Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108047414> ?p ?o ?g. }
- W2108047414 abstract "Upper gastrointestinal (GI) tumors, including adenocarcinoma of the esophagus, stomach, pancreas, and biliary tree, have traditionally been difficult to treat with cytotoxic chemotherapeutic agents. There has been little drug development success in treating these cancers over the last 20 years, perhaps a reflection of a combination of the aggressive biology of these tumors, the void in effective and specific drug development for these varied tumors, and the lack of properly designed, biologically-based clinical trials. Recently, so called targeted agents have risen to the forefront in the care of cancer patients and have made strong impacts in many areas of oncology, particularly gastrointestinal stromal tumors (GIST), colon, breast, and lung cancers. Unfortunately, slow progress has been made using such agents in upper GI tumors. However, more recently, trials in some tumor types have demonstrated gains in progression free survival and overall survival. In this review, we discuss the drugs and pathways that have been most successful in the treatment of upper GI tumors and present the relevant data supporting their use for each tumor site. Additionally, we will explore a few novel pathways that may prove effective in the treatment of upper GI malignancies in the near future." @default.
- W2108047414 created "2016-06-24" @default.
- W2108047414 creator A5008288310 @default.
- W2108047414 creator A5014350537 @default.
- W2108047414 creator A5021077843 @default.
- W2108047414 creator A5052243751 @default.
- W2108047414 creator A5087295236 @default.
- W2108047414 date "2011-01-01" @default.
- W2108047414 modified "2023-09-27" @default.
- W2108047414 title "Targeting metastatic upper gastrointestinal adenocarcinomas" @default.
- W2108047414 cites W1483706688 @default.
- W2108047414 cites W1508582865 @default.
- W2108047414 cites W1573363574 @default.
- W2108047414 cites W1585922331 @default.
- W2108047414 cites W1594815607 @default.
- W2108047414 cites W1607596367 @default.
- W2108047414 cites W1761594004 @default.
- W2108047414 cites W1931508686 @default.
- W2108047414 cites W1964290462 @default.
- W2108047414 cites W1973268287 @default.
- W2108047414 cites W1973918329 @default.
- W2108047414 cites W1976651872 @default.
- W2108047414 cites W1976742288 @default.
- W2108047414 cites W1978833015 @default.
- W2108047414 cites W1980329905 @default.
- W2108047414 cites W1981989535 @default.
- W2108047414 cites W1983341583 @default.
- W2108047414 cites W1983763042 @default.
- W2108047414 cites W1984379066 @default.
- W2108047414 cites W1984736455 @default.
- W2108047414 cites W1985046929 @default.
- W2108047414 cites W1987825791 @default.
- W2108047414 cites W1988655450 @default.
- W2108047414 cites W1989313612 @default.
- W2108047414 cites W1990199684 @default.
- W2108047414 cites W1992408996 @default.
- W2108047414 cites W1992885568 @default.
- W2108047414 cites W1994193851 @default.
- W2108047414 cites W1995811009 @default.
- W2108047414 cites W1996831788 @default.
- W2108047414 cites W2001540794 @default.
- W2108047414 cites W2002355858 @default.
- W2108047414 cites W2003500892 @default.
- W2108047414 cites W2005334224 @default.
- W2108047414 cites W2005560019 @default.
- W2108047414 cites W2009007206 @default.
- W2108047414 cites W2014300705 @default.
- W2108047414 cites W2017018900 @default.
- W2108047414 cites W2017137985 @default.
- W2108047414 cites W2020509813 @default.
- W2108047414 cites W2020691941 @default.
- W2108047414 cites W2026405645 @default.
- W2108047414 cites W2027379868 @default.
- W2108047414 cites W2031317888 @default.
- W2108047414 cites W2032347891 @default.
- W2108047414 cites W2034058449 @default.
- W2108047414 cites W2034515307 @default.
- W2108047414 cites W2036287744 @default.
- W2108047414 cites W2039633811 @default.
- W2108047414 cites W2039640335 @default.
- W2108047414 cites W2040923206 @default.
- W2108047414 cites W2045795713 @default.
- W2108047414 cites W2054870962 @default.
- W2108047414 cites W2055296003 @default.
- W2108047414 cites W2057969219 @default.
- W2108047414 cites W2057988063 @default.
- W2108047414 cites W2058016050 @default.
- W2108047414 cites W2058636642 @default.
- W2108047414 cites W2059456940 @default.
- W2108047414 cites W2061342543 @default.
- W2108047414 cites W2062628269 @default.
- W2108047414 cites W2064047613 @default.
- W2108047414 cites W2068110847 @default.
- W2108047414 cites W2071359561 @default.
- W2108047414 cites W2077239497 @default.
- W2108047414 cites W2080557886 @default.
- W2108047414 cites W2080663543 @default.
- W2108047414 cites W2083452953 @default.
- W2108047414 cites W2084506573 @default.
- W2108047414 cites W2086152184 @default.
- W2108047414 cites W2088601895 @default.
- W2108047414 cites W2090261930 @default.
- W2108047414 cites W2092147865 @default.
- W2108047414 cites W2095839230 @default.
- W2108047414 cites W2097642908 @default.
- W2108047414 cites W2106036268 @default.
- W2108047414 cites W2106390123 @default.
- W2108047414 cites W2106787323 @default.
- W2108047414 cites W2108707301 @default.
- W2108047414 cites W2109746877 @default.
- W2108047414 cites W2111039168 @default.
- W2108047414 cites W2113222623 @default.
- W2108047414 cites W2113492051 @default.
- W2108047414 cites W2115261608 @default.
- W2108047414 cites W2115497785 @default.
- W2108047414 cites W2116005493 @default.
- W2108047414 cites W2118520585 @default.
- W2108047414 cites W2119823629 @default.
- W2108047414 cites W2121120744 @default.
- W2108047414 cites W2121461794 @default.