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- W2108122112 endingPage "2827" @default.
- W2108122112 startingPage "2821" @default.
- W2108122112 abstract "Medulloblastoma and other embronal brain tumors are similar in appearance and differentiation potential to neural stem and progenitor cells. Expression studies performed using human tumor samples, as well as the analysis of murine transgenic models, suggest that both multipotent cerebellar stem cells and lineage-restricted progenitors of the external germinal layer can be transformed into medulloblastoma by genetic alterations. These molecular changes frequently involve constitutive activation of signaling pathways such as Wnt, Hedgehog, and Notch, which play a key role in non-neoplastic neural stem cells. Pharmacologic blockade of the Hedgehog and Notch pathways suppresses the growth of medulloblastoma in culture and in vivo and may prove effective in targeting the small cancer stem-cell subpopulation required for tumor initiation and long-term propagation." @default.
- W2108122112 created "2016-06-24" @default.
- W2108122112 creator A5019028542 @default.
- W2108122112 creator A5027749624 @default.
- W2108122112 date "2008-06-10" @default.
- W2108122112 modified "2023-09-26" @default.
- W2108122112 title "Medulloblastoma Stem Cells" @default.
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- W2108122112 doi "https://doi.org/10.1200/jco.2007.15.2264" @default.
- W2108122112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4508659" @default.
- W2108122112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18539960" @default.