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• W2108149042 startingPage "3792" @default.
• W2108149042 abstract "The relationship between the primary sequence of tubulins and their properties in cells was studied by gene transfection experiments. Previously, we studied a chimeric beta-tubulin formed from chicken beta-tubulin-2 sequences in the amino-terminal portion and the highly divergent Saccharomyces cerevisiae TUB2 sequences in the carboxy-terminal 25% of the molecule. In the cytoplasm of cultured animal cells, this protein incorporates into all microtubule structures and assembles with the same efficiency as endogenous tubulin. We show that the protein products of chimeric genes with an increasing proportion of yeast sequence, extending 5' of the carboxy-terminal 25%, are abnormal in two ways. First, they assemble with a significantly lower efficiency than the original chimeric protein or the endogenous tubulins. Second, they are less stable in the cytoplasm. The results suggest that the position of the yeast sequences is crucial in determining the properties of the molecule. Results of analyses of 1 deletion mutation and 10 linker insertions in the original chimeric tubulin suggest that those changes made outside the carboxyl terminus completely disrupt assembly activity, while those made in the carboxyl terminus do not." @default.
• W2108149042 created "2016-06-24" @default.
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• W2108149042 creator A5049485062 @default.
• W2108149042 creator A5087661235 @default.
• W2108149042 date "1987-10-01" @default.
• W2108149042 modified "2023-09-25" @default.
• W2108149042 title "Domains of beta-tubulin essential for conserved functions in vivo" @default.
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• W2108149042 doi "https://doi.org/10.1128/mcb.7.10.3792-3798.1987" @default.
• W2108149042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/368036" @default.
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