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• W2108065629 endingPage "360" @default.
• W2108065629 startingPage "343" @default.
• W2108065629 abstract "Glutamate is the principal excitatory neurotransmitter in the mammalian central nervous system. After release from presynaptic terminals, glutamate binds to both ionotropic and metabotropic receptors to mediate fast, slow, and persistent effects on synaptic transmission and integrity. There are three types of ionotropic glutamate receptors. N-Methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA), and kainate receptors are principally activated by the agonist bearing its name and are permeable to cationic flux; hence, their activation results in membrane depolarization. All ionotropic glutamate receptors are believed to be composed of four distinct subunits, each of which is topologically arranged with three transmembrane-spanning and one pore-lining (hairpin loop) domain. In contrast, metabotropic glutamate receptors are G protein (guanine nucleotide-binding protein) -coupled receptors linked to second-messenger systems. Group I metabotropic glutamate receptors are linked to phospholipase C, which results in phosphoinositide hydrolysis and release of calcium from intracellular stores. Group II and group III metabotropic glutamate receptors are negatively linked to adenylate cyclase, which catalyzes the production of cyclic adenosine monophosphate. Each metabotropic glutamate receptor is composed of seven transmembrane-spanning domains, similar to other members of the superfamily of metabotropic receptors, which includes noradrenergic, muscarinic acetylcholinergic, dopaminergic, serotonergic (except type 3 receptors), and gamma-aminobutyric acid (GABA) type B receptors. This review summarizes the relevant molecular biology and ontogeny of glutamate receptors in the central nervous system and highlights some of the roles that they can play during brain development and in certain disease states." @default.
• W2108065629 created "2016-06-24" @default.
• W2108065629 creator A5010085174 @default.
• W2108065629 creator A5068432879 @default.
• W2108065629 creator A5078669606 @default.
• W2108065629 date "2004-05-01" @default.
• W2108065629 modified "2023-10-13" @default.
• W2108065629 title "Molecular Biology and Ontogeny of Glutamate Receptors in the Mammalian Central Nervous System" @default.
• W2108065629 cites W111663151 @default.
• W2108065629 cites W1483876599 @default.
• W2108065629 cites W1487123995 @default.
• W2108065629 cites W1502426712 @default.
• W2108065629 cites W1503789839 @default.
• W2108065629 cites W1504738854 @default.
• W2108065629 cites W1514879561 @default.
• W2108065629 cites W1519235682 @default.
• W2108065629 cites W1536892466 @default.
• W2108065629 cites W1537179351 @default.
• W2108065629 cites W1551261730 @default.
• W2108065629 cites W1554753026 @default.
• W2108065629 cites W1564717701 @default.
• W2108065629 cites W1571689838 @default.
• W2108065629 cites W1572972152 @default.
• W2108065629 cites W1575582664 @default.
• W2108065629 cites W1583433785 @default.
• W2108065629 cites W1592516385 @default.
• W2108065629 cites W1594111906 @default.
• W2108065629 cites W1594884846 @default.
• W2108065629 cites W1595843790 @default.
• W2108065629 cites W1599073422 @default.
• W2108065629 cites W1600525795 @default.
• W2108065629 cites W1603732963 @default.
• W2108065629 cites W1605336512 @default.
• W2108065629 cites W1606946990 @default.
• W2108065629 cites W1608934724 @default.
• W2108065629 cites W1612819372 @default.
• W2108065629 cites W1629617176 @default.
• W2108065629 cites W1654126567 @default.
• W2108065629 cites W1662302126 @default.
• W2108065629 cites W1673170827 @default.
• W2108065629 cites W1729062978 @default.
• W2108065629 cites W1753537936 @default.
• W2108065629 cites W1755875208 @default.
• W2108065629 cites W1790244735 @default.
• W2108065629 cites W1823231128 @default.
• W2108065629 cites W1862839122 @default.
• W2108065629 cites W1876061808 @default.
• W2108065629 cites W1881543710 @default.
• W2108065629 cites W1919210158 @default.
• W2108065629 cites W1941050038 @default.
• W2108065629 cites W1948270772 @default.
• W2108065629 cites W1962526731 @default.
• W2108065629 cites W1963989698 @default.
• W2108065629 cites W1964281319 @default.
• W2108065629 cites W1964409581 @default.
• W2108065629 cites W1965377078 @default.
• W2108065629 cites W1966673980 @default.
• W2108065629 cites W1968028177 @default.
• W2108065629 cites W1969077909 @default.
• W2108065629 cites W1970053578 @default.
• W2108065629 cites W1970106628 @default.
• W2108065629 cites W1970393142 @default.
• W2108065629 cites W1970753953 @default.
• W2108065629 cites W1971869900 @default.
• W2108065629 cites W1972183007 @default.
• W2108065629 cites W1972697876 @default.
• W2108065629 cites W1974424738 @default.
• W2108065629 cites W1975311573 @default.
• W2108065629 cites W1975342713 @default.
• W2108065629 cites W1975522748 @default.
• W2108065629 cites W1975944686 @default.
• W2108065629 cites W1976289522 @default.
• W2108065629 cites W1977850041 @default.
• W2108065629 cites W1977887400 @default.
• W2108065629 cites W1978817835 @default.
• W2108065629 cites W1980642537 @default.
• W2108065629 cites W1983948601 @default.
• W2108065629 cites W1984321841 @default.
• W2108065629 cites W1984909998 @default.
• W2108065629 cites W1985220401 @default.
• W2108065629 cites W1985815097 @default.
• W2108065629 cites W1986923087 @default.
• W2108065629 cites W1987376653 @default.
• W2108065629 cites W1988633143 @default.
• W2108065629 cites W1989938166 @default.
• W2108065629 cites W1990374926 @default.
• W2108065629 cites W1990625157 @default.
• W2108065629 cites W1990711246 @default.
• W2108065629 cites W1991363361 @default.
• W2108065629 cites W1996456984 @default.
• W2108065629 cites W1996542032 @default.
• W2108065629 cites W1996611220 @default.
• W2108065629 cites W1996712322 @default.
• W2108065629 cites W1997568797 @default.
• W2108065629 cites W1998347917 @default.
• W2108065629 cites W1998659120 @default.
• W2108065629 cites W1999968276 @default.
• W2108065629 cites W2000756368 @default.

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