Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107856368> ?p ?o ?g. }
- W2107856368 endingPage "617" @default.
- W2107856368 startingPage "606" @default.
- W2107856368 abstract "We previously observed that the human bitter taste receptor T2R38 is an important component of upper respiratory innate defense because it detects acyl homoserine lactone (AHL) quorum-sensing molecules secreted by Gram-negative bacteria. T2R38 activation in human sinonasal epithelial cells stimulates calcium and NO signals that increase mucociliary clearance, the major physical respiratory defense against inhaled pathogens. While mice do not have a clear T2R38 ortholog, they do have bitter taste receptors capable of responding to T2R38 agonists, suggesting that T2R-mediated innate immune mechanisms may be conserved in mice. We examined whether AHLs activate calcium and NO signaling in mouse nasal epithelial cells, and utilized pharmacology, as well as cells from knockout mice lacking important components of canonical taste signal transduction pathways, to determine if AHL-stimulated responses require taste signaling molecules. We found that AHLs stimulate calcium-dependent NO production that increases mucociliary clearance and thus likely serves an innate immune role against Gram-negative bacteria. These responses require PLCβ2 and TRPM5 taste signaling components, but not α-gustducin. These data suggest the mouse may be a useful model for further studies of T2R-mediated innate immunity." @default.
- W2107856368 created "2016-06-24" @default.
- W2107856368 creator A5040022220 @default.
- W2107856368 creator A5053465320 @default.
- W2107856368 creator A5059229948 @default.
- W2107856368 creator A5077476688 @default.
- W2107856368 creator A5078854539 @default.
- W2107856368 date "2013-09-17" @default.
- W2107856368 modified "2023-10-05" @default.
- W2107856368 title "Mouse nasal epithelial innate immune responses to <i>Pseudomonas aeruginosa</i> quorum-sensing molecules require taste signaling components" @default.
- W2107856368 cites W115423185 @default.
- W2107856368 cites W1480928884 @default.
- W2107856368 cites W1540070193 @default.
- W2107856368 cites W1542303954 @default.
- W2107856368 cites W1793440766 @default.
- W2107856368 cites W1903990541 @default.
- W2107856368 cites W1963718985 @default.
- W2107856368 cites W1969104991 @default.
- W2107856368 cites W1969410487 @default.
- W2107856368 cites W1971543781 @default.
- W2107856368 cites W1971560305 @default.
- W2107856368 cites W197627183 @default.
- W2107856368 cites W1983108533 @default.
- W2107856368 cites W1985101496 @default.
- W2107856368 cites W1985524805 @default.
- W2107856368 cites W1987703588 @default.
- W2107856368 cites W1990205700 @default.
- W2107856368 cites W1999355550 @default.
- W2107856368 cites W2002676268 @default.
- W2107856368 cites W2006829169 @default.
- W2107856368 cites W2007332360 @default.
- W2107856368 cites W2014488464 @default.
- W2107856368 cites W2016158447 @default.
- W2107856368 cites W2016948259 @default.
- W2107856368 cites W2019491742 @default.
- W2107856368 cites W2020431943 @default.
- W2107856368 cites W2023102785 @default.
- W2107856368 cites W2024113375 @default.
- W2107856368 cites W2027635017 @default.
- W2107856368 cites W2030769846 @default.
- W2107856368 cites W2031815558 @default.
- W2107856368 cites W2035040196 @default.
- W2107856368 cites W2035314011 @default.
- W2107856368 cites W2036192318 @default.
- W2107856368 cites W2048849077 @default.
- W2107856368 cites W2054237603 @default.
- W2107856368 cites W2057327815 @default.
- W2107856368 cites W2057361211 @default.
- W2107856368 cites W2065443731 @default.
- W2107856368 cites W2066520363 @default.
- W2107856368 cites W2069066295 @default.
- W2107856368 cites W2070656125 @default.
- W2107856368 cites W2072334346 @default.
- W2107856368 cites W2074779228 @default.
- W2107856368 cites W2078193241 @default.
- W2107856368 cites W2079858948 @default.
- W2107856368 cites W2081020551 @default.
- W2107856368 cites W2081485204 @default.
- W2107856368 cites W2082692901 @default.
- W2107856368 cites W2083399112 @default.
- W2107856368 cites W2086096457 @default.
- W2107856368 cites W2086498492 @default.
- W2107856368 cites W2089727972 @default.
- W2107856368 cites W2103465415 @default.
- W2107856368 cites W2103722201 @default.
- W2107856368 cites W2113624371 @default.
- W2107856368 cites W2117606696 @default.
- W2107856368 cites W2119517589 @default.
- W2107856368 cites W2121251468 @default.
- W2107856368 cites W2123318097 @default.
- W2107856368 cites W2131284004 @default.
- W2107856368 cites W2137263528 @default.
- W2107856368 cites W2137311570 @default.
- W2107856368 cites W2138249804 @default.
- W2107856368 cites W2139177655 @default.
- W2107856368 cites W2142510517 @default.
- W2107856368 cites W2142520192 @default.
- W2107856368 cites W2144827439 @default.
- W2107856368 cites W2149760554 @default.
- W2107856368 cites W2150028083 @default.
- W2107856368 cites W2157649826 @default.
- W2107856368 cites W2159711449 @default.
- W2107856368 cites W2161442735 @default.
- W2107856368 cites W2165664061 @default.
- W2107856368 cites W2166662833 @default.
- W2107856368 cites W2167483247 @default.
- W2107856368 cites W2168671905 @default.
- W2107856368 cites W2170342544 @default.
- W2107856368 cites W2312399784 @default.
- W2107856368 cites W2406591348 @default.
- W2107856368 doi "https://doi.org/10.1177/1753425913503386" @default.
- W2107856368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4811369" @default.
- W2107856368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24045336" @default.
- W2107856368 hasPublicationYear "2013" @default.
- W2107856368 type Work @default.
- W2107856368 sameAs 2107856368 @default.
- W2107856368 citedByCount "85" @default.
- W2107856368 countsByYear W21078563682014 @default.