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• W2107745828 endingPage "C164" @default.
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• W2107745828 abstract "We investigated the effects of 5,6-dichloro-1-ethyl-1,3-dihydro-2 H-benzimidazol-2-one(DCEBIO) on the Cl − secretory response of the mouse jejunum using the Ussing short-circuit current ( I sc ) technique. DCEBIO stimulated a concentration-dependent, sustained increase in I sc (EC 50 41 ± 1 μM). Pretreating tissues with 0.25 μM forskolin reduced the concentration-dependent increase in I sc by DCEBIO and increased the EC 50 (53 ± 5 μM). Bumetanide blocked (82 ± 5%) the DCEBIO-stimulated I sc consistent with Cl − secretion. DCEBIO was a more potent stimulator of Cl − secretion than its parent molecule, 1-ethyl-2-benzimidazolinone. Glibenclamide or NPPB reduced the DCEBIO-stimulated I sc by >80% indicating the participation of CFTR in the DCEBIO-stimulated I sc response. Clotrimazole reduced DCEBIO-stimulated I sc by 67 ± 15%, suggesting the participation of the intermediate conductance Ca 2+ -activated K + channel (IK Ca ) in the DCEBIO-activated I sc response. In the presence of maximum forskolin (10 μM), the DCEBIO response was reduced and biphasic, reaching a peak response of the change in I sc of 43 ± 5 μA/cm 2 and then falling to a steady-state response of 17 ± 10 μA/cm 2 compared with DCEBIO control tissues (61 ± 6 μA/cm 2 ). The forskolin-stimulated I sc in the presence of DCEBIO was reduced compared with forskolin control tissues. Similar results were observed with DCEBIO and 8-BrcAMP where adenylate cyclase was bypassed. H89, a PKA inhibitor, reduced the DCEBIO-activated I sc , providing evidence that DCEBIO increased Cl − secretion via a cAMP/PKA-dependent manner. These data suggest that DCEBIO stimulates Cl − secretion of the mouse jejunum and that DCEBIO targets components of the Cl − secretory mechanism." @default.
• W2107745828 created "2016-06-24" @default.
• W2107745828 creator A5029410306 @default.
• W2107745828 creator A5066775052 @default.
• W2107745828 date "2006-01-01" @default.
• W2107745828 modified "2023-10-16" @default.
• W2107745828 title "DCEBIO stimulates Cl⁻secretion in the mouse jejunum" @default.
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• W2107745828 doi "https://doi.org/10.1152/ajpcell.00187.2005" @default.
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