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- W2108126259 abstract "<h3>Objective:</h3> To construct a model for depression in Parkinson disease (PD) and to study the relative contribution of PD-specific and nonspecific risk factors to this model. <h3>Methods:</h3> Structural equation modeling of direct and indirect associations of risk factors with the latent depression outcome using a cross-sectional dataset of 342 patients with PD. <h3>Results:</h3> A model with acceptable fit was generated that explained 41% of the variance in depression. In the final model, 3 PD-specific variables (increased disease duration, more severe motor symptoms, the use of levodopa) and 6 nonspecific variables (female sex, history of anxiety and/or depression, family history of depression, worse functioning on activities of daily living, and worse cognitive status) were maintained and significantly associated with depression. Nonspecific risk factors had a 3-times-higher influence in the model than PD-specific risk factors. <h3>Conclusion:</h3> In this cross-sectional study, we showed that nonspecific factors may be more prominent markers of depression than PD-specific factors. Accordingly, research on depression in PD should focus not only on factors associated with or specific for PD, but should also examine a wider scope of factors including general risk factors for depression, not specific for PD." @default.
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- W2108126259 date "2013-08-14" @default.
- W2108126259 modified "2023-10-18" @default.
- W2108126259 title "Modeling depression in Parkinson disease: Disease-specific and nonspecific risk factors" @default.
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- W2108126259 doi "https://doi.org/10.1212/wnl.0b013e3182a4a503" @default.
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