FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108103709> ?p ?o ?g. }

• W2108103709 endingPage "1102" @default.
• W2108103709 startingPage "1091" @default.
• W2108103709 abstract "Background The prebiotic nature of human milk oligosaccharides (HMOs) and increasing evidence of direct immunomodulatory effects of these sugars suggest that they may have some therapeutic potential in allergy. Here, we assess the effect of two HMOs, 2’-fucosyllactose and 6’-sialyllactose, on symptomatology and immune responses in an ovalbumin-sensitized mouse model of food allergy. Methods The effects of oral treatment with 2′-fucosyllactose and 6′-sialyllactose on anaphylactic symptoms induced by oral ovalbumin (OVA) challenge in sensitized mice were investigated. Mast cell functions in response to oral HMO treatment were also measured in the passive cutaneous anaphylaxis model, and direct effects on IgE-mediated degranulation of mast cells were assessed. Results Daily oral treatment with 2′-fucosyllactose or 6′-sialyllactose attenuated food allergy symptoms including diarrhea and hypothermia. Treatment with HMOs also suppressed antigen-induced increases in mouse mast cell protease-1 in serum and mast cell numbers in the intestine. These effects were associated with increases in the CD4+CD25+IL-10+ cell populations in the Peyer's patches and mesenteric lymph nodes, while 6′-sialyllactose also induced increased IL-10 and decreased TNF production in antigen-stimulated splenocytes. Both 2′-fucosyllactose and 6′-sialyllactose reduced the passive cutaneous anaphylaxis response, but only 6′-sialyllactose directly inhibited mast cell degranulation in vitro, at high concentrations. Conclusions Our results suggest that 2′-fucosyllactose and 6′-sialyllactose reduce the symptoms of food allergy through induction of IL-10+ T regulatory cells and indirect stabilization of mast cells. Thus, human milk oligosaccharides may have therapeutic potential in allergic disease." @default.
• W2108103709 created "2016-06-24" @default.
• W2108103709 creator A5004895028 @default.
• W2108103709 creator A5029445643 @default.
• W2108103709 creator A5037845261 @default.
• W2108103709 creator A5047416834 @default.
• W2108103709 creator A5063086849 @default.
• W2108103709 creator A5066075026 @default.
• W2108103709 date "2015-05-26" @default.
• W2108103709 modified "2023-10-06" @default.
• W2108103709 title "Attenuation of food allergy symptoms following treatment with human milk oligosaccharides in a mouse model" @default.
• W2108103709 cites W1487919162 @default.
• W2108103709 cites W1563194043 @default.
• W2108103709 cites W1632856850 @default.
• W2108103709 cites W1832400618 @default.
• W2108103709 cites W1959752346 @default.
• W2108103709 cites W1967839414 @default.
• W2108103709 cites W1969154910 @default.
• W2108103709 cites W1970091316 @default.
• W2108103709 cites W1976068711 @default.
• W2108103709 cites W1976900960 @default.
• W2108103709 cites W1981477517 @default.
• W2108103709 cites W1981859401 @default.
• W2108103709 cites W1984310252 @default.
• W2108103709 cites W1985504995 @default.
• W2108103709 cites W1986540555 @default.
• W2108103709 cites W1990330959 @default.
• W2108103709 cites W2006208839 @default.
• W2108103709 cites W2006346977 @default.
• W2108103709 cites W2009696737 @default.
• W2108103709 cites W2032529020 @default.
• W2108103709 cites W2032756559 @default.
• W2108103709 cites W2033177777 @default.
• W2108103709 cites W2035023446 @default.
• W2108103709 cites W2037379652 @default.
• W2108103709 cites W2039892708 @default.
• W2108103709 cites W2044482540 @default.
• W2108103709 cites W2047393644 @default.
• W2108103709 cites W2048320542 @default.
• W2108103709 cites W2051968753 @default.
• W2108103709 cites W2057086723 @default.
• W2108103709 cites W2060839471 @default.
• W2108103709 cites W2081066230 @default.
• W2108103709 cites W2087081536 @default.
• W2108103709 cites W2088748797 @default.
• W2108103709 cites W2108550035 @default.
• W2108103709 cites W2108873098 @default.
• W2108103709 cites W2110335769 @default.
• W2108103709 cites W2110444169 @default.
• W2108103709 cites W2114419796 @default.
• W2108103709 cites W2119381274 @default.
• W2108103709 cites W2121676188 @default.
• W2108103709 cites W2123070235 @default.
• W2108103709 cites W2128956666 @default.
• W2108103709 cites W2132654910 @default.
• W2108103709 cites W2134709529 @default.
• W2108103709 cites W2134837867 @default.
• W2108103709 cites W2146896376 @default.
• W2108103709 cites W2147280137 @default.
• W2108103709 cites W2148664250 @default.
• W2108103709 cites W2150968312 @default.
• W2108103709 cites W2152058975 @default.
• W2108103709 cites W2155927439 @default.
• W2108103709 cites W2157171377 @default.
• W2108103709 cites W2157886452 @default.
• W2108103709 cites W2162164999 @default.
• W2108103709 cites W2164386968 @default.
• W2108103709 cites W2165472257 @default.
• W2108103709 cites W2170211293 @default.
• W2108103709 doi "https://doi.org/10.1111/all.12650" @default.
• W2108103709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25966668" @default.
• W2108103709 hasPublicationYear "2015" @default.
• W2108103709 type Work @default.
• W2108103709 sameAs 2108103709 @default.
• W2108103709 citedByCount "120" @default.
• W2108103709 countsByYear W21081037092016 @default.
• W2108103709 countsByYear W21081037092017 @default.
• W2108103709 countsByYear W21081037092018 @default.
• W2108103709 countsByYear W21081037092019 @default.
• W2108103709 countsByYear W21081037092020 @default.
• W2108103709 countsByYear W21081037092021 @default.
• W2108103709 countsByYear W21081037092022 @default.
• W2108103709 countsByYear W21081037092023 @default.
• W2108103709 crossrefType "journal-article" @default.
• W2108103709 hasAuthorship W2108103709A5004895028 @default.
• W2108103709 hasAuthorship W2108103709A5029445643 @default.
• W2108103709 hasAuthorship W2108103709A5037845261 @default.
• W2108103709 hasAuthorship W2108103709A5047416834 @default.
• W2108103709 hasAuthorship W2108103709A5063086849 @default.
• W2108103709 hasAuthorship W2108103709A5066075026 @default.
• W2108103709 hasConcept C126322002 @default.
• W2108103709 hasConcept C141105273 @default.
• W2108103709 hasConcept C147483822 @default.
• W2108103709 hasConcept C159654299 @default.
• W2108103709 hasConcept C170493617 @default.
• W2108103709 hasConcept C203014093 @default.
• W2108103709 hasConcept C207480886 @default.
• W2108103709 hasConcept C2775933838 @default.

• next