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• W2108103428 startingPage "e67346" @default.
• W2108103428 abstract "Alzheimer’s disease (AD), the most common form of dementia, shares many aspects of abnormal brain aging. We present a novel magnetic resonance imaging (MRI)-based biomarker that predicts the individual progression of mild cognitive impairment (MCI) to AD on the basis of pathological brain aging patterns. By employing kernel regression methods, the expression of normal brain-aging patterns forms the basis to estimate the brain age of a given new subject. If the estimated age is higher than the chronological age, a positive brain age gap estimation (BrainAGE) score indicates accelerated atrophy and is considered a risk factor for conversion to AD. Here, the BrainAGE framework was applied to predict the individual brain ages of 195 subjects with MCI at baseline, of which a total of 133 developed AD during 36 months of follow-up (corresponding to a pre-test probability of 68%). The ability of the BrainAGE framework to correctly identify MCI-converters was compared with the performance of commonly used cognitive scales, hippocampus volume, and state-of-the-art biomarkers derived from cerebrospinal fluid (CSF). With accuracy rates of up to 81%, BrainAGE outperformed all cognitive scales and CSF biomarkers in predicting conversion of MCI to AD within 3 years of follow-up. Each additional year in the BrainAGE score was associated with a 10% greater risk of developing AD (hazard rate: 1.10 [CI: 1.07–1.13]). Furthermore, the post-test probability was increased to 90% when using baseline BrainAGE scores to predict conversion to AD. The presented framework allows an accurate prediction even with multicenter data. Its fast and fully automated nature facilitates the integration into the clinical workflow. It can be exploited as a tool for screening as well as for monitoring treatment options." @default.
• W2108103428 created "2016-06-24" @default.
• W2108103428 creator A5007738782 @default.
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• W2108103428 date "2013-06-27" @default.
• W2108103428 modified "2023-10-18" @default.
• W2108103428 title "BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer’s Disease" @default.
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• W2108103428 cites W1980801609 @default.
• W2108103428 cites W1980842500 @default.
• W2108103428 cites W1997228011 @default.
• W2108103428 cites W1998088268 @default.
• W2108103428 cites W1999864873 @default.
• W2108103428 cites W2001648635 @default.
• W2108103428 cites W2004758461 @default.
• W2108103428 cites W2008301592 @default.
• W2108103428 cites W2009354197 @default.
• W2108103428 cites W2016740629 @default.
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• W2108103428 cites W2028590992 @default.
• W2108103428 cites W2033186302 @default.
• W2108103428 cites W2038003677 @default.
• W2108103428 cites W2041736553 @default.
• W2108103428 cites W2048970899 @default.
• W2108103428 cites W2049943618 @default.
• W2108103428 cites W2050445774 @default.
• W2108103428 cites W2054007740 @default.
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• W2108103428 cites W2067128590 @default.
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• W2108103428 cites W2085909714 @default.
• W2108103428 cites W2098265084 @default.
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• W2108103428 doi "https://doi.org/10.1371/journal.pone.0067346" @default.
• W2108103428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3695013" @default.
• W2108103428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23826273" @default.
• W2108103428 hasPublicationYear "2013" @default.
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