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- W2107919710 abstract "Alpha-2 noradrenergic agonists may have wide applicability in the treatment of pre-frontal cortex deficits in primates and behavioral dysfunction in man. We have undertaken this study to determine the effect of an alpha-2 agonist, guanfacine, on regional cerebral blood flow (rCBF) in humans. Three subject groups were evaluated: normal controls, subjects with frontal lobe epilepsy (FLE), and subjects with temporal lobe epilepsy (TLE). All underwent a number of PET scans using 15O-water, with half before and half after a single dose of guanfacine. A wide area of increased rCBF was seen in the frontal lobe, maximal at the central region, following guanfacine in controls and subjects with TLE. Smaller areas of decrease in rCBF were seen in the posterior temporal-occipital cortex. In the FLE group a decrease in rCBF was seen in the dorsal prefrontal cortex on the epileptogenic side with only small increases seen in the mid- to anterior temporal perisylvian areas. The ability of alpha-2 agonists to enhance performance of tasks reliant on prefrontal cortex, without improving tasks believed to rely on intact temporal-hippocampal function, may be explained by these results. Epileptogenic zones appear to create both direct and indirect changes in patterns of drug response. Further studies on the cognitive properties of these agents in humans should be encouraged." @default.
- W2107919710 created "2016-06-24" @default.
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- W2107919710 date "2000-09-01" @default.
- W2107919710 modified "2023-10-15" @default.
- W2107919710 title "The Effects of an Alpha-2 Adrenergic Agonist, Guanfacine, on rCBF in Human Cortex in Normal Controls and Subjects with Focal Epilepsy" @default.
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- W2107919710 cites W1970116189 @default.
- W2107919710 cites W1973627502 @default.
- W2107919710 cites W1979428849 @default.
- W2107919710 cites W1982166376 @default.
- W2107919710 cites W1987445320 @default.
- W2107919710 cites W1990005524 @default.
- W2107919710 cites W1994357188 @default.
- W2107919710 cites W1994625228 @default.
- W2107919710 cites W1999045454 @default.
- W2107919710 cites W2000247756 @default.
- W2107919710 cites W2000735704 @default.
- W2107919710 cites W2005789597 @default.
- W2107919710 cites W2008632370 @default.
- W2107919710 cites W2009135374 @default.
- W2107919710 cites W2011140844 @default.
- W2107919710 cites W2011216865 @default.
- W2107919710 cites W2017938550 @default.
- W2107919710 cites W2026265341 @default.
- W2107919710 cites W2027535369 @default.
- W2107919710 cites W2032517670 @default.
- W2107919710 cites W2032807853 @default.
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- W2107919710 cites W2033787640 @default.
- W2107919710 cites W2034577726 @default.
- W2107919710 cites W2034867088 @default.
- W2107919710 cites W2035183926 @default.
- W2107919710 cites W2035947853 @default.
- W2107919710 cites W2039755273 @default.
- W2107919710 cites W2041343218 @default.
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- W2107919710 cites W2042535040 @default.
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- W2107919710 cites W2050551646 @default.
- W2107919710 cites W2051883007 @default.
- W2107919710 cites W2053758131 @default.
- W2107919710 cites W2054430521 @default.
- W2107919710 cites W2056278614 @default.
- W2107919710 cites W2057821209 @default.
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- W2107919710 doi "https://doi.org/10.1016/s0893-133x(00)00101-9" @default.
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