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• W2107802984 abstract "The Otx2 gene encodes a transcription factor essential for the normal development of brain, cerebellum, pineal gland, and eye. In the retina, Otx2 has essential functions from early embryogenesis to adulthood. As soon as the optic vesicle is formed, the gene is required for retinal pigment epithelium specification. Otx2 is also a key regulator of photoreceptor genesis and differentiation, and is required after birth for bipolar cells terminal maturation. Otx2 expression is maintained in the differentiated retina wherein the gene is critical for the outer retina maintenance. In the visual cortex, the gene modulates the neuronal plasticity through a paracrine mechanism. OTX2 heterozygous mutations in humans have been linked to severe ocular malformations associated with brain abnormalities and pituitary dysfunction. Recent studies have also established the OTX2 gene as an oncogene for medulloblastoma, a malignant brain tumour originating in the cerebellum." @default.
• W2107802984 created "2016-06-24" @default.
• W2107802984 creator A5039920194 @default.
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• W2107802984 date "2013-06-01" @default.
• W2107802984 modified "2023-09-26" @default.
• W2107802984 title "The homeobox gene Otx2 in development and disease" @default.
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• W2107802984 doi "https://doi.org/10.1016/j.exer.2013.03.007" @default.
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