Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108010726> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2108010726 endingPage "52" @default.
- W2108010726 startingPage "48" @default.
- W2108010726 abstract "Abstract: The effects of subchronic treatment with the antipsychotic drugs fluphenazine and sulpiride on the sensitivity of peripheral neuronal dopamine receptors and central dopamine autoreceptors were evaluated. The ability of apomorphine, a dopamine agonist, to inhibit electrically induced sympathetic vasoconstriction in pithed rats, and apomorphine-induced inhibition of spontaneous locomotor activity in awake rats were used as indices of peripheral and central dopamine receptor sensitivity, respectively. A single injection of fluphenazine decanoate, a long-acting preparation of fluphenazine, enhanced the central locomotor inhibitory effect of low doses of apomorphine 4 and 6 weeks after drug administration, whereas the antidopaminergic effect on peripheral dopamine receptors was prolonged and persisted at least up to 6 weeks. In another set of experiments rats were treated with fluphenazine hydrochloride and sulpiride for 10 days and subsequently challenged with apomorphine after various withdrawal times. Both antipsychotic drugs augmented the inhibitory effect of apomorphine in the periphery, although the time courses of the potentiation were different. Both treatments also enhanced the locomotor inhibitory effect of apomorphine. These results are in line with our previous finding that long-term treatment with dopamine antagonists can induce neuronal dopamine receptor up-regulation also outside the central nervous system. Peripheral neuronal dopamine receptors thus show similar adaptive responses to long-term blockade as central dopamine autoreceptors, and may serve as a useful experimental model in studies concerned with mechanisms of dopaminergic autoregulation in the central nervous system." @default.
- W2108010726 created "2016-06-24" @default.
- W2108010726 creator A5022252286 @default.
- W2108010726 creator A5069837531 @default.
- W2108010726 creator A5071467649 @default.
- W2108010726 creator A5078460231 @default.
- W2108010726 date "1987-07-01" @default.
- W2108010726 modified "2023-10-16" @default.
- W2108010726 title "Alterations in Peripheral and Central Dopamine Receptor Sensitivity after Subchronic Treatment with Fluphenazine and Sulpiride" @default.
- W2108010726 cites W1971409205 @default.
- W2108010726 cites W1975216040 @default.
- W2108010726 cites W1975520016 @default.
- W2108010726 cites W1994429247 @default.
- W2108010726 cites W2013991313 @default.
- W2108010726 cites W2044706500 @default.
- W2108010726 cites W2045642593 @default.
- W2108010726 cites W2054953918 @default.
- W2108010726 cites W2060167838 @default.
- W2108010726 cites W2064028030 @default.
- W2108010726 cites W2083095953 @default.
- W2108010726 cites W2092179324 @default.
- W2108010726 doi "https://doi.org/10.1111/j.1600-0773.1987.tb01771.x" @default.
- W2108010726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3628181" @default.
- W2108010726 hasPublicationYear "1987" @default.
- W2108010726 type Work @default.
- W2108010726 sameAs 2108010726 @default.
- W2108010726 citedByCount "4" @default.
- W2108010726 crossrefType "journal-article" @default.
- W2108010726 hasAuthorship W2108010726A5022252286 @default.
- W2108010726 hasAuthorship W2108010726A5069837531 @default.
- W2108010726 hasAuthorship W2108010726A5071467649 @default.
- W2108010726 hasAuthorship W2108010726A5078460231 @default.
- W2108010726 hasConcept C120069818 @default.
- W2108010726 hasConcept C126322002 @default.
- W2108010726 hasConcept C134018914 @default.
- W2108010726 hasConcept C137183658 @default.
- W2108010726 hasConcept C170493617 @default.
- W2108010726 hasConcept C185592680 @default.
- W2108010726 hasConcept C199596767 @default.
- W2108010726 hasConcept C2776978879 @default.
- W2108010726 hasConcept C2777525119 @default.
- W2108010726 hasConcept C2778938600 @default.
- W2108010726 hasConcept C2780806966 @default.
- W2108010726 hasConcept C2780948584 @default.
- W2108010726 hasConcept C513476851 @default.
- W2108010726 hasConcept C71924100 @default.
- W2108010726 hasConcept C8439214 @default.
- W2108010726 hasConcept C98274493 @default.
- W2108010726 hasConceptScore W2108010726C120069818 @default.
- W2108010726 hasConceptScore W2108010726C126322002 @default.
- W2108010726 hasConceptScore W2108010726C134018914 @default.
- W2108010726 hasConceptScore W2108010726C137183658 @default.
- W2108010726 hasConceptScore W2108010726C170493617 @default.
- W2108010726 hasConceptScore W2108010726C185592680 @default.
- W2108010726 hasConceptScore W2108010726C199596767 @default.
- W2108010726 hasConceptScore W2108010726C2776978879 @default.
- W2108010726 hasConceptScore W2108010726C2777525119 @default.
- W2108010726 hasConceptScore W2108010726C2778938600 @default.
- W2108010726 hasConceptScore W2108010726C2780806966 @default.
- W2108010726 hasConceptScore W2108010726C2780948584 @default.
- W2108010726 hasConceptScore W2108010726C513476851 @default.
- W2108010726 hasConceptScore W2108010726C71924100 @default.
- W2108010726 hasConceptScore W2108010726C8439214 @default.
- W2108010726 hasConceptScore W2108010726C98274493 @default.
- W2108010726 hasIssue "1" @default.
- W2108010726 hasLocation W21080107261 @default.
- W2108010726 hasLocation W21080107262 @default.
- W2108010726 hasOpenAccess W2108010726 @default.
- W2108010726 hasPrimaryLocation W21080107261 @default.
- W2108010726 hasRelatedWork W177623526 @default.
- W2108010726 hasRelatedWork W1997402918 @default.
- W2108010726 hasRelatedWork W2013867504 @default.
- W2108010726 hasRelatedWork W2017850080 @default.
- W2108010726 hasRelatedWork W2029903571 @default.
- W2108010726 hasRelatedWork W2045946881 @default.
- W2108010726 hasRelatedWork W2054764534 @default.
- W2108010726 hasRelatedWork W2085400639 @default.
- W2108010726 hasRelatedWork W2108010726 @default.
- W2108010726 hasRelatedWork W2249516468 @default.
- W2108010726 hasVolume "61" @default.
- W2108010726 isParatext "false" @default.
- W2108010726 isRetracted "false" @default.
- W2108010726 magId "2108010726" @default.
- W2108010726 workType "article" @default.