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• W2108144639 abstract "The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway." @default.
• W2108144639 created "2016-06-24" @default.
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• W2108144639 date "2001-06-05" @default.
• W2108144639 modified "2023-09-29" @default.
• W2108144639 title "A crystallographic map of the transition from B-DNA to A-DNA" @default.
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• W2108144639 doi "https://doi.org/10.1073/pnas.121176898" @default.
• W2108144639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/34657" @default.
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