FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107796877> ?p ?o ?g. }

• W2107796877 endingPage "73" @default.
• W2107796877 startingPage "67" @default.
• W2107796877 abstract "The effect of antihypertensive medications on cognitive function has not been well studied. The authors' objectives were to investigate the cross-sectional and longitudinal association between the use of antihypertensive medications and cognitive function and to compare different antihypertensive medication classes with regard to this association in an elderly population.The medical records of a convenience sample of patients (n = 993 cross-sectional and 350 longitudinal; mean age, 76.8 +/- 0.3 years; 74% women; 87% White) followed at a geriatric practice were reviewed. Data abstracted included demographics, medical history (Alzheimer's disease [AD] or vascular dementia [VaD]), use of antihypertensive medications, and results of cognitive assessments (the Mini-Mental Status Examination [MMSE] and the Clock Draw Test [CDT]).In the cross-sectional analysis, antihypertensive use was not associated with MMSE (p >.05), CDT (p >.05), or dementia diagnosis (odds ratio for AD, 0.8; 95% confidence interval [CI], 0.6 to 1.2; odds ratio for VaD, 1.6; 95% CI, 0.6 to 4.0). In the longitudinal analysis, antihypertensive use was associated with a lower rate of cognitive decline on the MMSE (-0.8 +/- 2 points in users vs -5.8 +/- 2.5 points in nonusers; p =.007) and on the CDT (-0.3 +/- 0.8 points in users vs -2.2 +/- 0.8 points in nonusers; p =.002), and with a lower risk for the development of cognitive impairment (odds ratio, 0.56; 95% CI, 0.38 to 0.83; p =.004). The trend was similar in patients with baseline AD (p =.02). Patients taking diuretics (p =.007), angiotensin-converting enzyme inhibitors (p =.016), and beta-blockers (p =.014) had a lower rate of cognitive decline, and patients taking angiotensin receptor blockers (p =.016) had improved cognitive scores.Antihypertensive use, particularly diuretics, angiotensin-converting enzymes inhibitors, beta-blockers, and angiotensin receptor blockers, may be associated with a lower rate of cognitive decline in older adults, including those with AD. Until a randomized clinical trial confirms our results, findings of this observational study should be interpreted with caution." @default.
• W2107796877 created "2016-06-24" @default.
• W2107796877 creator A5018051446 @default.
• W2107796877 creator A5026958401 @default.
• W2107796877 creator A5035175263 @default.
• W2107796877 creator A5042568934 @default.
• W2107796877 creator A5047875760 @default.
• W2107796877 creator A5059952466 @default.
• W2107796877 creator A5083861134 @default.
• W2107796877 creator A5086977926 @default.
• W2107796877 date "2005-01-01" @default.
• W2107796877 modified "2023-09-27" @default.
• W2107796877 title "Cross-Sectional and Longitudinal Association Between Antihypertensive Medications and Cognitive Impairment in an Elderly Population" @default.
• W2107796877 cites W1505426793 @default.
• W2107796877 cites W1847168837 @default.
• W2107796877 cites W1903404096 @default.
• W2107796877 cites W1918420740 @default.
• W2107796877 cites W1992998861 @default.
• W2107796877 cites W2004517356 @default.
• W2107796877 cites W2005030033 @default.
• W2107796877 cites W2007725897 @default.
• W2107796877 cites W2030261100 @default.
• W2107796877 cites W2031645622 @default.
• W2107796877 cites W2033439000 @default.
• W2107796877 cites W2034897558 @default.
• W2107796877 cites W2040699222 @default.
• W2107796877 cites W2047864484 @default.
• W2107796877 cites W2054826663 @default.
• W2107796877 cites W2056199568 @default.
• W2107796877 cites W2060926663 @default.
• W2107796877 cites W2065927779 @default.
• W2107796877 cites W2065965622 @default.
• W2107796877 cites W2073735186 @default.
• W2107796877 cites W2088396659 @default.
• W2107796877 cites W2095377585 @default.
• W2107796877 cites W2097072982 @default.
• W2107796877 cites W2104565625 @default.
• W2107796877 cites W2105816186 @default.
• W2107796877 cites W2148466500 @default.
• W2107796877 cites W2151080792 @default.
• W2107796877 cites W2152907424 @default.
• W2107796877 cites W2155044939 @default.
• W2107796877 cites W2159824297 @default.
• W2107796877 cites W2162680540 @default.
• W2107796877 cites W2269243341 @default.
• W2107796877 cites W4254141223 @default.
• W2107796877 cites W4319425452 @default.
• W2107796877 cites W85196187 @default.
• W2107796877 doi "https://doi.org/10.1093/gerona/60.1.67" @default.
• W2107796877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15741285" @default.
• W2107796877 hasPublicationYear "2005" @default.
• W2107796877 type Work @default.
• W2107796877 sameAs 2107796877 @default.
• W2107796877 citedByCount "80" @default.
• W2107796877 countsByYear W21077968772012 @default.
• W2107796877 countsByYear W21077968772013 @default.
• W2107796877 countsByYear W21077968772014 @default.
• W2107796877 countsByYear W21077968772015 @default.
• W2107796877 countsByYear W21077968772016 @default.
• W2107796877 countsByYear W21077968772017 @default.
• W2107796877 countsByYear W21077968772018 @default.
• W2107796877 countsByYear W21077968772019 @default.
• W2107796877 countsByYear W21077968772020 @default.
• W2107796877 countsByYear W21077968772021 @default.
• W2107796877 countsByYear W21077968772022 @default.
• W2107796877 countsByYear W21077968772023 @default.
• W2107796877 crossrefType "journal-article" @default.
• W2107796877 hasAuthorship W2107796877A5018051446 @default.
• W2107796877 hasAuthorship W2107796877A5026958401 @default.
• W2107796877 hasAuthorship W2107796877A5035175263 @default.
• W2107796877 hasAuthorship W2107796877A5042568934 @default.
• W2107796877 hasAuthorship W2107796877A5047875760 @default.
• W2107796877 hasAuthorship W2107796877A5059952466 @default.
• W2107796877 hasAuthorship W2107796877A5083861134 @default.
• W2107796877 hasAuthorship W2107796877A5086977926 @default.
• W2107796877 hasConcept C126322002 @default.
• W2107796877 hasConcept C142052008 @default.
• W2107796877 hasConcept C142724271 @default.
• W2107796877 hasConcept C156957248 @default.
• W2107796877 hasConcept C1862650 @default.
• W2107796877 hasConcept C2777895361 @default.
• W2107796877 hasConcept C2779134260 @default.
• W2107796877 hasConcept C2779483572 @default.
• W2107796877 hasConcept C2908647359 @default.
• W2107796877 hasConcept C44249647 @default.
• W2107796877 hasConcept C71924100 @default.
• W2107796877 hasConcept C99454951 @default.
• W2107796877 hasConceptScore W2107796877C126322002 @default.
• W2107796877 hasConceptScore W2107796877C142052008 @default.
• W2107796877 hasConceptScore W2107796877C142724271 @default.
• W2107796877 hasConceptScore W2107796877C156957248 @default.
• W2107796877 hasConceptScore W2107796877C1862650 @default.
• W2107796877 hasConceptScore W2107796877C2777895361 @default.
• W2107796877 hasConceptScore W2107796877C2779134260 @default.
• W2107796877 hasConceptScore W2107796877C2779483572 @default.
• W2107796877 hasConceptScore W2107796877C2908647359 @default.
• W2107796877 hasConceptScore W2107796877C44249647 @default.
• W2107796877 hasConceptScore W2107796877C71924100 @default.

• next