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• W2108134138 abstract "Spectacular success in preventing renal allograft rejection in rats was obtained over 40 yr ago using only the reactants of the response: donor-type antigen and homologous antiserum directed against donor-type antigen. Tolerance was antigen specific and sustained by persistent antigen of the graft. The model has never been tested rigorously in a large species, though the rationale for why the procedures should work applies across species including humans. Confirming the results in a large species would have profound impact on research for treating multiple immune mediated diseases, in addition to providing a way for treating some transplant recipients. This is a propitious time to confirm the applicability to larger species. If successful, only the lack of imagination limits the potential impact." @default.
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• W2108134138 date "2010-08-19" @default.
• W2108134138 modified "2023-10-18" @default.
• W2108134138 title "Prevention of renal allograft rejection without immune suppression: a model to revisit" @default.
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• W2108134138 doi "https://doi.org/10.1111/j.1399-0012.2010.01314.x" @default.
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