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• W2107901901 abstract "Inactivation of the gene encoding the periplasmic protease DegP confers a high-temperature-sensitive phenotype in Escherichia coli. We have previously demonstrated that a degP mutant of E. coli strain CBM (W3110 pldA1) is not temperature sensitive and showed that this was most likely due to constitutive activation of the sigma E and Cpx extracytoplasmic stress regulons in the parent strain. In this study, further characterization of this strain revealed a previously unknown cryptic mutation that rescued the degP temperature-sensitive phenotype by inducing the extracytoplasmic stress regulons. We identified the cryptic mutation as an 11-bp deletion of nucleotides 1884 to 1894 of the adenylate cyclase-encoding cyaA gene (cyaAdelta11). The mechanism in which cyaAdelta11 induces the sigma E and Cpx regulons involves decreased activity of the mutant adenylate cyclase. Addition of exogenous cyclic AMP (cAMP) to the growth medium of a cyaAdelta11 mutant strain that contains a Cpx- and sigma E-inducible degP-lacZ reporter fusion decreased beta-galactosidase expression to levels observed in a cyaA+ strain. We also found that a cyaA null mutant displayed even higher levels of extracytoplasmic stress regulon activation compared to a cyaAdelta11 mutant. Thus, we conclude that the lowered concentration of cAMP in cyaA mutants induces both sigma E and Cpx extracytoplasmic stress regulons and thereby rescues the degP temperature-sensitive phenotype." @default.
• W2107901901 created "2016-06-24" @default.
• W2107901901 creator A5020743689 @default.
• W2107901901 creator A5078244906 @default.
• W2107901901 creator A5079376254 @default.
• W2107901901 date "2005-09-15" @default.
• W2107901901 modified "2023-10-14" @default.
• W2107901901 title "Adenylate Cyclase Mutations Rescue the degP Temperature-Sensitive Phenotype and Induce the Sigma E and Cpx Extracytoplasmic Stress Regulons in Escherichia coli" @default.
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• W2107901901 doi "https://doi.org/10.1128/jb.187.18.6309-6316.2005" @default.
• W2107901901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1236634" @default.
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