FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107966379> ?p ?o ?g. }

• W2107966379 endingPage "600" @default.
• W2107966379 startingPage "575" @default.
• W2107966379 abstract "Carbonic anhydrases (CAs, EC 4.2.1.1) are wide-spread zinc enzymes, present in archaeo- and eubacteria, algae, green plants and animals. Within these organisms CAs are encoded by three distinct, evolutionarily unrelated gene families: the α-CA, the β-CA and the γ-CA families, respectively. These enzymes are very efficient catalysts for the reversible hydration of CO2 to bicarbonate; the α-CAs possess high versatility, being able to catalyse other hydrolytic processes. It is not known whether other reactions catalysed by CAs (than the hydration of CO2/dehydration of HCO-) may have physiological relevance in systems where these enzymes are present. CAs are inhibited primarily by two main classes of compounds: the metal complexing inorganic anions (e.g., cyanide, cyanate, thiocyanate, azide, hydrogensulphide etc.) and the unsubstituted sulphonamides possessing the general formula RSO2NH2 (R = aryl; hetaryl; perhaloalkyl). The first type of inhibitor was important for understanding in detail the catalytic and inhibitory mechanisms, whereas the second led to the development of several classes of pharmacological agents. Inhibitors of both types directly bind to the metal ion within the enzyme active site, either by substituting the zinc-bound H-, or adding to the co-ordination sphere, leading thus to pentaco-ordinated Zn(II). Sulphonamide CA inhibitors (CAIs) are useful as diuretics, or in the treatment and prevention of a variety of diseases such as glaucoma, epilepsy, congestive heart failure, mountain sickness, gastric and duodenal ulcers, neurological disorders and osteoporosis among others, as well as diagnostic tools. Their applications are due to the wide distribution of the different α-CA isozymes (14 are presently known) in higher vertebrates, where they play important physiological functions related to respiration and transport of CO2/HCO3 between metabolising tissues and the lungs, pH and CO2 homeostasis, electrolyte secretion in a variety of tissues/organs, and biosynthetic reactions, such as gluconeogenesis and ureagenesis, among others. CA activators have recently been described and their mechanism of action at molecular level elucidated. Such agents might be useful for developing therapies for the CA deficiency syndrome." @default.
• W2107966379 created "2016-06-24" @default.
• W2107966379 creator A5035652477 @default.
• W2107966379 creator A5086011099 @default.
• W2107966379 date "2000-05-01" @default.
• W2107966379 modified "2023-10-16" @default.
• W2107966379 title "Carbonic anhydrase inhibitors and their therapeutic potential" @default.
• W2107966379 cites W1549224984 @default.
• W2107966379 cites W1585936714 @default.
• W2107966379 cites W1654789532 @default.
• W2107966379 cites W174929306 @default.
• W2107966379 cites W1964570752 @default.
• W2107966379 cites W1966670719 @default.
• W2107966379 cites W1966953828 @default.
• W2107966379 cites W1969332772 @default.
• W2107966379 cites W1969526515 @default.
• W2107966379 cites W1969638732 @default.
• W2107966379 cites W1971832641 @default.
• W2107966379 cites W1971968210 @default.
• W2107966379 cites W1976495896 @default.
• W2107966379 cites W1979080059 @default.
• W2107966379 cites W1980648696 @default.
• W2107966379 cites W1990003852 @default.
• W2107966379 cites W1998427250 @default.
• W2107966379 cites W1998904001 @default.
• W2107966379 cites W2001157456 @default.
• W2107966379 cites W2001216966 @default.
• W2107966379 cites W2002584091 @default.
• W2107966379 cites W2005218170 @default.
• W2107966379 cites W2005676751 @default.
• W2107966379 cites W2006576609 @default.
• W2107966379 cites W2006618734 @default.
• W2107966379 cites W2008555596 @default.
• W2107966379 cites W2009466851 @default.
• W2107966379 cites W2010646982 @default.
• W2107966379 cites W2013734749 @default.
• W2107966379 cites W2017323569 @default.
• W2107966379 cites W2021359541 @default.
• W2107966379 cites W2025183758 @default.
• W2107966379 cites W2026411584 @default.
• W2107966379 cites W2027317338 @default.
• W2107966379 cites W2029444159 @default.
• W2107966379 cites W2029923009 @default.
• W2107966379 cites W2030710147 @default.
• W2107966379 cites W2032235584 @default.
• W2107966379 cites W2033007011 @default.
• W2107966379 cites W2034082998 @default.
• W2107966379 cites W2035762567 @default.
• W2107966379 cites W2044634803 @default.
• W2107966379 cites W2045049503 @default.
• W2107966379 cites W2049635047 @default.
• W2107966379 cites W2050046796 @default.
• W2107966379 cites W2054963396 @default.
• W2107966379 cites W2055190474 @default.
• W2107966379 cites W2059948875 @default.
• W2107966379 cites W2061028114 @default.
• W2107966379 cites W2072458613 @default.
• W2107966379 cites W2074341789 @default.
• W2107966379 cites W2078475461 @default.
• W2107966379 cites W2088858664 @default.
• W2107966379 cites W2089958765 @default.
• W2107966379 cites W2090056732 @default.
• W2107966379 cites W2090168211 @default.
• W2107966379 cites W2096467811 @default.
• W2107966379 cites W2106147477 @default.
• W2107966379 cites W2111008899 @default.
• W2107966379 cites W2115014360 @default.
• W2107966379 cites W2118262335 @default.
• W2107966379 cites W2125635028 @default.
• W2107966379 cites W2134353966 @default.
• W2107966379 cites W2141978210 @default.
• W2107966379 cites W2146370713 @default.
• W2107966379 cites W2156290068 @default.
• W2107966379 cites W2161820871 @default.
• W2107966379 cites W2165181270 @default.
• W2107966379 cites W2169773244 @default.
• W2107966379 cites W2170133841 @default.
• W2107966379 cites W2170446546 @default.
• W2107966379 cites W2170637723 @default.
• W2107966379 cites W2209091908 @default.
• W2107966379 cites W2313466306 @default.
• W2107966379 cites W2325996227 @default.
• W2107966379 cites W2332981069 @default.
• W2107966379 cites W2341251717 @default.
• W2107966379 cites W2410797461 @default.
• W2107966379 cites W4317564093 @default.
• W2107966379 doi "https://doi.org/10.1517/13543776.10.5.575" @default.
• W2107966379 hasPublicationYear "2000" @default.
• W2107966379 type Work @default.
• W2107966379 sameAs 2107966379 @default.
• W2107966379 citedByCount "477" @default.
• W2107966379 countsByYear W21079663792012 @default.
• W2107966379 countsByYear W21079663792013 @default.
• W2107966379 countsByYear W21079663792014 @default.
• W2107966379 countsByYear W21079663792015 @default.
• W2107966379 countsByYear W21079663792016 @default.
• W2107966379 countsByYear W21079663792017 @default.
• W2107966379 countsByYear W21079663792018 @default.

• next