FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108082148> ?p ?o ?g. }

• W2108082148 endingPage "105" @default.
• W2108082148 startingPage "101" @default.
• W2108082148 abstract "Background The concentrations of fibrinogen, factor VII and VIII, von Willebrand factor, plasminogen activator inhibitor-1 (PAI-1), and tissue plasminogen activator have been associated with coronary-heart disease. In addition, polymorphisms in the genes coding for fibrinogen, factor VII, PA-1, and factor XIII have been reported to affect both protein concentrations and cardiovascular disease risk. Methods We did a classic twin study to assess heritabilities of these haemostatic factors. We enrolled 1002 female twins; 149 pairs of monozygotic and 352 pairs of dizygotic twins. 89 monozygotic and 196 dizygotic twin pairs were analysed for factor VII. Findings Quantitative genetic model fitting showed that genetic factors contributed to about 41–75% of the variation in concentrations of fibrinogen, factor VII, factor VIII, PAI-1, tissue plasminogen activator, factor XIII A-subunit and B-subunit, and von Willebrand factor. Factor XIII activity showed higher (82%) and factor XIIa lower (38%) heritability. Interpretation We have shown that genetic factors have a major effect on plasma concentrations of haemostatic proteins. Our results stress the importance of research into the genetic regulation of proteins involved in haemostasis and atherothrombotic disorders, including myocardial infarction and stroke." @default.
• W2108082148 created "2016-06-24" @default.
• W2108082148 creator A5002163035 @default.
• W2108082148 creator A5008277035 @default.
• W2108082148 creator A5021289179 @default.
• W2108082148 creator A5027571680 @default.
• W2108082148 creator A5036249431 @default.
• W2108082148 date "2001-01-01" @default.
• W2108082148 modified "2023-10-02" @default.
• W2108082148 title "The genetics of haemostasis: a twin study" @default.
• W2108082148 cites W1558049852 @default.
• W2108082148 cites W176430369 @default.
• W2108082148 cites W1951511885 @default.
• W2108082148 cites W1962947285 @default.
• W2108082148 cites W1978039741 @default.
• W2108082148 cites W2001403178 @default.
• W2108082148 cites W2006419842 @default.
• W2108082148 cites W2039831544 @default.
• W2108082148 cites W2052371021 @default.
• W2108082148 cites W2070956296 @default.
• W2108082148 cites W2076500453 @default.
• W2108082148 cites W2084124265 @default.
• W2108082148 cites W2086303216 @default.
• W2108082148 cites W2088959855 @default.
• W2108082148 cites W2091126023 @default.
• W2108082148 cites W2101967721 @default.
• W2108082148 cites W2123342000 @default.
• W2108082148 cites W2124671503 @default.
• W2108082148 cites W2170126665 @default.
• W2108082148 cites W2205816315 @default.
• W2108082148 cites W2410199296 @default.
• W2108082148 cites W2418656637 @default.
• W2108082148 cites W2883545750 @default.
• W2108082148 cites W4229747314 @default.
• W2108082148 cites W4294570513 @default.
• W2108082148 cites W4300795993 @default.
• W2108082148 cites W77183089 @default.
• W2108082148 doi "https://doi.org/10.1016/s0140-6736(00)03541-8" @default.
• W2108082148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11197396" @default.
• W2108082148 hasPublicationYear "2001" @default.
• W2108082148 type Work @default.
• W2108082148 sameAs 2108082148 @default.
• W2108082148 citedByCount "279" @default.
• W2108082148 countsByYear W21080821482012 @default.
• W2108082148 countsByYear W21080821482013 @default.
• W2108082148 countsByYear W21080821482014 @default.
• W2108082148 countsByYear W21080821482015 @default.
• W2108082148 countsByYear W21080821482016 @default.
• W2108082148 countsByYear W21080821482017 @default.
• W2108082148 countsByYear W21080821482018 @default.
• W2108082148 countsByYear W21080821482019 @default.
• W2108082148 countsByYear W21080821482020 @default.
• W2108082148 countsByYear W21080821482021 @default.
• W2108082148 countsByYear W21080821482022 @default.
• W2108082148 countsByYear W21080821482023 @default.
• W2108082148 crossrefType "journal-article" @default.
• W2108082148 hasAuthorship W2108082148A5002163035 @default.
• W2108082148 hasAuthorship W2108082148A5008277035 @default.
• W2108082148 hasAuthorship W2108082148A5021289179 @default.
• W2108082148 hasAuthorship W2108082148A5027571680 @default.
• W2108082148 hasAuthorship W2108082148A5036249431 @default.
• W2108082148 hasConcept C126322002 @default.
• W2108082148 hasConcept C134018914 @default.
• W2108082148 hasConcept C161890455 @default.
• W2108082148 hasConcept C2776825266 @default.
• W2108082148 hasConcept C2778382381 @default.
• W2108082148 hasConcept C2779036427 @default.
• W2108082148 hasConcept C2779394231 @default.
• W2108082148 hasConcept C2779672106 @default.
• W2108082148 hasConcept C2779679481 @default.
• W2108082148 hasConcept C2780930249 @default.
• W2108082148 hasConcept C3017743773 @default.
• W2108082148 hasConcept C54355233 @default.
• W2108082148 hasConcept C71924100 @default.
• W2108082148 hasConcept C86803240 @default.
• W2108082148 hasConcept C89560881 @default.
• W2108082148 hasConceptScore W2108082148C126322002 @default.
• W2108082148 hasConceptScore W2108082148C134018914 @default.
• W2108082148 hasConceptScore W2108082148C161890455 @default.
• W2108082148 hasConceptScore W2108082148C2776825266 @default.
• W2108082148 hasConceptScore W2108082148C2778382381 @default.
• W2108082148 hasConceptScore W2108082148C2779036427 @default.
• W2108082148 hasConceptScore W2108082148C2779394231 @default.
• W2108082148 hasConceptScore W2108082148C2779672106 @default.
• W2108082148 hasConceptScore W2108082148C2779679481 @default.
• W2108082148 hasConceptScore W2108082148C2780930249 @default.
• W2108082148 hasConceptScore W2108082148C3017743773 @default.
• W2108082148 hasConceptScore W2108082148C54355233 @default.
• W2108082148 hasConceptScore W2108082148C71924100 @default.
• W2108082148 hasConceptScore W2108082148C86803240 @default.
• W2108082148 hasConceptScore W2108082148C89560881 @default.
• W2108082148 hasIssue "9250" @default.
• W2108082148 hasLocation W21080821481 @default.
• W2108082148 hasLocation W21080821482 @default.
• W2108082148 hasOpenAccess W2108082148 @default.
• W2108082148 hasPrimaryLocation W21080821481 @default.
• W2108082148 hasRelatedWork W1009563966 @default.
• W2108082148 hasRelatedWork W1974025836 @default.

• next