FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108125921> ?p ?o ?g. }

• W2108125921 endingPage "1642" @default.
• W2108125921 startingPage "1631" @default.
• W2108125921 abstract "To better understand the infertility of patients with Robertsonian translocation, the biochemical and ultrastructural apoptotic characteristics of apoptosis in the sperm of patients and fertile donors were studied. Ejaculated sperm samples of seven Robertsonian translocation carriers and seven fertile donors were analyzed after cryopreservation. The proportion of both viable and dead spermatozoa expressing activated caspases was detected by flow cytometry through the use of different specific carboxyfluorescein-labeled caspase inhibitors. Sperm DNA fragmentation was evaluated by the TUNEL method. The percentages of intact spermatozoa or spermatozoa with ultrastructural features of apoptosis, immaturity or necrosis were estimated by electron microscopy. Meiotic segregation analysis was performed by FISH. Significantly lower concentration, forward motility and normal morphology of spermatozoa were found in ejaculated samples of the Robertsonian patients than fertile donors. Compared with the control group, in Robertsonian translocation carriers: (i) the caspase assays showed a significantly increased (P < 0.05) proportion of viable spermatozoa with activated poly-caspases (57.4 versus 25.8%), caspase-3 (43.5 versus 13.4%), caspase-8 (44.4 versus 17.1%) and caspase-9 (42.4 versus 10.0%); (ii) the rate of DNA fragmentation was higher (26.3 versus 12.8%); and (iii) sperm ultrastructural examination highlighted a higher percentage of immature (28.0 versus 10.0%) and apoptotic (24.5 versus 18.5%) spermatozoa. FISH study showed predominant normal/balanced spermatozoa (78.34–85.53%). These results show a predominant proportion of balanced and normal gametes and higher numbers of spermatozoa showing apoptosis and immaturity features in oligoasthenozoospermic Robertsonian translocation carriers than in fertile donors. This suggests defects in spermatogenesis and especially spermiogenesis of these infertile patients." @default.
• W2108125921 created "2016-06-24" @default.
• W2108125921 creator A5001650322 @default.
• W2108125921 creator A5007955145 @default.
• W2108125921 creator A5016161783 @default.
• W2108125921 creator A5019314398 @default.
• W2108125921 creator A5024543533 @default.
• W2108125921 creator A5035371492 @default.
• W2108125921 creator A5038361626 @default.
• W2108125921 creator A5038412081 @default.
• W2108125921 creator A5058377092 @default.
• W2108125921 creator A5084823065 @default.
• W2108125921 date "2010-05-15" @default.
• W2108125921 modified "2023-09-25" @default.
• W2108125921 title "Apoptosis and meiotic segregation in ejaculated sperm from Robertsonian translocation carrier patients" @default.
• W2108125921 cites W1935661054 @default.
• W2108125921 cites W1965195727 @default.
• W2108125921 cites W1966597495 @default.
• W2108125921 cites W1969488808 @default.
• W2108125921 cites W1980331623 @default.
• W2108125921 cites W1983634739 @default.
• W2108125921 cites W2001341582 @default.
• W2108125921 cites W2005248340 @default.
• W2108125921 cites W2005462057 @default.
• W2108125921 cites W2013091489 @default.
• W2108125921 cites W2016721074 @default.
• W2108125921 cites W2023957744 @default.
• W2108125921 cites W2034789212 @default.
• W2108125921 cites W2043786747 @default.
• W2108125921 cites W2055662392 @default.
• W2108125921 cites W2061050258 @default.
• W2108125921 cites W2064127449 @default.
• W2108125921 cites W2064440766 @default.
• W2108125921 cites W2070344434 @default.
• W2108125921 cites W2078532650 @default.
• W2108125921 cites W2084798924 @default.
• W2108125921 cites W2090178053 @default.
• W2108125921 cites W2091261162 @default.
• W2108125921 cites W2094862035 @default.
• W2108125921 cites W2096191845 @default.
• W2108125921 cites W2098352346 @default.
• W2108125921 cites W2101406350 @default.
• W2108125921 cites W2106429976 @default.
• W2108125921 cites W2112435894 @default.
• W2108125921 cites W2118780616 @default.
• W2108125921 cites W2119448797 @default.
• W2108125921 cites W2121914287 @default.
• W2108125921 cites W2128324156 @default.
• W2108125921 cites W2132428901 @default.
• W2108125921 cites W2133923773 @default.
• W2108125921 cites W2142804096 @default.
• W2108125921 cites W2142911981 @default.
• W2108125921 cites W2146893907 @default.
• W2108125921 cites W2147707950 @default.
• W2108125921 cites W2149878918 @default.
• W2108125921 cites W2153769620 @default.
• W2108125921 cites W2159000683 @default.
• W2108125921 cites W2164465643 @default.
• W2108125921 cites W2166291746 @default.
• W2108125921 cites W2167693275 @default.
• W2108125921 cites W2346702349 @default.
• W2108125921 cites W4232748180 @default.
• W2108125921 cites W4249933468 @default.
• W2108125921 doi "https://doi.org/10.1093/humrep/deq113" @default.
• W2108125921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20472914" @default.
• W2108125921 hasPublicationYear "2010" @default.
• W2108125921 type Work @default.
• W2108125921 sameAs 2108125921 @default.
• W2108125921 citedByCount "34" @default.
• W2108125921 countsByYear W21081259212012 @default.
• W2108125921 countsByYear W21081259212013 @default.
• W2108125921 countsByYear W21081259212014 @default.
• W2108125921 countsByYear W21081259212015 @default.
• W2108125921 countsByYear W21081259212016 @default.
• W2108125921 countsByYear W21081259212017 @default.
• W2108125921 countsByYear W21081259212018 @default.
• W2108125921 countsByYear W21081259212019 @default.
• W2108125921 countsByYear W21081259212020 @default.
• W2108125921 countsByYear W21081259212021 @default.
• W2108125921 countsByYear W21081259212022 @default.
• W2108125921 countsByYear W21081259212023 @default.
• W2108125921 crossrefType "journal-article" @default.
• W2108125921 hasAuthorship W2108125921A5001650322 @default.
• W2108125921 hasAuthorship W2108125921A5007955145 @default.
• W2108125921 hasAuthorship W2108125921A5016161783 @default.
• W2108125921 hasAuthorship W2108125921A5019314398 @default.
• W2108125921 hasAuthorship W2108125921A5024543533 @default.
• W2108125921 hasAuthorship W2108125921A5035371492 @default.
• W2108125921 hasAuthorship W2108125921A5038361626 @default.
• W2108125921 hasAuthorship W2108125921A5038412081 @default.
• W2108125921 hasAuthorship W2108125921A5058377092 @default.
• W2108125921 hasAuthorship W2108125921A5084823065 @default.
• W2108125921 hasConcept C104317684 @default.
• W2108125921 hasConcept C138626823 @default.
• W2108125921 hasConcept C148196450 @default.
• W2108125921 hasConcept C16685009 @default.
• W2108125921 hasConcept C190283241 @default.
• W2108125921 hasConcept C2778093475 @default.

• next