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- W2107897112 abstract "Conflict of interest: none declared. Antihistamines are widely used by dermatologists to help control the symptoms of a range of pruritic conditions, but also specifically for the treatment of urticaria and other mast cell‐driven disorders. These drugs are considered safe, with few serious side‐effects, so routine monitoring is rarely performed. We report the case of a patient with acute interstitial nephritis (AIN) associated with the antihistamine cetirizine. A 63‐year‐old man presented with a 9‐month history of lethargy, thirst and nocturia. The patient had a 22‐year history of urticaria pigmentosa, and had received courses of narrowband (TL‐01) phototherapy. He had been taking cetirizine 10 mg daily for 5 years. Laboratory investigations showed that the patient had raised urea (18.5 mmol/L; normal range 2.5–7.5 mmol/L) and creatinine (389 μmol/L; 60–110 μmol/L). Results of renal ultrasonography were within normal limits. On histological examination of a renal biopsy, a heavy lymphocytic and plasma cell infiltrate was seen within the interstitium, with occasional eosinophils. Granulomas formed of clustered histiocytes were also present (Fig. 1a,b)." @default.
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- W2107897112 date "2012-10-22" @default.
- W2107897112 modified "2023-09-27" @default.
- W2107897112 title "Acute interstitial nephritis secondary to long-term use of cetirizine for the treatment of urticaria pigmentosa" @default.
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- W2107897112 doi "https://doi.org/10.1111/j.1365-2230.2012.04471.x" @default.
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