Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108146306> ?p ?o ?g. }
- W2108146306 endingPage "9902" @default.
- W2108146306 startingPage "9898" @default.
- W2108146306 abstract "Glycosyltransferases (GTs) comprise a prominent family of enzymes that play critical roles in a variety of cellular processes, including cell signaling, cell development, and host-pathogen interactions. Glycosyl transfer can proceed with either inversion or retention of the anomeric configuration with respect to the reaction substrates and products. The elucidation of the catalytic mechanism of retaining GTs remains a major challenge. A native ternary complex of a GT in a productive mode for catalysis is reported, that of the retaining glucosyl-3-phosphoglycerate synthase GpgS from M. tuberculosis in the presence of the sugar donor UDP-Glc, the acceptor substrate phosphoglycerate, and the divalent cation cofactor. Through a combination of structural, chemical, enzymatic, molecular dynamics, and quantum-mechanics/molecular-mechanics (QM/MM) calculations, the catalytic mechanism was unraveled, thereby providing a strong experimental support for a front-side substrate-assisted SN i-type reaction." @default.
- W2108146306 created "2016-06-24" @default.
- W2108146306 creator A5009913961 @default.
- W2108146306 creator A5019073507 @default.
- W2108146306 creator A5021052769 @default.
- W2108146306 creator A5027106244 @default.
- W2108146306 creator A5027767603 @default.
- W2108146306 creator A5032933384 @default.
- W2108146306 creator A5037428417 @default.
- W2108146306 creator A5044046340 @default.
- W2108146306 creator A5046981723 @default.
- W2108146306 creator A5050190363 @default.
- W2108146306 creator A5054874364 @default.
- W2108146306 creator A5059131751 @default.
- W2108146306 creator A5070328472 @default.
- W2108146306 creator A5075336747 @default.
- W2108146306 creator A5079082841 @default.
- W2108146306 creator A5085600610 @default.
- W2108146306 date "2015-07-01" @default.
- W2108146306 modified "2023-10-07" @default.
- W2108146306 title "A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase" @default.
- W2108146306 cites W1862479421 @default.
- W2108146306 cites W1965466877 @default.
- W2108146306 cites W1980553599 @default.
- W2108146306 cites W1980671235 @default.
- W2108146306 cites W1994448362 @default.
- W2108146306 cites W2008819551 @default.
- W2108146306 cites W2038663238 @default.
- W2108146306 cites W2059720930 @default.
- W2108146306 cites W2067787044 @default.
- W2108146306 cites W2080780084 @default.
- W2108146306 cites W2083919147 @default.
- W2108146306 cites W2087271883 @default.
- W2108146306 cites W2112921913 @default.
- W2108146306 cites W2119412579 @default.
- W2108146306 cites W2121580575 @default.
- W2108146306 cites W2131458606 @default.
- W2108146306 cites W2133465431 @default.
- W2108146306 cites W2139958335 @default.
- W2108146306 cites W2142775793 @default.
- W2108146306 cites W2162331387 @default.
- W2108146306 cites W2319280160 @default.
- W2108146306 cites W3004582312 @default.
- W2108146306 cites W4233369779 @default.
- W2108146306 cites W4235712585 @default.
- W2108146306 cites W4244580768 @default.
- W2108146306 doi "https://doi.org/10.1002/anie.201504617" @default.
- W2108146306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26136334" @default.
- W2108146306 hasPublicationYear "2015" @default.
- W2108146306 type Work @default.
- W2108146306 sameAs 2108146306 @default.
- W2108146306 citedByCount "34" @default.
- W2108146306 countsByYear W21081463062016 @default.
- W2108146306 countsByYear W21081463062017 @default.
- W2108146306 countsByYear W21081463062019 @default.
- W2108146306 countsByYear W21081463062020 @default.
- W2108146306 countsByYear W21081463062021 @default.
- W2108146306 countsByYear W21081463062022 @default.
- W2108146306 countsByYear W21081463062023 @default.
- W2108146306 crossrefType "journal-article" @default.
- W2108146306 hasAuthorship W2108146306A5009913961 @default.
- W2108146306 hasAuthorship W2108146306A5019073507 @default.
- W2108146306 hasAuthorship W2108146306A5021052769 @default.
- W2108146306 hasAuthorship W2108146306A5027106244 @default.
- W2108146306 hasAuthorship W2108146306A5027767603 @default.
- W2108146306 hasAuthorship W2108146306A5032933384 @default.
- W2108146306 hasAuthorship W2108146306A5037428417 @default.
- W2108146306 hasAuthorship W2108146306A5044046340 @default.
- W2108146306 hasAuthorship W2108146306A5046981723 @default.
- W2108146306 hasAuthorship W2108146306A5050190363 @default.
- W2108146306 hasAuthorship W2108146306A5054874364 @default.
- W2108146306 hasAuthorship W2108146306A5059131751 @default.
- W2108146306 hasAuthorship W2108146306A5070328472 @default.
- W2108146306 hasAuthorship W2108146306A5075336747 @default.
- W2108146306 hasAuthorship W2108146306A5079082841 @default.
- W2108146306 hasAuthorship W2108146306A5085600610 @default.
- W2108146306 hasBestOaLocation W21081463062 @default.
- W2108146306 hasConcept C161019410 @default.
- W2108146306 hasConcept C161790260 @default.
- W2108146306 hasConcept C178790620 @default.
- W2108146306 hasConcept C181199279 @default.
- W2108146306 hasConcept C185592680 @default.
- W2108146306 hasConcept C18903297 @default.
- W2108146306 hasConcept C197957613 @default.
- W2108146306 hasConcept C20803032 @default.
- W2108146306 hasConcept C2776376580 @default.
- W2108146306 hasConcept C2777289219 @default.
- W2108146306 hasConcept C2780906977 @default.
- W2108146306 hasConcept C55493867 @default.
- W2108146306 hasConcept C71240020 @default.
- W2108146306 hasConcept C74884574 @default.
- W2108146306 hasConcept C7947691 @default.
- W2108146306 hasConcept C86756495 @default.
- W2108146306 hasConcept C86803240 @default.
- W2108146306 hasConceptScore W2108146306C161019410 @default.
- W2108146306 hasConceptScore W2108146306C161790260 @default.
- W2108146306 hasConceptScore W2108146306C178790620 @default.
- W2108146306 hasConceptScore W2108146306C181199279 @default.