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- W2108085189 abstract "Background Use of electronic cigarettes (e‐cigarettes) and other nicotine containing products is increasing among women of reproductive age. The short‐ and long‐term effects of these products on both mother and fetus are unknown. Methods Because e‐cigarettes are nicotine delivery systems, we sought to conduct a comprehensive review of the effects of nicotine on the fetus. Results In utero nicotine exposure in animal models is associated with adverse effects for the offspring lung, cardiovascular system and brain. In the lung, this included reduced surface area, weight, and volume, as well as emphysema‐like lesions. In adulthood, exposed offspring demonstrate elevated blood pressure and increased perivascular adipose tissue. In the brain, exposure alters offspring serotonergic, dopaminergic, and norepinephrine networks, which in turn are associated with behavioral and cognitive impairments. We also review current data on the lack of efficacy of nicotine replacement therapy in pregnant women, and highlight different nicotine containing products such as snuff, snus, and hookah. Conclusion We conclude that no amount of nicotine is known to be safe during pregnancy, and studies specifically addressing this risk are crucial and an imminent public health issue. Birth Defects Research (Part A) 103:186–195, 2015. © 2014 Wiley Periodicals, Inc." @default.
- W2108085189 created "2016-06-24" @default.
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- W2108085189 date "2014-11-04" @default.
- W2108085189 modified "2023-10-16" @default.
- W2108085189 title "Is There Evidence for Potential Harm of Electronic Cigarette Use in Pregnancy?" @default.
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- W2108085189 doi "https://doi.org/10.1002/bdra.23333" @default.
- W2108085189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4830434" @default.
- W2108085189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25366492" @default.
- W2108085189 hasPublicationYear "2014" @default.
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