Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108040669> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2108040669 endingPage "917" @default.
- W2108040669 startingPage "912" @default.
- W2108040669 abstract "Zoladex, a sustained-release luteinizing hormone--releasing hormone (LHRH) analogue administered by subcutaneous injection every 28 days, was evaluated at three dose levels in 46 men with untreated advanced prostate cancer. All three Zoladex doses yielded similar endocrinologic effects. After initial transient increases in serum luteinizing hormone, follicle-stimulating hormone, and testosterone concentrations, serum testosterone was suppressed uniformly to castration levels within 22 days. At a median follow-up of 41 weeks, Zoladex had maintained persistent suppression of serum testosterone. Measurements of serum Zoladex levels indicated that release of the drug from the injected depot was sustained over a period of 1 month and that there was no drug accumulation as evaluated over an initial 3-month period. No antibodies to Zoladex were detected. Tumor regression rates and side effects with Zoladex therapy were similar to those reported with daily injections of subcutaneous LHRH therapy. Signs and symptoms consistent with a brief tumor flare after the first injection of the LHRH analogue were noted in eight (17%) of the study entrants. Spinal cord compression was observed in two patients within 1 week from the onset of therapy. Zoladex is considered to be an effective, sustained-release LHRH analogue for the treatment of patients with prostate cancer." @default.
- W2108040669 created "2016-06-24" @default.
- W2108040669 creator A5005756055 @default.
- W2108040669 creator A5017279103 @default.
- W2108040669 creator A5032597780 @default.
- W2108040669 creator A5040125749 @default.
- W2108040669 creator A5057559668 @default.
- W2108040669 creator A5060343841 @default.
- W2108040669 creator A5065161783 @default.
- W2108040669 creator A5066037351 @default.
- W2108040669 date "1987-06-01" @default.
- W2108040669 modified "2023-09-27" @default.
- W2108040669 title "Zoladex: a sustained-release, monthly luteinizing hormone-releasing hormone analogue for the treatment of advanced prostate cancer." @default.
- W2108040669 cites W1495571942 @default.
- W2108040669 cites W1496003929 @default.
- W2108040669 cites W1736071032 @default.
- W2108040669 cites W1894618651 @default.
- W2108040669 cites W1977543620 @default.
- W2108040669 cites W1980806708 @default.
- W2108040669 cites W2012755298 @default.
- W2108040669 cites W2013895507 @default.
- W2108040669 cites W2074185602 @default.
- W2108040669 cites W2074703914 @default.
- W2108040669 cites W2077563872 @default.
- W2108040669 cites W2081537348 @default.
- W2108040669 cites W2082102453 @default.
- W2108040669 cites W2087873780 @default.
- W2108040669 cites W2276072298 @default.
- W2108040669 cites W2473586346 @default.
- W2108040669 doi "https://doi.org/10.1200/jco.1987.5.6.912" @default.
- W2108040669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2953870" @default.
- W2108040669 hasPublicationYear "1987" @default.
- W2108040669 type Work @default.
- W2108040669 sameAs 2108040669 @default.
- W2108040669 citedByCount "55" @default.
- W2108040669 countsByYear W21080406692012 @default.
- W2108040669 countsByYear W21080406692015 @default.
- W2108040669 countsByYear W21080406692017 @default.
- W2108040669 countsByYear W21080406692018 @default.
- W2108040669 countsByYear W21080406692019 @default.
- W2108040669 countsByYear W21080406692021 @default.
- W2108040669 countsByYear W21080406692022 @default.
- W2108040669 countsByYear W21080406692023 @default.
- W2108040669 crossrefType "journal-article" @default.
- W2108040669 hasAuthorship W2108040669A5005756055 @default.
- W2108040669 hasAuthorship W2108040669A5017279103 @default.
- W2108040669 hasAuthorship W2108040669A5032597780 @default.
- W2108040669 hasAuthorship W2108040669A5040125749 @default.
- W2108040669 hasAuthorship W2108040669A5057559668 @default.
- W2108040669 hasAuthorship W2108040669A5060343841 @default.
- W2108040669 hasAuthorship W2108040669A5065161783 @default.
- W2108040669 hasAuthorship W2108040669A5066037351 @default.
- W2108040669 hasConcept C121608353 @default.
- W2108040669 hasConcept C126322002 @default.
- W2108040669 hasConcept C126894567 @default.
- W2108040669 hasConcept C134018914 @default.
- W2108040669 hasConcept C2776235491 @default.
- W2108040669 hasConcept C2776390293 @default.
- W2108040669 hasConcept C2778043895 @default.
- W2108040669 hasConcept C2778575703 @default.
- W2108040669 hasConcept C2779279165 @default.
- W2108040669 hasConcept C2779279991 @default.
- W2108040669 hasConcept C2780192828 @default.
- W2108040669 hasConcept C71315377 @default.
- W2108040669 hasConcept C71924100 @default.
- W2108040669 hasConceptScore W2108040669C121608353 @default.
- W2108040669 hasConceptScore W2108040669C126322002 @default.
- W2108040669 hasConceptScore W2108040669C126894567 @default.
- W2108040669 hasConceptScore W2108040669C134018914 @default.
- W2108040669 hasConceptScore W2108040669C2776235491 @default.
- W2108040669 hasConceptScore W2108040669C2776390293 @default.
- W2108040669 hasConceptScore W2108040669C2778043895 @default.
- W2108040669 hasConceptScore W2108040669C2778575703 @default.
- W2108040669 hasConceptScore W2108040669C2779279165 @default.
- W2108040669 hasConceptScore W2108040669C2779279991 @default.
- W2108040669 hasConceptScore W2108040669C2780192828 @default.
- W2108040669 hasConceptScore W2108040669C71315377 @default.
- W2108040669 hasConceptScore W2108040669C71924100 @default.
- W2108040669 hasIssue "6" @default.
- W2108040669 hasLocation W21080406691 @default.
- W2108040669 hasLocation W21080406692 @default.
- W2108040669 hasOpenAccess W2108040669 @default.
- W2108040669 hasPrimaryLocation W21080406691 @default.
- W2108040669 hasRelatedWork W1971309574 @default.
- W2108040669 hasRelatedWork W1991634850 @default.
- W2108040669 hasRelatedWork W2025304600 @default.
- W2108040669 hasRelatedWork W2037063612 @default.
- W2108040669 hasRelatedWork W2052998204 @default.
- W2108040669 hasRelatedWork W2061429954 @default.
- W2108040669 hasRelatedWork W2064034534 @default.
- W2108040669 hasRelatedWork W2132392207 @default.
- W2108040669 hasRelatedWork W2169932845 @default.
- W2108040669 hasRelatedWork W2411910748 @default.
- W2108040669 hasVolume "5" @default.
- W2108040669 isParatext "false" @default.
- W2108040669 isRetracted "false" @default.
- W2108040669 magId "2108040669" @default.
- W2108040669 workType "article" @default.