FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108134955> ?p ?o ?g. }

• W2108134955 endingPage "3427" @default.
• W2108134955 startingPage "3422" @default.
• W2108134955 abstract "The unprecedented genetic diversity found at vertebrate MHC (major histocompatibility complex) loci influences susceptibility to most infectious and autoimmune diseases. The evolutionary explanation for how these polymorphisms are maintained has been controversial. One leading explanation, antagonistic coevolution (also known as the Red Queen), postulates a never-ending molecular arms race where pathogens evolve to evade immune recognition by common MHC alleles, which in turn provides a selective advantage to hosts carrying rare MHC alleles. This cyclical process leads to negative frequency-dependent selection and promotes MHC diversity if two conditions are met: ( i ) pathogen adaptation must produce trade-offs that result in pathogen fitness being higher in familiar (i.e., host MHC genotype adapted to) vs. unfamiliar host MHC genotypes; and ( ii ) this adaptation must produce correlated patterns of virulence (i.e., disease severity). Here we test these fundamental assumptions using an experimental evolutionary approach (serial passage). We demonstrate rapid adaptation and virulence evolution of a mouse-specific retrovirus to its mammalian host across multiple MHC genotypes. Critically, this adaptive response results in trade-offs (i.e., antagonistic pleiotropy) between host MHC genotypes; both viral fitness and virulence is substantially higher in familiar versus unfamiliar MHC genotypes. These data are unique in experimentally confirming the requisite conditions of the antagonistic coevolution model of MHC evolution and providing quantification of fitness effects for pathogen and host. These data help explain the unprecedented diversity of MHC genes, including how disease-causing alleles are maintained." @default.
• W2108134955 created "2016-06-24" @default.
• W2108134955 creator A5035220521 @default.
• W2108134955 creator A5047587735 @default.
• W2108134955 creator A5050776969 @default.
• W2108134955 creator A5062661686 @default.
• W2108134955 creator A5074857968 @default.
• W2108134955 date "2012-02-07" @default.
• W2108134955 modified "2023-10-15" @default.
• W2108134955 title "Experimental viral evolution to specific host <i>MHC</i> genotypes reveals fitness and virulence trade-offs in alternative <i>MHC</i> types" @default.
• W2108134955 cites W1929921649 @default.
• W2108134955 cites W1965776393 @default.
• W2108134955 cites W1987772873 @default.
• W2108134955 cites W2000982327 @default.
• W2108134955 cites W2002587842 @default.
• W2108134955 cites W2005634497 @default.
• W2108134955 cites W2009444355 @default.
• W2108134955 cites W2038599188 @default.
• W2108134955 cites W2065471056 @default.
• W2108134955 cites W2067108995 @default.
• W2108134955 cites W2074850103 @default.
• W2108134955 cites W2075928272 @default.
• W2108134955 cites W2086013059 @default.
• W2108134955 cites W2100301899 @default.
• W2108134955 cites W2100534595 @default.
• W2108134955 cites W2116067373 @default.
• W2108134955 cites W2118494668 @default.
• W2108134955 cites W2122003337 @default.
• W2108134955 cites W2130783116 @default.
• W2108134955 cites W2145976400 @default.
• W2108134955 cites W2151541423 @default.
• W2108134955 cites W2157460269 @default.
• W2108134955 cites W2161064205 @default.
• W2108134955 cites W2168673397 @default.
• W2108134955 cites W2169029547 @default.
• W2108134955 cites W2169847792 @default.
• W2108134955 cites W2176191850 @default.
• W2108134955 cites W2180414983 @default.
• W2108134955 cites W4229803116 @default.
• W2108134955 cites W4239551491 @default.
• W2108134955 cites W4299498251 @default.
• W2108134955 cites W4367169726 @default.
• W2108134955 doi "https://doi.org/10.1073/pnas.1112633109" @default.
• W2108134955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3295311" @default.
• W2108134955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22323587" @default.
• W2108134955 hasPublicationYear "2012" @default.
• W2108134955 type Work @default.
• W2108134955 sameAs 2108134955 @default.
• W2108134955 citedByCount "82" @default.
• W2108134955 countsByYear W21081349552012 @default.
• W2108134955 countsByYear W21081349552013 @default.
• W2108134955 countsByYear W21081349552014 @default.
• W2108134955 countsByYear W21081349552015 @default.
• W2108134955 countsByYear W21081349552016 @default.
• W2108134955 countsByYear W21081349552017 @default.
• W2108134955 countsByYear W21081349552018 @default.
• W2108134955 countsByYear W21081349552019 @default.
• W2108134955 countsByYear W21081349552020 @default.
• W2108134955 countsByYear W21081349552021 @default.
• W2108134955 countsByYear W21081349552022 @default.
• W2108134955 countsByYear W21081349552023 @default.
• W2108134955 crossrefType "journal-article" @default.
• W2108134955 hasAuthorship W2108134955A5035220521 @default.
• W2108134955 hasAuthorship W2108134955A5047587735 @default.
• W2108134955 hasAuthorship W2108134955A5050776969 @default.
• W2108134955 hasAuthorship W2108134955A5062661686 @default.
• W2108134955 hasAuthorship W2108134955A5074857968 @default.
• W2108134955 hasBestOaLocation W21081349551 @default.
• W2108134955 hasConcept C104317684 @default.
• W2108134955 hasConcept C126831891 @default.
• W2108134955 hasConcept C135763542 @default.
• W2108134955 hasConcept C137848329 @default.
• W2108134955 hasConcept C139807058 @default.
• W2108134955 hasConcept C169760540 @default.
• W2108134955 hasConcept C170627219 @default.
• W2108134955 hasConcept C180754005 @default.
• W2108134955 hasConcept C207936829 @default.
• W2108134955 hasConcept C2776914050 @default.
• W2108134955 hasConcept C33009525 @default.
• W2108134955 hasConcept C54355233 @default.
• W2108134955 hasConcept C60987743 @default.
• W2108134955 hasConcept C78458016 @default.
• W2108134955 hasConcept C86803240 @default.
• W2108134955 hasConceptScore W2108134955C104317684 @default.
• W2108134955 hasConceptScore W2108134955C126831891 @default.
• W2108134955 hasConceptScore W2108134955C135763542 @default.
• W2108134955 hasConceptScore W2108134955C137848329 @default.
• W2108134955 hasConceptScore W2108134955C139807058 @default.
• W2108134955 hasConceptScore W2108134955C169760540 @default.
• W2108134955 hasConceptScore W2108134955C170627219 @default.
• W2108134955 hasConceptScore W2108134955C180754005 @default.
• W2108134955 hasConceptScore W2108134955C207936829 @default.
• W2108134955 hasConceptScore W2108134955C2776914050 @default.
• W2108134955 hasConceptScore W2108134955C33009525 @default.
• W2108134955 hasConceptScore W2108134955C54355233 @default.
• W2108134955 hasConceptScore W2108134955C60987743 @default.
• W2108134955 hasConceptScore W2108134955C78458016 @default.
• W2108134955 hasConceptScore W2108134955C86803240 @default.

• next