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• W2107764983 abstract "Abstract Purpose: In this study, we examine the immunomodulatory effects and antitumor activity of tamoxifen and letrozole when combined with the human epithelial mucin (hMUC1)-specific vaccine, L-BLP25, in the hMUC1-expressing mammary tumor (MMT) mouse model. Experimental Design: Dose-finding studies were conducted for both tamoxifen and letrozole. Letrozole and L-BLP25 combination studies used 69 MMT female mice assigned to five groups: untreated, cyclophosphamide + placebo, cyclophosphamide + L-BLP25, letrozole 0.8 mg/kg, and cyclophosphamide + L-BLP25 + letrozole. Tamoxifen and L-BLP25 combination studies used 48 MMT female mice assigned to five treatment groups: untreated, cyclophosphamide + placebo, cyclophosphamide + L-BLP25, tamoxifen 50 mg/kg, and cyclophosphamide + L-BLP25 + tamoxifen 50 mg/kg group. Mice were injected subcutaneously with L-BLP25 (10 μg) weekly for 8 weeks. Serum cytokines were serially measured using a Luminex assay, whereas splenocytes at termination were analyzed by ELISpot to determine T-helper (TH)1/TH2 polarization of immune response. Results: Daily oral doses of 50 and 0.8 mg/kg of tamoxifen and letrozole, respectively, resulted in a significant survival advantage over controls (P &lt; 0.05). A predominant TH1-polarized immune response in vaccinated mice was seen with or without tamoxifen or letrozole treatments. In the L-BLP25 plus letrozole treatment group, statistically significant (P &lt; 0.05) additive antitumor activity was observed, whereas tamoxifen plus L-BLP25 was not significantly different (P &gt; 0.05). Conclusion: The results of this study show that hormonal therapy does not interfere with L-BLP25–induced predominant TH1 response, and the combination of L-BLP25 with letrozole has additive antitumor activity in the MMT mouse model. Clin Cancer Res; 18(10); 2861–71. ©2012 AACR." @default.
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• W2107764983 date "2012-05-14" @default.
• W2107764983 modified "2023-10-17" @default.
• W2107764983 title "L-BLP25 Vaccine plus Letrozole Induces a TH1 Immune Response and Has Additive Antitumor Activity in MUC1-Expressing Mammary Tumors in Mice" @default.
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• W2107764983 doi "https://doi.org/10.1158/1078-0432.ccr-12-0168" @default.
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