Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107853929> ?p ?o ?g. }
- W2107853929 endingPage "1326" @default.
- W2107853929 startingPage "1317" @default.
- W2107853929 abstract "Protein aggregation is associated with a variety of pathological conditions, including Alzheimer's and Creutzfeldt-Jakob diseases and type II diabetes. Such degenerative disorders result from the conversion of the normal soluble state of specific proteins into aggregated states that can ultimately form the characteristic amyloid fibrils found in diseased tissue. Under appropriate conditions it appears that many, perhaps all, proteins can be converted in vitro into amyloid fibrils. The aggregation propensities of different polypeptide chains have, however, been observed to vary substantially. Here, we describe an approach that uses the knowledge of the amino acid sequence and of the experimental conditions to reproduce, with a correlation coefficient of 0.92 and over five orders of magnitude, the in vitro aggregation rates of a wide range of unstructured peptides and proteins. These results indicate that the formation of protein aggregates can be rationalised to a considerable extent in terms of simple physico-chemical parameters that describe the properties of polypeptide chains and their environment." @default.
- W2107853929 created "2016-06-24" @default.
- W2107853929 creator A5026973541 @default.
- W2107853929 creator A5027682872 @default.
- W2107853929 creator A5032721511 @default.
- W2107853929 creator A5048683941 @default.
- W2107853929 creator A5091898546 @default.
- W2107853929 date "2004-08-01" @default.
- W2107853929 modified "2023-10-14" @default.
- W2107853929 title "Prediction of the Absolute Aggregation Rates of Amyloidogenic Polypeptide Chains" @default.
- W2107853929 cites W1963523582 @default.
- W2107853929 cites W1963994022 @default.
- W2107853929 cites W1967733770 @default.
- W2107853929 cites W1967773653 @default.
- W2107853929 cites W1968280815 @default.
- W2107853929 cites W1970213601 @default.
- W2107853929 cites W1970460403 @default.
- W2107853929 cites W1974288679 @default.
- W2107853929 cites W1975904672 @default.
- W2107853929 cites W1978672495 @default.
- W2107853929 cites W1979509752 @default.
- W2107853929 cites W1980125299 @default.
- W2107853929 cites W1990592765 @default.
- W2107853929 cites W1991210194 @default.
- W2107853929 cites W1991349307 @default.
- W2107853929 cites W1992684041 @default.
- W2107853929 cites W1993811485 @default.
- W2107853929 cites W1997369314 @default.
- W2107853929 cites W2005946684 @default.
- W2107853929 cites W2010212854 @default.
- W2107853929 cites W20120559 @default.
- W2107853929 cites W2012455318 @default.
- W2107853929 cites W2012561243 @default.
- W2107853929 cites W2014059004 @default.
- W2107853929 cites W2018633688 @default.
- W2107853929 cites W2018769240 @default.
- W2107853929 cites W2024895112 @default.
- W2107853929 cites W2033876560 @default.
- W2107853929 cites W2039397725 @default.
- W2107853929 cites W2044597283 @default.
- W2107853929 cites W2046127729 @default.
- W2107853929 cites W2048125591 @default.
- W2107853929 cites W2052417023 @default.
- W2107853929 cites W2053702506 @default.
- W2107853929 cites W2055378374 @default.
- W2107853929 cites W2055680113 @default.
- W2107853929 cites W2056776699 @default.
- W2107853929 cites W2060526494 @default.
- W2107853929 cites W2060723204 @default.
- W2107853929 cites W2062397185 @default.
- W2107853929 cites W2063937171 @default.
- W2107853929 cites W2064677495 @default.
- W2107853929 cites W2075086095 @default.
- W2107853929 cites W2076834744 @default.
- W2107853929 cites W2077463136 @default.
- W2107853929 cites W2079893739 @default.
- W2107853929 cites W2080908359 @default.
- W2107853929 cites W2081998222 @default.
- W2107853929 cites W2085899859 @default.
- W2107853929 cites W2090235059 @default.
- W2107853929 cites W2092625134 @default.
- W2107853929 cites W2094587801 @default.
- W2107853929 cites W2096601751 @default.
- W2107853929 cites W2101579398 @default.
- W2107853929 cites W2110476236 @default.
- W2107853929 cites W2118038132 @default.
- W2107853929 cites W2119152368 @default.
- W2107853929 cites W2120717592 @default.
- W2107853929 cites W2130663065 @default.
- W2107853929 cites W2135007733 @default.
- W2107853929 cites W2136355739 @default.
- W2107853929 cites W2145904082 @default.
- W2107853929 cites W2153439292 @default.
- W2107853929 cites W2157842863 @default.
- W2107853929 cites W2167587239 @default.
- W2107853929 cites W2168334242 @default.
- W2107853929 cites W2749203687 @default.
- W2107853929 cites W4241797254 @default.
- W2107853929 cites W4243894108 @default.
- W2107853929 cites W4244624346 @default.
- W2107853929 doi "https://doi.org/10.1016/j.jmb.2004.06.043" @default.
- W2107853929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15302561" @default.
- W2107853929 hasPublicationYear "2004" @default.
- W2107853929 type Work @default.
- W2107853929 sameAs 2107853929 @default.
- W2107853929 citedByCount "295" @default.
- W2107853929 countsByYear W21078539292012 @default.
- W2107853929 countsByYear W21078539292013 @default.
- W2107853929 countsByYear W21078539292014 @default.
- W2107853929 countsByYear W21078539292015 @default.
- W2107853929 countsByYear W21078539292016 @default.
- W2107853929 countsByYear W21078539292017 @default.
- W2107853929 countsByYear W21078539292018 @default.
- W2107853929 countsByYear W21078539292019 @default.
- W2107853929 countsByYear W21078539292020 @default.
- W2107853929 countsByYear W21078539292021 @default.
- W2107853929 countsByYear W21078539292022 @default.
- W2107853929 countsByYear W21078539292023 @default.