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• W2108024871 startingPage "161" @default.
• W2108024871 abstract "In this study, we explore the effect of the lack of myelin on the diffusion characteristics and diffusion anisotropy obtained from high b-value q-space diffusion-weighted MRI (q-space DWI) in excised rat spinal cords. Twenty-one-day-old myelin-deficient (md) mutant (N=6) and control rats (N=6) were used in this study. The MRI protocol included multi-slice T1, T2, proton density (PD) MR images and high b-value q-space diffusion MRI measured perpendicular and parallel to the fibers of the spine. q-Space displacement and probability maps, in both directions, as well as displacement anisotropy maps, were computed from the diffusion data. At the end of the MRI protocol, representative spinal cords from both groups were subjected to electron microscopy (EM). The md spinal cords show different gray/white matter contrast in the T1, T2 and PD MR images as compared with controls. In addition, the mean displacement extracted from the high b-value q-space diffusion data was found to be dramatically higher in the white matter (WM) of the md spinal cords than the controls when diffusion was measured perpendicular and parallel to the fibers of the spine. However, interestingly, at the diffusion time used in the present study, the difference in the WM displacement anisotropies of the two groups was not found to be statistically significant. Myelin was found to have a pronounced effect on the diffusion characteristics of water in WM but less so on the diffusion anisotropy observed at the diffusion time used in the present study." @default.
• W2108024871 created "2016-06-24" @default.
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• W2108024871 date "2006-02-01" @default.
• W2108024871 modified "2023-09-27" @default.
• W2108024871 title "High b-value q-space diffusion MRI in myelin-deficient rat spinal cords" @default.
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• W2108024871 doi "https://doi.org/10.1016/j.mri.2005.10.029" @default.
• W2108024871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16455404" @default.
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