FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107710089> ?p ?o ?g. }

• W2107710089 endingPage "258" @default.
• W2107710089 startingPage "252" @default.
• W2107710089 abstract "Argatroban is a peptidomimetic inhibitor of thrombin that is currently undergoing extensive clinical trials as a heparin substitute for thrombotic complications. Argatroban is readily metabolized into a major derivative, M1, that has pharmacological characteristics distinct from its parent compound. The currently available clot-based assays measure the cumulative anticoagulant effect of argatroban and its metabolite(s). Available HPLC methods do not differentiate between argatroban and M1-metabolite. A modified method was developed to simultaneouly quantitate M1-metabolite and argatroban in biological fluids. Initial validation studies for the method included clinical trials of argatroban in patients with heparin-induced thrombocytopenia, (ARG 911 Study) and coronary interventional procedures (ARG 310 Study). Plasma samples were extracted with acetonitrile and reconstituted in a mobile phase. Calibration curves were prepared by running known standards of argatroban and M1-metabolite in normal human plasma. Ultraviolet detection was made at 320 nm. The retention times for argatroban and M1-metabolite peaks were found to be 10.5 +/- 0.3 minutes and 3.9 +/- 0.1 minutes, respectively. The extraction efficiency was > 95% (r2 = 0.99). In heparin-induced thrombocytopenia patients with major bleeding complications (n = 30), the relative increase in M1-metabolite compared to argatroban varied widely (two- to eight-fold). The mean concentration of argatroban during the steady infusion period was found to be 0.7 +/- 0.35 microgram/mL, and for M1-metabolite, it was 5.5 +/- 2.8 micrograms/mL. Proportionate results were not seen when higher dosages of argatroban were administered (coronary angioplasty studies). Argatroban and M1-metabolite levels also compared well with the results in global clotting assays. Owing to the simultaneous quantitation of argatroban and M1-metabolite, this method provides a rapid assessment of the pharmacokinetics and pharmacodynamics of argatroban. The differential quantitation may be useful in the assessment of relative metabolic turnover of argatroban that can be related to the hepatic and renal functions in a given patient." @default.
• W2107710089 created "2016-06-24" @default.
• W2107710089 creator A5007859032 @default.
• W2107710089 creator A5030457785 @default.
• W2107710089 creator A5034121067 @default.
• W2107710089 creator A5040010155 @default.
• W2107710089 creator A5045931049 @default.
• W2107710089 creator A5055893524 @default.
• W2107710089 creator A5057890906 @default.
• W2107710089 creator A5074304553 @default.
• W2107710089 creator A5074532266 @default.
• W2107710089 date "1999-10-01" @default.
• W2107710089 modified "2023-09-29" @default.
• W2107710089 title "Simultaneous Monitoring of Argatroban and Its Major Metabolite Using an HPLC Method: Potential Clinical Applications" @default.
• W2107710089 cites W1977398058 @default.
• W2107710089 cites W2046300763 @default.
• W2107710089 cites W2054728105 @default.
• W2107710089 cites W2060297306 @default.
• W2107710089 cites W2081769864 @default.
• W2107710089 cites W2149133552 @default.
• W2107710089 cites W2166791856 @default.
• W2107710089 cites W2221015914 @default.
• W2107710089 cites W2274445622 @default.
• W2107710089 cites W2574782504 @default.
• W2107710089 cites W4251139957 @default.
• W2107710089 cites W4290987701 @default.
• W2107710089 doi "https://doi.org/10.1177/107602969900500409" @default.
• W2107710089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10726023" @default.
• W2107710089 hasPublicationYear "1999" @default.
• W2107710089 type Work @default.
• W2107710089 sameAs 2107710089 @default.
• W2107710089 citedByCount "17" @default.
• W2107710089 countsByYear W21077100892021 @default.
• W2107710089 countsByYear W21077100892023 @default.
• W2107710089 crossrefType "journal-article" @default.
• W2107710089 hasAuthorship W2107710089A5007859032 @default.
• W2107710089 hasAuthorship W2107710089A5030457785 @default.
• W2107710089 hasAuthorship W2107710089A5034121067 @default.
• W2107710089 hasAuthorship W2107710089A5040010155 @default.
• W2107710089 hasAuthorship W2107710089A5045931049 @default.
• W2107710089 hasAuthorship W2107710089A5055893524 @default.
• W2107710089 hasAuthorship W2107710089A5057890906 @default.
• W2107710089 hasAuthorship W2107710089A5074304553 @default.
• W2107710089 hasAuthorship W2107710089A5074532266 @default.
• W2107710089 hasConcept C126322002 @default.
• W2107710089 hasConcept C149151106 @default.
• W2107710089 hasConcept C2777292125 @default.
• W2107710089 hasConcept C2777477808 @default.
• W2107710089 hasConcept C2777557582 @default.
• W2107710089 hasConcept C2778205648 @default.
• W2107710089 hasConcept C2779612170 @default.
• W2107710089 hasConcept C71924100 @default.
• W2107710089 hasConcept C89560881 @default.
• W2107710089 hasConcept C98274493 @default.
• W2107710089 hasConceptScore W2107710089C126322002 @default.
• W2107710089 hasConceptScore W2107710089C149151106 @default.
• W2107710089 hasConceptScore W2107710089C2777292125 @default.
• W2107710089 hasConceptScore W2107710089C2777477808 @default.
• W2107710089 hasConceptScore W2107710089C2777557582 @default.
• W2107710089 hasConceptScore W2107710089C2778205648 @default.
• W2107710089 hasConceptScore W2107710089C2779612170 @default.
• W2107710089 hasConceptScore W2107710089C71924100 @default.
• W2107710089 hasConceptScore W2107710089C89560881 @default.
• W2107710089 hasConceptScore W2107710089C98274493 @default.
• W2107710089 hasIssue "4" @default.
• W2107710089 hasLocation W21077100891 @default.
• W2107710089 hasLocation W21077100892 @default.
• W2107710089 hasOpenAccess W2107710089 @default.
• W2107710089 hasPrimaryLocation W21077100891 @default.
• W2107710089 hasRelatedWork W1978597795 @default.
• W2107710089 hasRelatedWork W1989459865 @default.
• W2107710089 hasRelatedWork W2054730686 @default.
• W2107710089 hasRelatedWork W2073000894 @default.
• W2107710089 hasRelatedWork W2078186492 @default.
• W2107710089 hasRelatedWork W2081460129 @default.
• W2107710089 hasRelatedWork W2103247642 @default.
• W2107710089 hasRelatedWork W2107710089 @default.
• W2107710089 hasRelatedWork W2380159493 @default.
• W2107710089 hasRelatedWork W2380378136 @default.
• W2107710089 hasVolume "5" @default.
• W2107710089 isParatext "false" @default.
• W2107710089 isRetracted "false" @default.
• W2107710089 magId "2107710089" @default.
• W2107710089 workType "article" @default.