FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107694966> ?p ?o ?g. }

• W2107694966 endingPage "28" @default.
• W2107694966 startingPage "18" @default.
• W2107694966 abstract "Cerebral ischemia is one of the most common causes of disabilities in adults and leads to long-term motor and cognitive impairments with limited therapeutic possibilities. Treatment options have proven efficient in preclinical models of cerebral ischemia but have failed in the clinical setting. This limited translation may be due to the suitability of models used and outcomes measured as most studies have focused on the early period after injury with gross motor scales, which have limited correlation to the clinical situation. The aim of this study was to determine long-term functional outcomes after cerebral ischemia in rats, focusing on fine motor function, social and depressive behavior as clinically relevant measures. A secondary objective was to evaluate the effects of an anti-inflammatory treatment (interleukin-1 receptor antagonist (IL-1Ra)) on functional recovery and compensation. Infarct volume was correlated with long-term (25 days) impairments in fine motor skills, but not with emotional components of behavior. Motor impairments could not be detected using conventional neurological tests and only detailed analysis allowed differentiation between recovery and compensation. Acute systemic administration of IL-1Ra (at reperfusion) led to a faster and more complete recovery, but delayed (24h) IL-1Ra treatment had no effect. In summary functional assessment after brain injury requires detailed motor tests in order to address long-term impairments and compensation processes that are mediated by intact tissues. Functional deficits in skilled movement after brain injury represent ideal predictors of long-term outcomes and should become standard measures in the assessment of preclinical animal models." @default.
• W2107694966 created "2016-06-24" @default.
• W2107694966 creator A5001134449 @default.
• W2107694966 creator A5002623826 @default.
• W2107694966 creator A5006384918 @default.
• W2107694966 creator A5071191360 @default.
• W2107694966 creator A5089858629 @default.
• W2107694966 date "2014-08-01" @default.
• W2107694966 modified "2023-10-17" @default.
• W2107694966 title "Long-term functional recovery and compensation after cerebral ischemia in rats" @default.
• W2107694966 cites W1966702161 @default.
• W2107694966 cites W1970128583 @default.
• W2107694966 cites W1970516435 @default.
• W2107694966 cites W1978830885 @default.
• W2107694966 cites W1985726784 @default.
• W2107694966 cites W1987277853 @default.
• W2107694966 cites W1989475128 @default.
• W2107694966 cites W2001882876 @default.
• W2107694966 cites W2002427402 @default.
• W2107694966 cites W2012610329 @default.
• W2107694966 cites W2013186723 @default.
• W2107694966 cites W2019241796 @default.
• W2107694966 cites W2021715667 @default.
• W2107694966 cites W2025894081 @default.
• W2107694966 cites W2035335195 @default.
• W2107694966 cites W2039176792 @default.
• W2107694966 cites W2041136232 @default.
• W2107694966 cites W2041614350 @default.
• W2107694966 cites W2045421141 @default.
• W2107694966 cites W2050037580 @default.
• W2107694966 cites W2050645454 @default.
• W2107694966 cites W2065031308 @default.
• W2107694966 cites W2068658474 @default.
• W2107694966 cites W2070698839 @default.
• W2107694966 cites W2089854608 @default.
• W2107694966 cites W2104205224 @default.
• W2107694966 cites W2118610309 @default.
• W2107694966 cites W2119272666 @default.
• W2107694966 cites W2121158877 @default.
• W2107694966 cites W2126795224 @default.
• W2107694966 cites W2132453743 @default.
• W2107694966 cites W2141580911 @default.
• W2107694966 cites W2150543625 @default.
• W2107694966 cites W2160525623 @default.
• W2107694966 cites W2164978865 @default.
• W2107694966 cites W2170378836 @default.
• W2107694966 cites W2172042148 @default.
• W2107694966 cites W2333567675 @default.
• W2107694966 cites W4211191293 @default.
• W2107694966 cites W4292172722 @default.
• W2107694966 doi "https://doi.org/10.1016/j.bbr.2014.05.008" @default.
• W2107694966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4090421" @default.
• W2107694966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24821402" @default.
• W2107694966 hasPublicationYear "2014" @default.
• W2107694966 type Work @default.
• W2107694966 sameAs 2107694966 @default.
• W2107694966 citedByCount "28" @default.
• W2107694966 countsByYear W21076949662015 @default.
• W2107694966 countsByYear W21076949662016 @default.
• W2107694966 countsByYear W21076949662017 @default.
• W2107694966 countsByYear W21076949662018 @default.
• W2107694966 countsByYear W21076949662019 @default.
• W2107694966 countsByYear W21076949662020 @default.
• W2107694966 countsByYear W21076949662021 @default.
• W2107694966 countsByYear W21076949662022 @default.
• W2107694966 countsByYear W21076949662023 @default.
• W2107694966 crossrefType "journal-article" @default.
• W2107694966 hasAuthorship W2107694966A5001134449 @default.
• W2107694966 hasAuthorship W2107694966A5002623826 @default.
• W2107694966 hasAuthorship W2107694966A5006384918 @default.
• W2107694966 hasAuthorship W2107694966A5071191360 @default.
• W2107694966 hasAuthorship W2107694966A5089858629 @default.
• W2107694966 hasBestOaLocation W21076949661 @default.
• W2107694966 hasConcept C15744967 @default.
• W2107694966 hasConcept C164705383 @default.
• W2107694966 hasConcept C169760540 @default.
• W2107694966 hasConcept C541997718 @default.
• W2107694966 hasConcept C71924100 @default.
• W2107694966 hasConcept C99508421 @default.
• W2107694966 hasConceptScore W2107694966C15744967 @default.
• W2107694966 hasConceptScore W2107694966C164705383 @default.
• W2107694966 hasConceptScore W2107694966C169760540 @default.
• W2107694966 hasConceptScore W2107694966C541997718 @default.
• W2107694966 hasConceptScore W2107694966C71924100 @default.
• W2107694966 hasConceptScore W2107694966C99508421 @default.
• W2107694966 hasFunder F4320307874 @default.
• W2107694966 hasFunder F4320320291 @default.
• W2107694966 hasFunder F4320334593 @default.
• W2107694966 hasFunder F4320334626 @default.
• W2107694966 hasLocation W21076949661 @default.
• W2107694966 hasLocation W21076949662 @default.
• W2107694966 hasLocation W21076949663 @default.
• W2107694966 hasLocation W21076949664 @default.
• W2107694966 hasOpenAccess W2107694966 @default.
• W2107694966 hasPrimaryLocation W21076949661 @default.
• W2107694966 hasRelatedWork W1506200166 @default.
• W2107694966 hasRelatedWork W1995515455 @default.
• W2107694966 hasRelatedWork W2048182022 @default.

• next