FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107890342> ?p ?o ?g. }

• W2107890342 endingPage "191" @default.
• W2107890342 startingPage "185" @default.
• W2107890342 abstract "It is known that cisplatin (CDDP) potentiates the cytotoxicity of 5-fluorouracil (5-FU), and that the biochemical mechanism is an increase in the intracellular reduced folate levels in the tumor cells. We investigated the effect of consecutive administration with lower-dose CDDP on intracellular accumulation of reduced folate and the activity of methionine synthase, a key enzyme in intracellular methionine synthesis. When CDDP (1 mg/kg) was administered i.p. to ascitic Yoshida sarcoma-bearing rats for 4 consecutive days, both the reduced folate levels and methionine synthase activity in the cells significantly increased, as the same as a single 5 mg/kg dose of CDDP. Furthermore, when Yoshida sarcoma-bearing rats were pre-treated with 1 mg/kg CDDP for 5 consecutive days, [14C]L-methionine incorporation into the isolated ascitic cells was significantly inhibited as compared to that in non-treated cells, suggesting that consecutive administration of lower-dose CDDP is capable of inducing the intracellular modulation of reduced folate levels and methionine synthase activity via inhibition of cellular uptake of methionine. In addition, 5-day administration of lower-dose (1 mg/kg) CDDP potentiated the antitumor effect of 5 mg/kg S-1, a new oral preparation of tegafur, given for 7 consecutive days, and this combined effect was almost similar to the antitumor effect of a combination of S-1 and a single conventional dose (5 mg/kg) of CDDP. Consecutive lower-dose CDDP also may be concluded to act as an important modulator of the enhancement of 5-FU cytotoxicity in experimental tumors." @default.
• W2107890342 created "2016-06-24" @default.
• W2107890342 creator A5029970515 @default.
• W2107890342 creator A5044552280 @default.
• W2107890342 creator A5057051718 @default.
• W2107890342 creator A5071192697 @default.
• W2107890342 date "2000-11-01" @default.
• W2107890342 modified "2023-09-23" @default.
• W2107890342 title "Effect of consecutive lower-dose cisplatin in enhancement of 5-fluorouracil cytotoxicity in experimental tumor cells in vivo" @default.
• W2107890342 cites W109577459 @default.
• W2107890342 cites W1902766545 @default.
• W2107890342 cites W1972380358 @default.
• W2107890342 cites W1981133180 @default.
• W2107890342 cites W1986634144 @default.
• W2107890342 cites W1989751695 @default.
• W2107890342 cites W2010416533 @default.
• W2107890342 cites W2017800701 @default.
• W2107890342 cites W2018619890 @default.
• W2107890342 cites W2027678619 @default.
• W2107890342 cites W2036409540 @default.
• W2107890342 cites W2044228838 @default.
• W2107890342 cites W2046102541 @default.
• W2107890342 cites W2047862714 @default.
• W2107890342 cites W2057902898 @default.
• W2107890342 cites W2066312401 @default.
• W2107890342 cites W2074659347 @default.
• W2107890342 cites W2077902459 @default.
• W2107890342 cites W2146505874 @default.
• W2107890342 cites W2167282749 @default.
• W2107890342 cites W2318507318 @default.
• W2107890342 cites W2382689855 @default.
• W2107890342 cites W4239514162 @default.
• W2107890342 doi "https://doi.org/10.1016/s0304-3835(00)00583-8" @default.
• W2107890342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11053648" @default.
• W2107890342 hasPublicationYear "2000" @default.
• W2107890342 type Work @default.
• W2107890342 sameAs 2107890342 @default.
• W2107890342 citedByCount "23" @default.
• W2107890342 countsByYear W21078903422012 @default.
• W2107890342 countsByYear W21078903422013 @default.
• W2107890342 countsByYear W21078903422016 @default.
• W2107890342 countsByYear W21078903422019 @default.
• W2107890342 crossrefType "journal-article" @default.
• W2107890342 hasAuthorship W2107890342A5029970515 @default.
• W2107890342 hasAuthorship W2107890342A5044552280 @default.
• W2107890342 hasAuthorship W2107890342A5057051718 @default.
• W2107890342 hasAuthorship W2107890342A5071192697 @default.
• W2107890342 hasConcept C109316439 @default.
• W2107890342 hasConcept C123321153 @default.
• W2107890342 hasConcept C126322002 @default.
• W2107890342 hasConcept C150903083 @default.
• W2107890342 hasConcept C185592680 @default.
• W2107890342 hasConcept C202751555 @default.
• W2107890342 hasConcept C207001950 @default.
• W2107890342 hasConcept C2776694085 @default.
• W2107890342 hasConcept C2778239845 @default.
• W2107890342 hasConcept C2780456651 @default.
• W2107890342 hasConcept C2780912031 @default.
• W2107890342 hasConcept C515207424 @default.
• W2107890342 hasConcept C55493867 @default.
• W2107890342 hasConcept C71924100 @default.
• W2107890342 hasConcept C79879829 @default.
• W2107890342 hasConcept C86803240 @default.
• W2107890342 hasConcept C98274493 @default.
• W2107890342 hasConceptScore W2107890342C109316439 @default.
• W2107890342 hasConceptScore W2107890342C123321153 @default.
• W2107890342 hasConceptScore W2107890342C126322002 @default.
• W2107890342 hasConceptScore W2107890342C150903083 @default.
• W2107890342 hasConceptScore W2107890342C185592680 @default.
• W2107890342 hasConceptScore W2107890342C202751555 @default.
• W2107890342 hasConceptScore W2107890342C207001950 @default.
• W2107890342 hasConceptScore W2107890342C2776694085 @default.
• W2107890342 hasConceptScore W2107890342C2778239845 @default.
• W2107890342 hasConceptScore W2107890342C2780456651 @default.
• W2107890342 hasConceptScore W2107890342C2780912031 @default.
• W2107890342 hasConceptScore W2107890342C515207424 @default.
• W2107890342 hasConceptScore W2107890342C55493867 @default.
• W2107890342 hasConceptScore W2107890342C71924100 @default.
• W2107890342 hasConceptScore W2107890342C79879829 @default.
• W2107890342 hasConceptScore W2107890342C86803240 @default.
• W2107890342 hasConceptScore W2107890342C98274493 @default.
• W2107890342 hasIssue "2" @default.
• W2107890342 hasLocation W21078903421 @default.
• W2107890342 hasLocation W21078903422 @default.
• W2107890342 hasOpenAccess W2107890342 @default.
• W2107890342 hasPrimaryLocation W21078903421 @default.
• W2107890342 hasRelatedWork W1583662802 @default.
• W2107890342 hasRelatedWork W2026635976 @default.
• W2107890342 hasRelatedWork W2036409540 @default.
• W2107890342 hasRelatedWork W2049758628 @default.
• W2107890342 hasRelatedWork W2379292808 @default.
• W2107890342 hasRelatedWork W2407812582 @default.
• W2107890342 hasRelatedWork W2416964709 @default.
• W2107890342 hasRelatedWork W2517050254 @default.
• W2107890342 hasRelatedWork W3165143150 @default.
• W2107890342 hasRelatedWork W91155106 @default.
• W2107890342 hasVolume "160" @default.
• W2107890342 isParatext "false" @default.

• next