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• W2108046364 abstract "<h2>Abstract</h2> McBrier NM, Lekan JM, Druhan LJ, Devor ST, Merrick MA. Therapeutic ultrasound decreased mechno-growth factor messenger ribonucleic acid expression after muscle contusion injury. <h3>Objective</h3> To examine the influence of nonthermal ultrasound on mechano-growth factor (MGF) messenger ribonucleic acid (mRNA) expression after blunt trauma. <h3>Design</h3> A 2×4 factorial multivariate analysis of variance design. <h3>Setting</h3> University research laboratory. <h3>Animals</h3> Thirty-six 3- to 4-month-old male Wistar rats (mean weight, 280.8±21.5g). Thirty-two received a bilateral contusion injury to the gastrocnemius via a drop mass technique. Four were control animals. <h3>Intervention</h3> Ultrasound treatment (frequency, 3MHz; intensity, 0.3W/cm²; continuous duty cycle) was started 24 hours postinjury and delivered for 5 minutes daily on 4 consecutive days. Treatment was on the left hindlimb and the contralateral right hindlimb was the nonultrasound control. <h3>Main Outcome Measures</h3> Muscle mass (in grams) and MGF mRNA expression as measured via real-time reverse transcriptase polymerase chain reaction. <h3>Results</h3> Ultrasound had no effect on muscle mass (F_1,28=2.723, <i>P</i>=.110, 1−β=.357, η²=.089). Ultrasound treatments decreased MGF mRNA expression in the treated limb compared with the nontreated hindlimb (F_1,28=6.605, <i>P</i>=.016, 1−β=.699, η²=.191). <h3>Conclusions</h3> The nonthermal ultrasound treatments resulted in decreased MGF mRNA expression after blunt trauma to the gastrocnemius muscles." @default.
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• W2108046364 date "2007-07-01" @default.
• W2108046364 modified "2023-09-27" @default.
• W2108046364 title "Therapeutic Ultrasound Decreases Mechano-Growth Factor Messenger Ribonucleic Acid Expression After Muscle Contusion Injury" @default.
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• W2108046364 doi "https://doi.org/10.1016/j.apmr.2007.04.005" @default.
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