072 @default.
• W2107675168 cites W1987952748 @default.
• W2107675168 cites W1997849875 @default.
• W2107675168 cites W2011496352 @default.
• W2107675168 cites W2020941408 @default.
• W2107675168 cites W2033914311 @default.
• W2107675168 cites W2039617287 @default.
• W2107675168 cites W2050971607 @default.
• W2107675168 cites W2057527796 @default.
• W2107675168 cites W2058230075 @default.
• W2107675168 cites W2067739721 @default.
• W2107675168 cites W2082249712 @default.
• W2107675168 cites W2088398511 @default.
• W2107675168 cites W2100280306 @default.
• W2107675168 cites W2122167506 @default.
• W2107675168 cites W2136699324 @default.
• W2107675168 cites W2137553082 @default.
• W2107675168 cites W2145287139 @default.
• W2107675168 cites W2145530136 @default.
• W2107675168 cites W2151556390 @default.
• W2107675168 cites W2166803343 @default.
• W2107675168 cites W2167187150 @default.
• W2107675168 cites W2168933371 @default.
• W2107675168 cites W2171232463 @default.
• W2107675168 cites W2323001878 @default.
• W2107675168 cites W2404839413 @default.
• W2107675168 cites W2412468390 @default.
• W2107675168 cites W4237438367 @default.
• W2107675168 cites W4246057271 @default.
• W2107675168 cites W4313309880 @default.
• W2107675168 doi "https://doi.org/10.1084/jem.20050377" @default.
• W2107675168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2213014" @default.
• W2107675168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16027238" @default.
• W2107675168 hasPublicationYear "2005" @default.
• W2107675168 type Work @default.
• W2107675168 sameAs 2107675168 @default.
• W2107675168 citedByCount "44" @default.
• W2107675168 countsByYear W21076751682012 @default.
• W2107675168 countsByYear W21076751682013 @default.
• W2107675168 countsByYear W21076751682014 @default.
• W2107675168 countsByYear W21076751682015 @default.
• W2107675168 countsByYear W21076751682016 @default.
• W2107675168 countsByYear W21076751682017 @default.
• W2107675168 countsByYear W21076751682018 @default.
• W2107675168 countsByYear W21076751682019 @default.
• W2107675168 countsByYear W21076751682021 @default.
• W2107675168 countsByYear W21076751682022 @default.
• W2107675168 countsByYear W21076751682023 @default.
• W2107675168 crossrefType "journal-article" @default.
• W2107675168 hasAuthorship W2107675168A5001283472 @default.
• W2107675168 hasAuthorship W2107675168A5001430907 @default.
• W2107675168 hasAuthorship W2107675168A5010942158 @default.
• W2107675168 hasAuthorship W2107675168A5038695535 @default.
• W2107675168 hasAuthorship W2107675168A5063512974 @default.
• W2107675168 hasBestOaLocation W21076751681 @default.
• W2107675168 hasConcept C126322002 @default.
• W2107675168 hasConcept C181199279 @default.
• W2107675168 hasConcept C185592680 @default.
• W2107675168 hasConcept C203014093 @default.
• W2107675168 hasConcept C2776217839 @default.
• W2107675168 hasConcept C2777622882 @default.
• W2107675168 hasConcept C2779219270 @default.
• W2107675168 hasConcept C519581460 @default.
• W2107675168 hasConcept C55493867 @default.
• W2107675168 hasConcept C71924100 @default.
• W2107675168 hasConcept C98274493 @default.
• W2107675168 hasConceptScore W2107675168C126322002 @default.
• W2107675168 hasConceptScore W2107675168C181199279 @default.
• W2107675168 hasConceptScore W2107675168C185592680 @default.
• W2107675168 hasConceptScore W2107675168C203014093 @default.
• W2107675168 hasConceptScore W2107675168C2776217839 @default.
• W2107675168 hasConceptScore W2107675168C2777622882 @default.
• W2107675168 hasConceptScore W2107675168C2779219270 @default.
• W2107675168 hasConceptScore W2107675168C519581460 @default.
• W2107675168 hasConceptScore W2107675168C55493867 @default.
• W2107675168 hasConceptScore W2107675168C71924100 @default.
• W2107675168 hasConceptScore W2107675168C98274493 @default.
• W2107675168 hasIssue "2" @default.

• next