FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107850807> ?p ?o ?g. }

• W2107850807 endingPage "2215" @default.
• W2107850807 startingPage "2209" @default.
• W2107850807 abstract "Arachidonic acid (AA) metabolites from 15-lipoxygenase-1 (15-LO-1), trihydroxyeicosatrienoic acid (THETA), and hydroxyepoxyeicosatrienoic acid (HEETA) relax arteries. We studied 15-LO-1 expression, THETA and HEETA synthesis, and their effect on arterial relaxations and blood pressure in hypercholesterolemic nonatherosclerotic rabbits.Immunoblots, RTPCR analysis, and (14)C-AA metabolism revealed that hypercholesterolemia increased 15-LO-1 expression in the endothelium and THETA and HEETA synthesis in the arteries. Isometric tension recording, in presence of nitric oxide synthase (NOS) and cyclooxygenase (COX) inhibitors, showed greater relaxations to acetylcholine (ACH) and AA (max 76.0+/-4.6% and 79.5+/-2.4%, respectively) in aortas from hypercholesterolemic rabbits compared with normal rabbits (max 39.1+/-2.8% and 39.9+/-2.2%, respectively). AA induced greater hyperpolarization in the smooth muscle cells of hypercholesterolemic aortas (-45.85+/-3.0 mV) compared with normal aortas (-31.45+/-1.9 mV). The ACH- and AA-relaxations were inhibited by 15-LO-1 inhibitors. ACH induced hypotensive responses were greater in hypercholesterolemic rabbits in absence (-54.9+/-3.3%) or presence (-48.5+/-3.2%) of NOS and COX-inhibitors compared with control rabbits (-31.6+/-3.3% and -24.3+/-1.6%, respectively). BW755C reduced these responses in hypercholesterolemic rabbits to -29.3+/-2.3%.Hypercholesterolemia increases endothelial 15-LO-1 expression, THETA and HEETA synthesis and enhances vasorelaxation." @default.
• W2107850807 created "2016-06-24" @default.
• W2107850807 creator A5014603417 @default.
• W2107850807 creator A5034380368 @default.
• W2107850807 creator A5067916190 @default.
• W2107850807 date "2008-12-01" @default.
• W2107850807 modified "2023-09-27" @default.
• W2107850807 title "Hypercholesterolemia Enhances 15-Lipoxygenase–Mediated Vasorelaxation and Acetylcholine-Induced Hypotension" @default.
• W2107850807 cites W1934395836 @default.
• W2107850807 cites W1967892343 @default.
• W2107850807 cites W2016369481 @default.
• W2107850807 cites W2022439153 @default.
• W2107850807 cites W2044570760 @default.
• W2107850807 cites W2050062329 @default.
• W2107850807 cites W2053507136 @default.
• W2107850807 cites W2055586241 @default.
• W2107850807 cites W2072045984 @default.
• W2107850807 cites W2074920579 @default.
• W2107850807 cites W2082909259 @default.
• W2107850807 cites W2112437527 @default.
• W2107850807 cites W2114450979 @default.
• W2107850807 cites W2125347929 @default.
• W2107850807 cites W2144198424 @default.
• W2107850807 cites W2152874657 @default.
• W2107850807 cites W2154046244 @default.
• W2107850807 cites W2161953383 @default.
• W2107850807 cites W2170554836 @default.
• W2107850807 cites W2333891951 @default.
• W2107850807 doi "https://doi.org/10.1161/atvbaha.108.177113" @default.
• W2107850807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18832753" @default.
• W2107850807 hasPublicationYear "2008" @default.
• W2107850807 type Work @default.
• W2107850807 sameAs 2107850807 @default.
• W2107850807 citedByCount "15" @default.
• W2107850807 countsByYear W21078508072012 @default.
• W2107850807 countsByYear W21078508072013 @default.
• W2107850807 countsByYear W21078508072014 @default.
• W2107850807 countsByYear W21078508072015 @default.
• W2107850807 countsByYear W21078508072016 @default.
• W2107850807 crossrefType "journal-article" @default.
• W2107850807 hasAuthorship W2107850807A5014603417 @default.
• W2107850807 hasAuthorship W2107850807A5034380368 @default.
• W2107850807 hasAuthorship W2107850807A5067916190 @default.
• W2107850807 hasBestOaLocation W21078508071 @default.
• W2107850807 hasConcept C103486182 @default.
• W2107850807 hasConcept C120770815 @default.
• W2107850807 hasConcept C126322002 @default.
• W2107850807 hasConcept C134018914 @default.
• W2107850807 hasConcept C170493617 @default.
• W2107850807 hasConcept C181199279 @default.
• W2107850807 hasConcept C185592680 @default.
• W2107850807 hasConcept C2775910092 @default.
• W2107850807 hasConcept C2776889390 @default.
• W2107850807 hasConcept C2777622882 @default.
• W2107850807 hasConcept C2778078955 @default.
• W2107850807 hasConcept C2778938600 @default.
• W2107850807 hasConcept C2779395532 @default.
• W2107850807 hasConcept C2779689624 @default.
• W2107850807 hasConcept C2780561956 @default.
• W2107850807 hasConcept C2780857362 @default.
• W2107850807 hasConcept C2992686903 @default.
• W2107850807 hasConcept C519581460 @default.
• W2107850807 hasConcept C55493867 @default.
• W2107850807 hasConcept C71924100 @default.
• W2107850807 hasConceptScore W2107850807C103486182 @default.
• W2107850807 hasConceptScore W2107850807C120770815 @default.
• W2107850807 hasConceptScore W2107850807C126322002 @default.
• W2107850807 hasConceptScore W2107850807C134018914 @default.
• W2107850807 hasConceptScore W2107850807C170493617 @default.
• W2107850807 hasConceptScore W2107850807C181199279 @default.
• W2107850807 hasConceptScore W2107850807C185592680 @default.
• W2107850807 hasConceptScore W2107850807C2775910092 @default.
• W2107850807 hasConceptScore W2107850807C2776889390 @default.
• W2107850807 hasConceptScore W2107850807C2777622882 @default.
• W2107850807 hasConceptScore W2107850807C2778078955 @default.
• W2107850807 hasConceptScore W2107850807C2778938600 @default.
• W2107850807 hasConceptScore W2107850807C2779395532 @default.
• W2107850807 hasConceptScore W2107850807C2779689624 @default.
• W2107850807 hasConceptScore W2107850807C2780561956 @default.
• W2107850807 hasConceptScore W2107850807C2780857362 @default.
• W2107850807 hasConceptScore W2107850807C2992686903 @default.
• W2107850807 hasConceptScore W2107850807C519581460 @default.
• W2107850807 hasConceptScore W2107850807C55493867 @default.
• W2107850807 hasConceptScore W2107850807C71924100 @default.
• W2107850807 hasIssue "12" @default.
• W2107850807 hasLocation W21078508071 @default.
• W2107850807 hasLocation W21078508072 @default.
• W2107850807 hasOpenAccess W2107850807 @default.
• W2107850807 hasPrimaryLocation W21078508071 @default.
• W2107850807 hasRelatedWork W1979118653 @default.
• W2107850807 hasRelatedWork W1981662210 @default.
• W2107850807 hasRelatedWork W1996615419 @default.
• W2107850807 hasRelatedWork W2001649318 @default.
• W2107850807 hasRelatedWork W2038851254 @default.
• W2107850807 hasRelatedWork W2090805356 @default.
• W2107850807 hasRelatedWork W2107850807 @default.
• W2107850807 hasRelatedWork W2123805023 @default.
• W2107850807 hasRelatedWork W2131861405 @default.

• next