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• W2107859939 abstract "Ku80 facilitates DNA repair and therefore should suppress cancer. However, ku80(-/-) mice exhibit reduced cancer, although they age prematurely and have a shortened life span. We tested the hypothesis that Ku80 deletion suppresses cancer by enhancing cellular tumor-suppressive responses to inefficiently repaired DNA damage. In support of this hypothesis, Ku80 deletion ameliorated tumor burden in APC(MIN) mice and increased a p53-mediated DNA damage response, DNA lesions, and chromosomal rearrangements. Thus, contrary to its assumed role as a caretaker tumor suppressor, Ku80 facilitates tumor growth most likely by dampening baseline cellular DNA damage responses." @default.
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• W2107859939 date "2008-11-14" @default.
• W2107859939 modified "2023-09-23" @default.
• W2107859939 title "Ku80 Deletion Suppresses Spontaneous Tumors and Induces a p53-Mediated DNA Damage Response" @default.
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• W2107859939 doi "https://doi.org/10.1158/0008-5472.can-08-2085" @default.
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