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- W2107714891 abstract "Benzo[c]phenanthridine skeleton was synthesized from easily available starting N-methyl-o-toluamide 2 and o-methylbenzonitrile 5 in 7 steps. Radical cyclization of styrene 10 afforded 6, 11-dimethyl-6, 11 -dihydro-5H-in-deno[1, 2-c]isoquinolin-5-one 13. Most 3-arylisoquinolines have displayed strong activities against human tumor cell lines. Especially, indenoisoquinolinone 13 exhibited excellent cytotoxicity (IC50=0.002 μg/ml; HCT 15)." @default.
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- W2107714891 date "1999-01-01" @default.
- W2107714891 modified "2023-10-02" @default.
- W2107714891 title "A Novel Synthesis of Benzo(c)phenanthridine Skeleton and Biological Evaluation of Isoquinoline Derivatives." @default.
- W2107714891 doi "https://doi.org/10.1248/cpb.47.900" @default.
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