FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108108310> ?p ?o ?g. }

• W2108108310 endingPage "1644" @default.
• W2108108310 startingPage "1637" @default.
• W2108108310 abstract "Current strategies for the immunotherapy of melanoma include augmentation of the immune response to tumor antigens represented by melanosomal proteins such as tyrosinase, gp100, and MART-1. The possibility that intentional targeting of tumor antigens representing normal proteins can result in autoimmune toxicity has been postulated but never demonstrated previously in humans. In this study, we describe a patient with metastatic melanoma who developed inflammatory lesions circumscribing pigmented areas of skin after an infusion of MART-1-specific CD8(+) T cell clones. Analysis of the infiltrating lymphocytes in skin and tumor biopsies using T cell-specific peptide-major histocompatibility complex tetramers demonstrated a localized predominance of MART-1-specific CD8(+) T cells (>28% of all CD8 T cells) that was identical to the infused clones (as confirmed by sequencing of the complementarity-determining region 3). In contrast to skin biopsies obtained from the patient before T cell infusion, postinfusion biopsies demonstrated loss of MART-1 expression, evidence of melanocyte damage, and the complete absence of melanocytes in affected regions of the skin. This study provides, for the first time, direct evidence in humans that antigen-specific immunotherapy can target not only antigen-positive tumor cells in vivo but also normal tissues expressing the shared tumor antigen." @default.
• W2108108310 created "2016-06-24" @default.
• W2108108310 creator A5002612454 @default.
• W2108108310 creator A5025539602 @default.
• W2108108310 creator A5028161783 @default.
• W2108108310 creator A5028479135 @default.
• W2108108310 creator A5030463228 @default.
• W2108108310 creator A5033216052 @default.
• W2108108310 creator A5033868959 @default.
• W2108108310 creator A5034536527 @default.
• W2108108310 creator A5084570861 @default.
• W2108108310 creator A5087281332 @default.
• W2108108310 date "2000-12-04" @default.
• W2108108310 modified "2023-10-11" @default.
• W2108108310 title "Melanocyte Destruction after Antigen-Specific Immunotherapy of Melanoma" @default.
• W2108108310 cites W1521600055 @default.
• W2108108310 cites W1589097025 @default.
• W2108108310 cites W1967577151 @default.
• W2108108310 cites W1983806918 @default.
• W2108108310 cites W1992847016 @default.
• W2108108310 cites W2010753175 @default.
• W2108108310 cites W2026470830 @default.
• W2108108310 cites W2053852480 @default.
• W2108108310 cites W2066964346 @default.
• W2108108310 cites W2067069532 @default.
• W2108108310 cites W2070329596 @default.
• W2108108310 cites W2080568999 @default.
• W2108108310 cites W2094682066 @default.
• W2108108310 cites W2096644099 @default.
• W2108108310 cites W2097610774 @default.
• W2108108310 cites W2107629538 @default.
• W2108108310 cites W2130185552 @default.
• W2108108310 cites W2130612676 @default.
• W2108108310 cites W2153746213 @default.
• W2108108310 cites W2159703967 @default.
• W2108108310 cites W2397128349 @default.
• W2108108310 cites W4241141024 @default.
• W2108108310 cites W4254092143 @default.
• W2108108310 cites W4375940934 @default.
• W2108108310 cites W2419575431 @default.
• W2108108310 doi "https://doi.org/10.1084/jem.192.11.1637" @default.
• W2108108310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2193107" @default.
• W2108108310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11104805" @default.
• W2108108310 hasPublicationYear "2000" @default.
• W2108108310 type Work @default.
• W2108108310 sameAs 2108108310 @default.
• W2108108310 citedByCount "415" @default.
• W2108108310 countsByYear W21081083102012 @default.
• W2108108310 countsByYear W21081083102013 @default.
• W2108108310 countsByYear W21081083102014 @default.
• W2108108310 countsByYear W21081083102015 @default.
• W2108108310 countsByYear W21081083102016 @default.
• W2108108310 countsByYear W21081083102017 @default.
• W2108108310 countsByYear W21081083102018 @default.
• W2108108310 countsByYear W21081083102019 @default.
• W2108108310 countsByYear W21081083102020 @default.
• W2108108310 countsByYear W21081083102021 @default.
• W2108108310 countsByYear W21081083102022 @default.
• W2108108310 countsByYear W21081083102023 @default.
• W2108108310 crossrefType "journal-article" @default.
• W2108108310 hasAuthorship W2108108310A5002612454 @default.
• W2108108310 hasAuthorship W2108108310A5025539602 @default.
• W2108108310 hasAuthorship W2108108310A5028161783 @default.
• W2108108310 hasAuthorship W2108108310A5028479135 @default.
• W2108108310 hasAuthorship W2108108310A5030463228 @default.
• W2108108310 hasAuthorship W2108108310A5033216052 @default.
• W2108108310 hasAuthorship W2108108310A5033868959 @default.
• W2108108310 hasAuthorship W2108108310A5034536527 @default.
• W2108108310 hasAuthorship W2108108310A5084570861 @default.
• W2108108310 hasAuthorship W2108108310A5087281332 @default.
• W2108108310 hasBestOaLocation W21081083101 @default.
• W2108108310 hasConcept C147483822 @default.
• W2108108310 hasConcept C154317977 @default.
• W2108108310 hasConcept C167672396 @default.
• W2108108310 hasConcept C202751555 @default.
• W2108108310 hasConcept C203014093 @default.
• W2108108310 hasConcept C207936829 @default.
• W2108108310 hasConcept C2776090121 @default.
• W2108108310 hasConcept C2777658100 @default.
• W2108108310 hasConcept C2777701055 @default.
• W2108108310 hasConcept C2779769559 @default.
• W2108108310 hasConcept C502942594 @default.
• W2108108310 hasConcept C55493867 @default.
• W2108108310 hasConcept C86803240 @default.
• W2108108310 hasConcept C8891405 @default.
• W2108108310 hasConceptScore W2108108310C147483822 @default.
• W2108108310 hasConceptScore W2108108310C154317977 @default.
• W2108108310 hasConceptScore W2108108310C167672396 @default.
• W2108108310 hasConceptScore W2108108310C202751555 @default.
• W2108108310 hasConceptScore W2108108310C203014093 @default.
• W2108108310 hasConceptScore W2108108310C207936829 @default.
• W2108108310 hasConceptScore W2108108310C2776090121 @default.
• W2108108310 hasConceptScore W2108108310C2777658100 @default.
• W2108108310 hasConceptScore W2108108310C2777701055 @default.
• W2108108310 hasConceptScore W2108108310C2779769559 @default.
• W2108108310 hasConceptScore W2108108310C502942594 @default.
• W2108108310 hasConceptScore W2108108310C55493867 @default.
• W2108108310 hasConceptScore W2108108310C86803240 @default.

• next