Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107744185> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2107744185 endingPage "142" @default.
- W2107744185 startingPage "135" @default.
- W2107744185 abstract "The intestinal epithelium forms a barrier between the gut lumen and the body. The barrier is potentially challenged by the high turnover of epithelial cells being shed. Our laboratories have shown that the epithelium is punctuated by discontinuities called “gaps” that have the diameter of an epithelial cell and are devoid of cellular contents. At least a proportion of gaps are formed by the shedding of epithelial cells. These gaps are filled with an unknown substance that maintains local barrier function. Gaps have been identified in the mouse by in vivo confocal microscopy and in humans by confocal endomicroscopy. They can be distinguished from goblet cells by the absence of a nucleus and are found in Math1−/− mice where goblet cells are absent. Cell shedding and gap formation is increased by TNF‐α. Barrier function is lost after TNF‐α in approximately 20% of shedding events. These observations suggest that loss of barrier function at sites of cell shedding may be important in intestinal diseases where an increase in epithelial permeability plays a role in pathogenesis." @default.
- W2107744185 created "2016-06-24" @default.
- W2107744185 creator A5046711791 @default.
- W2107744185 creator A5049110134 @default.
- W2107744185 creator A5063664853 @default.
- W2107744185 creator A5090252236 @default.
- W2107744185 date "2009-05-01" @default.
- W2107744185 modified "2023-10-18" @default.
- W2107744185 title "Mechanisms of Epithelial Cell Shedding in the Mammalian Intestine and Maintenance of Barrier Function" @default.
- W2107744185 cites W1975523864 @default.
- W2107744185 cites W1982603620 @default.
- W2107744185 cites W1989506542 @default.
- W2107744185 cites W1990644839 @default.
- W2107744185 cites W1993184653 @default.
- W2107744185 cites W1996543394 @default.
- W2107744185 cites W2005690646 @default.
- W2107744185 cites W2067386697 @default.
- W2107744185 cites W2067526109 @default.
- W2107744185 cites W2068704289 @default.
- W2107744185 cites W2073723117 @default.
- W2107744185 cites W2084961029 @default.
- W2107744185 cites W2108706113 @default.
- W2107744185 cites W2109450749 @default.
- W2107744185 cites W2111170225 @default.
- W2107744185 cites W2114469936 @default.
- W2107744185 cites W2119331847 @default.
- W2107744185 cites W2121288935 @default.
- W2107744185 cites W2125311914 @default.
- W2107744185 cites W2130157754 @default.
- W2107744185 cites W2141710693 @default.
- W2107744185 cites W2148459495 @default.
- W2107744185 cites W2168834895 @default.
- W2107744185 cites W2411372610 @default.
- W2107744185 cites W2414675254 @default.
- W2107744185 doi "https://doi.org/10.1111/j.1749-6632.2009.04027.x" @default.
- W2107744185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19538298" @default.
- W2107744185 hasPublicationYear "2009" @default.
- W2107744185 type Work @default.
- W2107744185 sameAs 2107744185 @default.
- W2107744185 citedByCount "77" @default.
- W2107744185 countsByYear W21077441852012 @default.
- W2107744185 countsByYear W21077441852013 @default.
- W2107744185 countsByYear W21077441852014 @default.
- W2107744185 countsByYear W21077441852015 @default.
- W2107744185 countsByYear W21077441852016 @default.
- W2107744185 countsByYear W21077441852017 @default.
- W2107744185 countsByYear W21077441852018 @default.
- W2107744185 countsByYear W21077441852019 @default.
- W2107744185 countsByYear W21077441852020 @default.
- W2107744185 countsByYear W21077441852021 @default.
- W2107744185 countsByYear W21077441852022 @default.
- W2107744185 countsByYear W21077441852023 @default.
- W2107744185 crossrefType "journal-article" @default.
- W2107744185 hasAuthorship W2107744185A5046711791 @default.
- W2107744185 hasAuthorship W2107744185A5049110134 @default.
- W2107744185 hasAuthorship W2107744185A5063664853 @default.
- W2107744185 hasAuthorship W2107744185A5090252236 @default.
- W2107744185 hasConcept C2779178360 @default.
- W2107744185 hasConcept C2781077229 @default.
- W2107744185 hasConcept C51911345 @default.
- W2107744185 hasConcept C529295009 @default.
- W2107744185 hasConcept C54355233 @default.
- W2107744185 hasConcept C86803240 @default.
- W2107744185 hasConcept C95444343 @default.
- W2107744185 hasConceptScore W2107744185C2779178360 @default.
- W2107744185 hasConceptScore W2107744185C2781077229 @default.
- W2107744185 hasConceptScore W2107744185C51911345 @default.
- W2107744185 hasConceptScore W2107744185C529295009 @default.
- W2107744185 hasConceptScore W2107744185C54355233 @default.
- W2107744185 hasConceptScore W2107744185C86803240 @default.
- W2107744185 hasConceptScore W2107744185C95444343 @default.
- W2107744185 hasIssue "1" @default.
- W2107744185 hasLocation W21077441851 @default.
- W2107744185 hasLocation W21077441852 @default.
- W2107744185 hasOpenAccess W2107744185 @default.
- W2107744185 hasPrimaryLocation W21077441851 @default.
- W2107744185 hasRelatedWork W1977847393 @default.
- W2107744185 hasRelatedWork W2080357629 @default.
- W2107744185 hasRelatedWork W2415364605 @default.
- W2107744185 hasRelatedWork W2470022848 @default.
- W2107744185 hasRelatedWork W2471678620 @default.
- W2107744185 hasRelatedWork W2472352382 @default.
- W2107744185 hasRelatedWork W2548712946 @default.
- W2107744185 hasRelatedWork W2553323458 @default.
- W2107744185 hasRelatedWork W2777816467 @default.
- W2107744185 hasRelatedWork W4225369864 @default.
- W2107744185 hasVolume "1165" @default.
- W2107744185 isParatext "false" @default.
- W2107744185 isRetracted "false" @default.
- W2107744185 magId "2107744185" @default.
- W2107744185 workType "article" @default.