FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107834145> ?p ?o ?g. }

• W2107834145 endingPage "1473" @default.
• W2107834145 startingPage "1464" @default.
• W2107834145 abstract "Background. Based on a hollow-fiber system model of tuberculosis, we hypothesize that microbiologic failure and acquired drug resistance are primarily driven by low drug concentrations that result from pharmacokinetic variability. Methods. Clinical and pharmacokinetic data were prospectively collected from 142 tuberculosis patients in Western Cape, South Africa. Compartmental pharmacokinetic parameters of isoniazid, rifampin, and pyrazinamide were identified for each patient. Patients were then followed for up to 2 years. Classification and regression tree analysis was used to identify and rank clinical predictors of poor long-term outcome such as microbiologic failure or death, or relapse. Results. Drug concentrations and pharmacokinetics varied widely between patients. Poor long-term outcomes were encountered in 35 (25%) patients. The 3 top predictors of poor long-term outcome, by rank of importance, were a pyrazinamide 24-hour area under the concentration–time curve (AUC) ≤ 363 mg·h/L, rifampin AUC ≤ 13 mg·h/L, and isoniazid AUC ≤ 52 mg·h/L. Poor outcomes were encountered in 32/78 patients with the AUC of at least 1 drug below the identified threshold vs 3/64 without (odds ratio = 14.14; 95% confidence interval, 4.08–49.08). Low rifampin and isoniazid peak and AUC concentrations preceded all cases of acquired drug resistance. Conclusions. Low drug AUCs are predictive of clinical outcomes in tuberculosis patients." @default.
• W2107834145 created "2016-06-24" @default.
• W2107834145 creator A5013508569 @default.
• W2107834145 creator A5025069184 @default.
• W2107834145 creator A5025165126 @default.
• W2107834145 creator A5073520677 @default.
• W2107834145 creator A5080477180 @default.
• W2107834145 creator A5086010206 @default.
• W2107834145 date "2013-07-29" @default.
• W2107834145 modified "2023-10-02" @default.
• W2107834145 title "Serum Drug Concentrations Predictive of Pulmonary Tuberculosis Outcomes" @default.
• W2107834145 cites W1489900818 @default.
• W2107834145 cites W1820399389 @default.
• W2107834145 cites W1963625941 @default.
• W2107834145 cites W1977608714 @default.
• W2107834145 cites W2003971315 @default.
• W2107834145 cites W2006392678 @default.
• W2107834145 cites W2006641920 @default.
• W2107834145 cites W2029728996 @default.
• W2107834145 cites W2039786149 @default.
• W2107834145 cites W2042333540 @default.
• W2107834145 cites W2059910767 @default.
• W2107834145 cites W2060626299 @default.
• W2107834145 cites W2069097099 @default.
• W2107834145 cites W2097133372 @default.
• W2107834145 cites W2098049342 @default.
• W2107834145 cites W2100383609 @default.
• W2107834145 cites W2100501976 @default.
• W2107834145 cites W2102855070 @default.
• W2107834145 cites W2116200710 @default.
• W2107834145 cites W2117466548 @default.
• W2107834145 cites W2120343562 @default.
• W2107834145 cites W2122682841 @default.
• W2107834145 cites W2132793435 @default.
• W2107834145 cites W2134490126 @default.
• W2107834145 cites W2141228465 @default.
• W2107834145 cites W2142486974 @default.
• W2107834145 cites W2144425106 @default.
• W2107834145 cites W2147052474 @default.
• W2107834145 cites W2147213334 @default.
• W2107834145 cites W2147574313 @default.
• W2107834145 cites W2150589034 @default.
• W2107834145 cites W2150776537 @default.
• W2107834145 cites W2151487264 @default.
• W2107834145 cites W2163899436 @default.
• W2107834145 cites W2167415332 @default.
• W2107834145 cites W2172137232 @default.
• W2107834145 cites W2418210342 @default.
• W2107834145 cites W4206829609 @default.
• W2107834145 doi "https://doi.org/10.1093/infdis/jit352" @default.
• W2107834145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3789573" @default.
• W2107834145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23901086" @default.
• W2107834145 hasPublicationYear "2013" @default.
• W2107834145 type Work @default.
• W2107834145 sameAs 2107834145 @default.
• W2107834145 citedByCount "344" @default.
• W2107834145 countsByYear W21078341452013 @default.
• W2107834145 countsByYear W21078341452014 @default.
• W2107834145 countsByYear W21078341452015 @default.
• W2107834145 countsByYear W21078341452016 @default.
• W2107834145 countsByYear W21078341452017 @default.
• W2107834145 countsByYear W21078341452018 @default.
• W2107834145 countsByYear W21078341452019 @default.
• W2107834145 countsByYear W21078341452020 @default.
• W2107834145 countsByYear W21078341452021 @default.
• W2107834145 countsByYear W21078341452022 @default.
• W2107834145 countsByYear W21078341452023 @default.
• W2107834145 crossrefType "journal-article" @default.
• W2107834145 hasAuthorship W2107834145A5013508569 @default.
• W2107834145 hasAuthorship W2107834145A5025069184 @default.
• W2107834145 hasAuthorship W2107834145A5025165126 @default.
• W2107834145 hasAuthorship W2107834145A5073520677 @default.
• W2107834145 hasAuthorship W2107834145A5080477180 @default.
• W2107834145 hasAuthorship W2107834145A5086010206 @default.
• W2107834145 hasBestOaLocation W21078341451 @default.
• W2107834145 hasConcept C112705442 @default.
• W2107834145 hasConcept C114851261 @default.
• W2107834145 hasConcept C126322002 @default.
• W2107834145 hasConcept C142724271 @default.
• W2107834145 hasConcept C156957248 @default.
• W2107834145 hasConcept C2776967927 @default.
• W2107834145 hasConcept C2778607973 @default.
• W2107834145 hasConcept C2780035454 @default.
• W2107834145 hasConcept C2780272996 @default.
• W2107834145 hasConcept C2780459521 @default.
• W2107834145 hasConcept C2781069245 @default.
• W2107834145 hasConcept C44249647 @default.
• W2107834145 hasConcept C71924100 @default.
• W2107834145 hasConcept C76318530 @default.
• W2107834145 hasConcept C86803240 @default.
• W2107834145 hasConcept C89423630 @default.
• W2107834145 hasConcept C98274493 @default.
• W2107834145 hasConceptScore W2107834145C112705442 @default.
• W2107834145 hasConceptScore W2107834145C114851261 @default.
• W2107834145 hasConceptScore W2107834145C126322002 @default.
• W2107834145 hasConceptScore W2107834145C142724271 @default.
• W2107834145 hasConceptScore W2107834145C156957248 @default.
• W2107834145 hasConceptScore W2107834145C2776967927 @default.

• next