FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107792904> ?p ?o ?g. }

• W2107792904 endingPage "1474" @default.
• W2107792904 startingPage "1463" @default.
• W2107792904 abstract "Glucocorticoid hormones regulate the post-translational maturation and sorting of cell surface and extracellular mouse mammary tumor virus (MMTV) glycoproteins in M1.54 cells, a stably infected rat hepatoma cell line. Exposure to monensin significantly reduced the proteolytic maturation and externalization of viral glycoproteins resulting in a stable cellular accumulation of a single 70,000-Mr glycosylated polyprotein (designated gp70). Cell surface- and intracellular-specific immunoprecipitations of monensin-treated cells revealed that gp70 can be localized to the cell surface only in the presence of 1 microM dexamethasone, while in uninduced cells gp70 is irreversibly sequestered in an intracellular compartment. Analysis of oligosaccharide processing kinetics demonstrated that gp70 acquired resistance to endoglycosidase H with a half-time of 65 min in the presence or absence of hormone. In contrast, gp70 was inefficiently galactosylated after a 60-min lag in uninduced cells while rapidly acquiring this carbohydrate modification in the presence of dexamethasone. Furthermore, in the absence or presence of monensin, MMTV glycoproteins failed to be galactosylated in hormone-induced CR4 cells, a complement-selected sorting variant defective in the glucocorticoid-regulated compartmentalization of viral glycoproteins to the cell surface. Since dexamethasone had no apparent global effects on organelle morphology or production of total cell surface-galactosylated species, we conclude that glucocorticoids induce the localization of cell surface MMTV glycoproteins by regulating a highly selective step within the Golgi apparatus after the acquisition of endoglycosidase H-resistant oligosaccharide side chains but before or at the site of galactose attachment." @default.
• W2107792904 created "2016-06-24" @default.
• W2107792904 creator A5022180749 @default.
• W2107792904 creator A5023224521 @default.
• W2107792904 creator A5058320924 @default.
• W2107792904 creator A5058807669 @default.
• W2107792904 creator A5060192450 @default.
• W2107792904 creator A5023724726 @default.
• W2107792904 date "1988-05-01" @default.
• W2107792904 modified "2023-09-26" @default.
• W2107792904 title "Glucocorticoid-regulated localization of cell surface glycoproteins in rat hepatoma cells is mediated within the Golgi complex." @default.
• W2107792904 cites W1485388309 @default.
• W2107792904 cites W1496336749 @default.
• W2107792904 cites W1524415594 @default.
• W2107792904 cites W153456208 @default.
• W2107792904 cites W1606423922 @default.
• W2107792904 cites W1799849637 @default.
• W2107792904 cites W1815338450 @default.
• W2107792904 cites W1817464234 @default.
• W2107792904 cites W1818020384 @default.
• W2107792904 cites W1975072414 @default.
• W2107792904 cites W1985289297 @default.
• W2107792904 cites W1999979628 @default.
• W2107792904 cites W2000359601 @default.
• W2107792904 cites W2002164494 @default.
• W2107792904 cites W2002527250 @default.
• W2107792904 cites W2003935639 @default.
• W2107792904 cites W2004416191 @default.
• W2107792904 cites W2004499911 @default.
• W2107792904 cites W2006943139 @default.
• W2107792904 cites W2008013667 @default.
• W2107792904 cites W2011985054 @default.
• W2107792904 cites W2013459359 @default.
• W2107792904 cites W2016417523 @default.
• W2107792904 cites W2017757823 @default.
• W2107792904 cites W2018289835 @default.
• W2107792904 cites W2018327863 @default.
• W2107792904 cites W2021785970 @default.
• W2107792904 cites W2024469375 @default.
• W2107792904 cites W2027407556 @default.
• W2107792904 cites W2031149217 @default.
• W2107792904 cites W2031656934 @default.
• W2107792904 cites W2046389334 @default.
• W2107792904 cites W2056917962 @default.
• W2107792904 cites W2058302315 @default.
• W2107792904 cites W2062360693 @default.
• W2107792904 cites W2066719256 @default.
• W2107792904 cites W2071168485 @default.
• W2107792904 cites W2071427211 @default.
• W2107792904 cites W2076109789 @default.
• W2107792904 cites W2083263961 @default.
• W2107792904 cites W2083668173 @default.
• W2107792904 cites W2084392102 @default.
• W2107792904 cites W2084799821 @default.
• W2107792904 cites W2087492212 @default.
• W2107792904 cites W2088819006 @default.
• W2107792904 cites W2092057385 @default.
• W2107792904 cites W2094706331 @default.
• W2107792904 cites W2100837269 @default.
• W2107792904 cites W2104360623 @default.
• W2107792904 cites W2109513679 @default.
• W2107792904 cites W2124287787 @default.
• W2107792904 cites W2126979211 @default.
• W2107792904 cites W2138623532 @default.
• W2107792904 cites W2139737536 @default.
• W2107792904 cites W2149736282 @default.
• W2107792904 cites W2152410168 @default.
• W2107792904 cites W2152708819 @default.
• W2107792904 cites W2172867362 @default.
• W2107792904 cites W2174107598 @default.
• W2107792904 cites W2174158153 @default.
• W2107792904 cites W2174160083 @default.
• W2107792904 cites W2422423626 @default.
• W2107792904 doi "https://doi.org/10.1083/jcb.106.5.1463" @default.
• W2107792904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2115045" @default.
• W2107792904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2836430" @default.
• W2107792904 hasPublicationYear "1988" @default.
• W2107792904 type Work @default.
• W2107792904 sameAs 2107792904 @default.
• W2107792904 citedByCount "27" @default.
• W2107792904 crossrefType "journal-article" @default.
• W2107792904 hasAuthorship W2107792904A5022180749 @default.
• W2107792904 hasAuthorship W2107792904A5023224521 @default.
• W2107792904 hasAuthorship W2107792904A5023724726 @default.
• W2107792904 hasAuthorship W2107792904A5058320924 @default.
• W2107792904 hasAuthorship W2107792904A5058807669 @default.
• W2107792904 hasAuthorship W2107792904A5060192450 @default.
• W2107792904 hasBestOaLocation W21077929041 @default.
• W2107792904 hasConcept C108625454 @default.
• W2107792904 hasConcept C119062480 @default.
• W2107792904 hasConcept C153911025 @default.
• W2107792904 hasConcept C158617107 @default.
• W2107792904 hasConcept C2779571893 @default.
• W2107792904 hasConcept C2780224938 @default.
• W2107792904 hasConcept C2780654058 @default.
• W2107792904 hasConcept C2781373781 @default.
• W2107792904 hasConcept C28406088 @default.
• W2107792904 hasConcept C54355233 @default.

• next