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- W2107950861 abstract "Golgi antiapoptotic proteins (GAAPs) are highly conserved Golgi membrane proteins that inhibit apoptosis and promote Ca2+ release from intracellular stores. Given the role of Ca2+ in controlling cell adhesion and motility, we hypothesized that human GAAP (hGAAP) might influence these events. In this paper, we present evidence that hGAAP increased cell adhesion, spreading, and migration in a manner that depended on the C-terminal domain of hGAAP. We show that hGAAP increased store-operated Ca2+ entry and thereby the activity of calpain at newly forming protrusions. These hGAAP-dependent effects regulated focal adhesion dynamics and cell migration. Indeed, inhibition or knockdown of calpain 2 abrogated the effects of hGAAP on cell spreading and migration. Our data reveal that hGAAP is a novel regulator of focal adhesion dynamics, cell adhesion, and migration by controlling localized Ca2+-dependent activation of calpain." @default.
- W2107950861 created "2016-06-24" @default.
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- W2107950861 date "2013-08-12" @default.
- W2107950861 modified "2023-10-15" @default.
- W2107950861 title "hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2" @default.
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- W2107950861 doi "https://doi.org/10.1083/jcb.201301016" @default.
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