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• W2107768668 abstract "HomeHypertensionVol. 23, No. 1_supplementAlteration of response to neuropeptide Y in the nucleus tractus solitarius of spontaneously hypertensive rats. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBAlteration of response to neuropeptide Y in the nucleus tractus solitarius of spontaneously hypertensive rats. T Takesako, K Takeda, T Kuwahara, K Takenaka, M Tanaka, H Itoh, T Nakata, S Sasaki and M Nakagawa T TakesakoT Takesako Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan. Search for more papers by this author , K TakedaK Takeda Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan. Search for more papers by this author , T KuwaharaT Kuwahara Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan. Search for more papers by this author , K TakenakaK Takenaka Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan. Search for more papers by this author , M TanakaM Tanaka Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan. Search for more papers by this author , H ItohH Itoh Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan. Search for more papers by this author , T NakataT Nakata Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan. Search for more papers by this author , S SasakiS Sasaki Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan. Search for more papers by this author and M NakagawaM Nakagawa Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan. Search for more papers by this author Originally published1 Jan 1994https://doi.org/10.1161/01.HYP.23.1_Suppl.I93Hypertension. 1994;23AbstractIn normotensive rats, microinjections of neuropeptide Y (2.5 to 25 pmol) into the unilateral nucleus tractus solitarius elicited dose-dependent vasodepressor and bradycardiac responses accompanied by an inhibition of sympathetic nerve firing. After microinjections of the alpha 2-adrenergic receptor antagonist yohimbine (100 ng) into the nucleus tractus solitarius, the depressor and bradycardic responses to the injection of neuropeptide Y (25 pmol) into the nucleus tractus solitarius were significantly attenuated. In contrast, pretreatment with the alpha 1-adrenergic receptor antagonist doxazosin (200 ng) injected into the nucleus tractus solitarius did not alter these responses. In spontaneously hypertensive rats, microinjections of neuropeptide Y (25 pmol) into the nucleus tractus solitarius also elicited depressor and bradycardic responses that were significantly less than those of normotensive Wistar-Kyoto rats. However, pretreatment with yohimbine (100 ng) in the nucleus tractus solitarius did not diminish these depressor responses in spontaneously hypertensive rats. Depressor responses to neuropeptide Y, which was administered after yohimbine pretreatment, were also less in Wistar-Kyoto rats than in spontaneously hypertensive rats. The results suggest that the depressor and bradycardic responses elicited by neuropeptide Y were accompanied by the inhibition of sympathetic nerve activity. These responses may be mediated in part by alpha 2-adrenergic receptor in the nucleus tractus solitarius. The impairment of alpha 2-adrenergic receptor-mediated responses to neuropeptide Y in spontaneously hypertensive rats may contribute to the development of hypertension. Previous Back to top Next FiguresReferencesRelatedDetailsCited By Westfall T Neuropeptide Y and sympathetic control of vascular tone in hypertension NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics, 10.1007/3-7643-7417-9_6, (89-103) Agrotis A (2005) The genetic basis for altered blood vessel function in disease: large artery stiffening, Vascular Health and Risk Management, 10.2147/vhrm.2005.1.4.333, 1:4, (333-344), Online publication date: 1-Apr-2005. Sweerts B, Jarrott B and Lawrence A (2001) The Effect of Acute and Chronic Restraint on the Central Expression of Prepro-Neuropeptide Y mRNA in Normotensive and Hypertensive Rats, Journal of Neuroendocrinology, 10.1046/j.1365-2826.2001.00674.x, 13:7, (608-617), Online publication date: 1-Jul-2001. Morimoto S, Sasaki S, Miki S, Kawa T, Nakamura K, Itoh H, Nakata T, Takeda K, Nakagawa M and Fushiki S (2000) Nitric oxide is an excitatory modulator in the rostral ventrolateral medulla in rats, American Journal of Hypertension, 10.1016/S0895-7061(00)01182-1, 13:10, (1125-1134), Online publication date: 1-Oct-2000. Lee C and Miller R (1998) Is there really an NPY Y3 receptor?, Regulatory Peptides, 10.1016/S0167-0115(98)00054-8, 75-76, (71-78), Online publication date: 1-Sep-1998. Morris M, Hastings J and Pavia J (2009) Centtral Interactions Between Noradrenaline and Neuropeptide Y in the Rat: Implications for Blood Pressure Control, Clinical and Experimental Hypertension, 10.3109/10641969709083174, 19:5-6, (619-630), Online publication date: 1-Jan-1997. Aguirre J, Hedlund P, Narváez J, Bunnemann B, Ganten D and Fuxe K (1995) Increased vasopressor actions of intraventricular neuropeptide Y-(13–36) in spontaneously hypertensive versus normotensive Wistar-Kyoto rats. Possible relationship to increases in Y2 receptor binding in the nucleus tractus solitarius, Brain Research, 10.1016/0006-8993(95)00408-I, 684:2, (159-164), Online publication date: 1-Jul-1995. January 1994Vol 23, Issue 1_supplement Advertisement Article InformationMetrics Copyright © 1994 by American Heart Associationhttps://doi.org/10.1161/01.HYP.23.1_Suppl.I93PMID: 8282383 Originally publishedJanuary 1, 1994 PDF download Advertisement" @default.
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