FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107982423> ?p ?o ?g. }

• W2107982423 endingPage "85" @default.
• W2107982423 startingPage "76" @default.
• W2107982423 abstract "The usefulness of Docetaxel (DT) as an anti-cancer agent is limited to parenteral route owing to its very poor oral bioavailability. Thus, to improve its oral efficacy, DT was loaded in novel cationic lipid nanocapsules (DT CLNC). The DT CLNC possessed size of 130–150 nm, zeta potential of +72mV, adequate DT loading and over 95% encapsulation efficiency. TEM revealed capsular structure of DT CLNC. Lipolysis study indicated improved solubilization of DT by nanocapsules in comparison to DT solution. DT CLNC exhibited significantly higher release of DT in comparison to DT solution during in vitro permeation studies employing non-reverted rat-intestinal sac. Superior uptake of DT in zebra fishes exposed to DT CLNC resulted in greater apoptosis-based cell death as compared to those exposed to DT solution. This correlated well with the significantly superior (p < 0.05) anti-angiogenic activity of DT CLNC system over DT solution, in zebra fish model. DT CLNC also inhibited tumor growth in melanoma cell line induced tumors in C57BL/6 mice significantly, as compared to DT solution (p < 0.05). The DT CLNC system demonstrated adequate stability, with tremendous potential to improve oral efficacy of DT and can serve as an alternative to existing DT formulations available commercially for parenteral use." @default.
• W2107982423 created "2016-06-24" @default.
• W2107982423 creator A5016774685 @default.
• W2107982423 creator A5019283106 @default.
• W2107982423 creator A5019489319 @default.
• W2107982423 creator A5064519080 @default.
• W2107982423 creator A5076193656 @default.
• W2107982423 creator A5078158266 @default.
• W2107982423 creator A5079861531 @default.
• W2107982423 creator A5079881414 @default.
• W2107982423 date "2014-10-20" @default.
• W2107982423 modified "2023-10-18" @default.
• W2107982423 title "Docetaxel in cationic lipid nanocapsules for enhanced<i>in vivo</i>activity" @default.
• W2107982423 cites W1264540065 @default.
• W2107982423 cites W1649979258 @default.
• W2107982423 cites W1966595448 @default.
• W2107982423 cites W1968418753 @default.
• W2107982423 cites W1989619366 @default.
• W2107982423 cites W2006424018 @default.
• W2107982423 cites W2012471255 @default.
• W2107982423 cites W2016829041 @default.
• W2107982423 cites W2016971948 @default.
• W2107982423 cites W2036181656 @default.
• W2107982423 cites W2037069199 @default.
• W2107982423 cites W2039930136 @default.
• W2107982423 cites W2044578448 @default.
• W2107982423 cites W2047520487 @default.
• W2107982423 cites W2051759959 @default.
• W2107982423 cites W2054433499 @default.
• W2107982423 cites W2055576047 @default.
• W2107982423 cites W2062732827 @default.
• W2107982423 cites W2062955229 @default.
• W2107982423 cites W2068120671 @default.
• W2107982423 cites W2076022232 @default.
• W2107982423 cites W2084280975 @default.
• W2107982423 cites W2084535944 @default.
• W2107982423 cites W2088142318 @default.
• W2107982423 cites W2118650779 @default.
• W2107982423 cites W2127532332 @default.
• W2107982423 cites W2149429360 @default.
• W2107982423 cites W2149657563 @default.
• W2107982423 cites W2155315199 @default.
• W2107982423 cites W2155792695 @default.
• W2107982423 cites W2316119140 @default.
• W2107982423 cites W2325103687 @default.
• W2107982423 cites W2332285862 @default.
• W2107982423 doi "https://doi.org/10.3109/10837450.2014.971374" @default.
• W2107982423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25329444" @default.
• W2107982423 hasPublicationYear "2014" @default.
• W2107982423 type Work @default.
• W2107982423 sameAs 2107982423 @default.
• W2107982423 citedByCount "8" @default.
• W2107982423 countsByYear W21079824232016 @default.
• W2107982423 countsByYear W21079824232017 @default.
• W2107982423 countsByYear W21079824232019 @default.
• W2107982423 countsByYear W21079824232020 @default.
• W2107982423 crossrefType "journal-article" @default.
• W2107982423 hasAuthorship W2107982423A5016774685 @default.
• W2107982423 hasAuthorship W2107982423A5019283106 @default.
• W2107982423 hasAuthorship W2107982423A5019489319 @default.
• W2107982423 hasAuthorship W2107982423A5064519080 @default.
• W2107982423 hasAuthorship W2107982423A5076193656 @default.
• W2107982423 hasAuthorship W2107982423A5078158266 @default.
• W2107982423 hasAuthorship W2107982423A5079861531 @default.
• W2107982423 hasAuthorship W2107982423A5079881414 @default.
• W2107982423 hasConcept C121608353 @default.
• W2107982423 hasConcept C126322002 @default.
• W2107982423 hasConcept C150903083 @default.
• W2107982423 hasConcept C155672457 @default.
• W2107982423 hasConcept C171250308 @default.
• W2107982423 hasConcept C181389837 @default.
• W2107982423 hasConcept C185592680 @default.
• W2107982423 hasConcept C190283241 @default.
• W2107982423 hasConcept C192562407 @default.
• W2107982423 hasConcept C202751555 @default.
• W2107982423 hasConcept C204399865 @default.
• W2107982423 hasConcept C207001950 @default.
• W2107982423 hasConcept C2781190966 @default.
• W2107982423 hasConcept C55493867 @default.
• W2107982423 hasConcept C71924100 @default.
• W2107982423 hasConcept C86181022 @default.
• W2107982423 hasConcept C86803240 @default.
• W2107982423 hasConcept C98274493 @default.
• W2107982423 hasConceptScore W2107982423C121608353 @default.
• W2107982423 hasConceptScore W2107982423C126322002 @default.
• W2107982423 hasConceptScore W2107982423C150903083 @default.
• W2107982423 hasConceptScore W2107982423C155672457 @default.
• W2107982423 hasConceptScore W2107982423C171250308 @default.
• W2107982423 hasConceptScore W2107982423C181389837 @default.
• W2107982423 hasConceptScore W2107982423C185592680 @default.
• W2107982423 hasConceptScore W2107982423C190283241 @default.
• W2107982423 hasConceptScore W2107982423C192562407 @default.
• W2107982423 hasConceptScore W2107982423C202751555 @default.
• W2107982423 hasConceptScore W2107982423C204399865 @default.
• W2107982423 hasConceptScore W2107982423C207001950 @default.
• W2107982423 hasConceptScore W2107982423C2781190966 @default.
• W2107982423 hasConceptScore W2107982423C55493867 @default.
• W2107982423 hasConceptScore W2107982423C71924100 @default.

• next