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• W2108137706 abstract "Abstract Cellular prion protein (PrP) is prominently expressed in brain, in differentiated neurons but also in neural stem/precursor cells (NPCs). The misfolding of PrP is a central event in prion diseases, yet the physiological function of PrP is insufficiently understood. Although PrP has been reported to associate with the neural cell adhesion molecule (NCAM), the consequences of concerted PrP-NCAM action in NPC physiology are unknown. Here, we generated NPCs from the subventricular zone (SVZ) of postnatal day 5 wild-type and PrP null (−/−) mice and observed that PrP is essential for proper NPC proliferation and neuronal differentiation. Moreover, we found that PrP is required for the NPC response to NCAM-induced neuronal differentiation. In the absence of PrP, NCAM not only fails to promote neuronal differentiation but also induces an accumulation of doublecortin-positive neuronal progenitors at the proliferation stage. In agreement, we noted an increase in cycling neuronal progenitors in the SVZ of PrP−/− mice compared with PrP+/+ mice, as evidenced by double labeling for the proliferation marker Ki67 and doublecortin as well as by 5-bromo-2′-deoxyuridine incorporation experiments. Additionally, fewer newly born neurons were detected in the rostral migratory stream of PrP−/− mice. Analysis of the migration of SVZ cells in microexplant cultures from wild-type and PrP−/− mice revealed no differences between genotypes or a role for NCAM in this process. Our data demonstrate that PrP plays a critical role in neuronal differentiation of NPCs and suggest that this function is, at least in part, NCAM-dependent. Stem Cells 2014;32:1674–1687" @default.
• W2108137706 created "2016-06-24" @default.
• W2108137706 creator A5049912899 @default.
• W2108137706 creator A5071050099 @default.
• W2108137706 creator A5073394134 @default.
• W2108137706 creator A5078914374 @default.
• W2108137706 date "2014-05-23" @default.
• W2108137706 modified "2023-10-14" @default.
• W2108137706 title "Functional Cross-Talk Between the Cellular Prion Protein and the Neural Cell Adhesion Molecule is Critical for Neuronal Differentiation of Neural Stem/Precursor Cells" @default.
• W2108137706 cites W1479941048 @default.
• W2108137706 cites W1489920031 @default.
• W2108137706 cites W1525425401 @default.
• W2108137706 cites W1548959511 @default.
• W2108137706 cites W1569299704 @default.
• W2108137706 cites W1859730138 @default.
• W2108137706 cites W1965257207 @default.
• W2108137706 cites W1968723804 @default.
• W2108137706 cites W1969584185 @default.
• W2108137706 cites W1969758868 @default.
• W2108137706 cites W1969875668 @default.
• W2108137706 cites W1970921752 @default.
• W2108137706 cites W1971078992 @default.
• W2108137706 cites W1971752958 @default.
• W2108137706 cites W1975683282 @default.
• W2108137706 cites W1979653508 @default.
• W2108137706 cites W1983725263 @default.
• W2108137706 cites W1984831424 @default.
• W2108137706 cites W1985630952 @default.
• W2108137706 cites W1986166279 @default.
• W2108137706 cites W1987169792 @default.
• W2108137706 cites W1992172768 @default.
• W2108137706 cites W1992380356 @default.
• W2108137706 cites W1993222068 @default.
• W2108137706 cites W1994276113 @default.
• W2108137706 cites W1996331932 @default.
• W2108137706 cites W1996879968 @default.
• W2108137706 cites W1996995775 @default.
• W2108137706 cites W2008004502 @default.
• W2108137706 cites W2010473698 @default.
• W2108137706 cites W2017903142 @default.
• W2108137706 cites W2022131253 @default.
• W2108137706 cites W2026299157 @default.
• W2108137706 cites W2031240108 @default.
• W2108137706 cites W2032338659 @default.
• W2108137706 cites W2032860676 @default.
• W2108137706 cites W2033822105 @default.
• W2108137706 cites W2042978244 @default.
• W2108137706 cites W2050331820 @default.
• W2108137706 cites W2051989931 @default.
• W2108137706 cites W2054712002 @default.
• W2108137706 cites W2063735329 @default.
• W2108137706 cites W2065471991 @default.
• W2108137706 cites W2067856703 @default.
• W2108137706 cites W2069252618 @default.
• W2108137706 cites W2071782304 @default.
• W2108137706 cites W2072052853 @default.
• W2108137706 cites W2073472657 @default.
• W2108137706 cites W2075705981 @default.
• W2108137706 cites W2076020654 @default.
• W2108137706 cites W2077439063 @default.
• W2108137706 cites W2082289133 @default.
• W2108137706 cites W2082401415 @default.
• W2108137706 cites W2083072084 @default.
• W2108137706 cites W2084652820 @default.
• W2108137706 cites W2086782135 @default.
• W2108137706 cites W2091887710 @default.
• W2108137706 cites W2092079020 @default.
• W2108137706 cites W2092413007 @default.
• W2108137706 cites W2100921685 @default.
• W2108137706 cites W2105619265 @default.
• W2108137706 cites W2109103923 @default.
• W2108137706 cites W2110029042 @default.
• W2108137706 cites W2116256646 @default.
• W2108137706 cites W2120021517 @default.
• W2108137706 cites W2121147886 @default.
• W2108137706 cites W2127981299 @default.
• W2108137706 cites W2132345933 @default.
• W2108137706 cites W2135046848 @default.
• W2108137706 cites W2138554096 @default.
• W2108137706 cites W2138712855 @default.
• W2108137706 cites W2139286715 @default.
• W2108137706 cites W2140197173 @default.
• W2108137706 cites W2147465611 @default.
• W2108137706 cites W2147987476 @default.
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• W2108137706 doi "https://doi.org/10.1002/stem.1663" @default.
• W2108137706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24497115" @default.
• W2108137706 hasPublicationYear "2014" @default.
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