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• W2107888520 endingPage "2395" @default.
• W2107888520 startingPage "2383" @default.
• W2107888520 abstract "In plants, animals, and fungi, DNA methylation is frequently associated with gene silencing, yet little is known about the role of the methylation in silencing. In Neurospora crassa, repeated sequences are silenced by repeat-induced point mutation (RIP) and genes that have suffered numerous GC --> AT mutations by RIP are typically methylated at remaining cytosines. We investigated possible effects on transcription from methylation associated with RIP by taking advantage of 5-azacytidine, which prevents most methylation in Neurospora and a dim-2 mutation that abolishes all detectable methylation. Northern analyses revealed that methylation prevents the accumulation of transcripts from genes mutated by RIP. Measurements of transcription rates in vivo showed that methylation inhibits transcription severely but does not influence mRNA stability. Results of nuclear run-on experiments demonstrated that transcription initiation was not significantly inhibited by the dense methylation in the promoter sequences. In contrast, methylation blocked transcription elongation in vivo." @default.
• W2107888520 created "2016-06-24" @default.
• W2107888520 creator A5034497861 @default.
• W2107888520 creator A5056584197 @default.
• W2107888520 date "1997-09-15" @default.
• W2107888520 modified "2023-09-27" @default.
• W2107888520 title "DNA methylation inhibits elongation but not initiation of transcription in <i>Neurospora crassa</i>" @default.
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• W2107888520 doi "https://doi.org/10.1101/gad.11.18.2383" @default.
• W2107888520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316521" @default.
• W2107888520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9308966" @default.
• W2107888520 hasPublicationYear "1997" @default.
• W2107888520 type Work @default.

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